Showing 1-12 of 12 results for "f0767"
J D Isaacs et al.
Clinical and experimental immunology, 110(2), 158-166 (1997-11-21)
We have investigated the biological and therapeutic properties of a humanized anti-CD4 MoAb, hIgG1-CD4, in patients with refractory psoriasis and rheumatoid arthritis (RA). hIgG1-CD4 is a modulating, non-depleting MoAb, which induced a first-dose reaction in most patients treated. It provided...
Tissue factor expression in ovarian cancer: implications for immunotherapy with hI-con1, a factor VII-IgGFc chimeric protein targeting tissue factor
Cocco E, et al.
Clinical & Experimental Metastasis, 28 (2011)
hI-con1, a factor VII-IgGFc chimeric protein targeting tissue factor for immunotherapy of uterine serous papillary carcinoma
Cocco E, et al.
British Journal of Cancer, 103 (2010)
Emiliano Cocco et al.
BMC cancer, 11, 263-263 (2011-06-23)
Cervical cancer continues to be an important worldwide health problem for women. Up to 35% of patients who are diagnosed with and appropriately treated for cervical cancer will recur and treatment results are poor for recurrent disease. Given these sobering...
Elion Hoxha et al.
Kidney international, 82(7), 797-804 (2012-06-08)
The M-type phospholipase A2 receptor (PLA2R) is the major target antigen in idiopathic membranous nephropathy with detectable autoantibodies in the serum of up to 70% of patients. In retrospective studies, the PLA2R-autoantibody titer in the serum was sometimes negative indicating...
Andreas Recke et al.
Journal of immunology (Baltimore, Md. : 1950), 193(4), 1600-1608 (2014-07-16)
Subepidermal autoimmune blistering dermatoses (AIBD) are prototypic autoantibody-mediated diseases. In epidermolysis bullosa acquisita (EBA), an autoimmune disease with severe and chronic skin blistering, autoantibodies are directed against type VII collagen. IgG is the predominant autoantibody isotype of EBA, the pathogenicity...
Elion Hoxha et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 26(8), 2526-2532 (2011-06-03)
The recent finding that phospholipase-A(2)-receptor antibodies (PLA(2)R-AB) may play a role in the development of primary membranous glomerulonephritis (MGN) offers the opportunity to measure a marker to help diagnose, classify and eventually monitor the course of patients with MGN. We...
E Cocco et al.
British journal of cancer, 103(6), 812-819 (2010-08-12)
Uterine serous papillary adenocarcinoma (USPC) is a highly aggressive variant of endometrial cancer. Human immuno-conjugate molecule (hI-con1) is an antibody-like molecule targeted against tissue factor (TF), composed of two human Factor VII (fVII) as the targeting domain, fused to human...
Bastien Joubert et al.
JAMA neurology, 73(9), 1115-1124 (2016-07-19)
Autoantibodies against contactin-associated protein-like 2 (CASPR2) are observed in several neurological syndromes, including neuromyotonia (NMT), Morvan syndrome (MoS), and limbic encephalitis. To characterize the clinical and biological presentations of patients with anti-CASPR2 antibodies in the cerebrospinal fluid (CSF). We conducted...
Jocelyn-S Fraser et al.
World journal of gastroenterology, 12(48), 7805-7809 (2007-01-05)
To assess the level of undiagnosed coeliac disease (CD) in relatives of patients affected by the condition. We collected blood from 914 relatives of probands. We screened these individuals by ELISA for IgA and IgG tTG antibodies, confirming any positive...
Muren Huhe et al.
Biochemical and biophysical research communications, 513(4), 1083-1091 (2019-04-24)
Cluster of differentiation 147 (CD147), a transmembrane protein of the immunoglobulin superfamily, is a potential target of treatment against human non-small cell lung cancer (NSCLC). Although there have been exciting advances in epidermal growth factor receptor (EGFR)-targeted therapy for NSCLC...
Emiliano Cocco et al.
Clinical & experimental metastasis, 28(7), 689-700 (2011-07-05)
We evaluated the expression of tissue factor (TF) in ovarian cancer (EOC) and the potential of hI-con1, an antibody-like molecule targeting TF, as a novel form of therapy against chemotherapy-resistant ovarian disease. We studied the expression of TF in 88...

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