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F0888

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Rawad Hodeify et al.
Journal of cell science, 128(16), 3143-3154 (2015-06-28)
The key proteins mediating store-operated Ca(2+) entry (SOCE) are the endoplasmic reticulum (ER) Ca(2+) sensor STIM1 and the plasma membrane Ca(2+)-selective channel Orai1. Here, we quantitatively dissect Orai1 trafficking dynamics and show that Orai1 recycles rapidly at the plasma membrane...
J L Donato et al.
British journal of pharmacology, 119(7), 1447-1453 (1996-12-01)
1. Proteoglycans provide negatively charged sites on the surface of platelets, leukocytes and endothelial cells. Since chondroitin 4-sulphate is the main proteoglycan present on the platelet surface, the role of this molecule in mediating the activation of human platelets by...
Wan-Jung Lu et al.
Platelets, 25(8), 595-602 (2014-01-18)
Hinokitiol (4-isopropyl-tropolone) is a bioactive compound with various pharmacological activities that is found in the wood of cupressaceous plants. Platelet activation plays an important role in thrombogenesis. In our previous study, hinokitiol specifically inhibited collagen-induced platelet aggregation ex vivo and...
Filip Bednar et al.
Journal of immunology (Baltimore, Md. : 1950), 192(11), 5305-5313 (2014-04-30)
The cross-regulation of G protein-coupled receptors (GPCRs) plays an important role in the immune response. Studies from several laboratories have suggested that a hierarchy of sensitivities to cross-desensitization exists for the chemoattractant GPCRs. We carried out experiments to study the...
Rachana D Sharma et al.
Journal of pineal research, 59(2), 240-254 (2015-06-24)
Oxidative stress-induced methemoglobinemia remained an untouched area in venom pharmacology till date. This study for the first time explored the potential of animal venoms to oxidize hemoglobin to methemoglobin. In in vitro whole-blood assay, methemoglobin forming ability of venoms varied...
Huamei Forsman et al.
Biochimica et biophysica acta, 1853(1), 192-200 (2014-12-03)
Pathogenic Staphylococcus aureus strains produce N-formylmethionyl containing peptides, of which the tetrapeptide fMIFL is a potent activator of the neutrophil formyl peptide receptor 1 (FPR1) and the PSMα2 peptide is a potent activator of the closely related FPR2. Variants derived...
Ningyong Xu et al.
American journal of physiology. Cell physiology, 308(4), C277-C288 (2014-11-28)
Orai1 interacts with transient receptor potential protein of the canonical subfamily (TRPC4) and contributes to calcium selectivity of the endothelial cell store-operated calcium entry current (ISOC). Orai1 silencing increases sodium permeability and decreases membrane-associated calcium, although it is not known...
Dan Stratton et al.
Biochemical and biophysical research communications, 460(3), 511-517 (2015-03-24)
MVs are released in response to several stress agents, in an attempt to prevent continued cellular damage. After an initial stimulus of prostate cancer cells with sublytic C5b-9 and activation of MV release through PKC, cells take at least 20...
Yung-Chih Kuo et al.
Journal of pharmaceutical sciences, 103(8), 2484-2497 (2014-07-22)
Liposomes with Cereport (RMP-7) and transferrin (Tf) (RMP-7/Tf/liposomes) were employed to target the blood-brain barrier (BBB) and to inhibit the degeneration of neurons insulted with fibrillar β-amyloid peptide 1-42 (Aβ1-42). Neuron growth factor (NGF)-encapsulated RMP-7/Tf/liposomes (RMP-7/Tf/NGF-liposomes) were used to permeate...
Giorgio Fois et al.
Cell calcium, 58(6), 628-637 (2015-11-13)
Ambroxol (Ax) is a frequently prescribed drug used to facilitate mucociliary clearance, but its mode of action is yet poorly understood. Here we show by X-ray spectroscopy that Ax accumulates in lamellar bodies (LBs), the surfactant storing, secretory lysosomes of...
Victoria L Hodgkinson et al.
American journal of physiology. Cell physiology, 309(10), C660-C668 (2015-08-14)
Menkes disease is a fatal neurodegenerative disorder arising from a systemic copper deficiency caused by loss-of-function mutations in a ubiquitously expressed copper transporter, ATP7A. Although this disorder reveals an essential role for copper in the developing human nervous system, the...
Heejin Jun et al.
Developmental cell, 54(1), 106-116 (2020-06-14)
Maintaining energy homeostasis upon environmental challenges, such as cold or excess calorie intake, is essential to the fitness and survival of mammals. Drug discovery efforts targeting β-adrenergic signaling have not been fruitful after decades of intensive research. We recently identified...
Steven H Young et al.
Biochemical and biophysical research communications, 467(1), 1-6 (2015-10-04)
The extracellular Ca(2+)-sensing receptor (CaSR) is an allosteric protein that responds to changes in the extracellular concentration of Ca(2+) ([Ca(2+)]e) and aromatic amino acids with the production of different patterns of oscillations in intracellular Ca(2+) concentration ([Ca(2+)]i). An increase in...
Xiulin Zhang et al.
The Journal of physiology, 592(19), 4297-4312 (2014-08-17)
Effects of nitro-oleic acid (OA-NO2) on TRP channels were examined in guinea-pig dissociated dorsal root ganglia (DRG) neurons using calcium imaging and patch clamp techniques. OA-NO2 increased intracellular Ca(2+) in 60-80% DRG neurons. 1-Oleoyl-2acetyl-sn-glycerol (OAG), a TRPC agonist, elicited responses...
B T Kinsella et al.
The Journal of pharmacology and experimental therapeutics, 281(2), 957-964 (1997-05-01)
To establish whether the thromboxane A2 (TXA2) receptor (TP) functionally couples to the Gq family of heterotrimeric G proteins in vivo, we have coexpressed the cDNAs coding for the human platelet/placental TP alpha isoform (TP alpha) and the alpha subunits...
Cynthia M de Bont et al.
Biochimica et biophysica acta. Molecular cell research, 1865(11 Pt A), 1621-1629 (2018-10-18)
Neutrophils can release their chromatin to form neutrophil extracellular traps (NETs), a process known as NETosis. Although NET formation can be induced by various stimuli, recent evidence suggests that these stimuli do so via different mechanisms. Here, we have analysed...
Andreja Brodarac et al.
Stem cell research & therapy, 6, 83-83 (2015-04-23)
Induced pluripotent stem cell-derived cardiomyocytes (iPS-CMs) may be suitable for myocardial repair. While their functional and structural properties have been extensively investigated, their response to ischemia-like conditions has not yet been clearly defined. iPS-CMs were differentiated and enriched from murine...
Silvia Nistri et al.
Molecules (Basel, Switzerland), 20(6), 9524-9535 (2015-05-29)
We demonstrated that in coronary endothelial cells (RCEs) from normotensive Wistar Kyoto rats (WKY), the hormone relaxin (RLX) increases NO production and reduces calcium transients by a NO-related mechanism. Since an impairment of the NO pathway has been described in...
Wei-Chun Wei et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(34), 10738-10743 (2015-08-12)
G protein-coupled receptors (GPCRs) are cell surface receptors that detect a wide range of extracellular messengers and convey this information to the inside of cells. Extracellular calcium-sensing receptor (CaSR) and ovarian cancer gene receptor 1 (OGR1) are two GPCRs that...
Gabriela Trevisan et al.
Naunyn-Schmiedeberg's archives of pharmacology, 387(7), 679-689 (2014-04-12)
The transient receptor potential ankyrin 1 (TRPA1) has been identified as a relevant target for the development of novel analgesics. Gallic acid (GA) is a polyphenolic compound commonly found in green tea and various berries and possesses a wide range...
Dan Zhao et al.
Biochemical and biophysical research communications, 519(2), 366-371 (2019-09-15)
Zinc finger homeobox 3 (ZFHX3) is a transcription factor that regulates multiple cellular processes including cell proliferation, differentiation and neoplastic development. It is also involved in the function of steroid hormones estrogen and progesterone and the peptide hormone prolactin in...
Soong-Yu Kuo et al.
Life sciences, 132, 55-60 (2015-04-29)
Vibrio vulnificusis an opportunistic pathogen that causes primary septicemia and wound infection with high mortality rate. This pathogen produces an RTX toxin (RtxA1) which can cause host cell rounding, cell death and interference with internalization by host phagocytes. However, the...
Kevin Monaghan et al.
PloS one, 10(6), e0128359-e0128359 (2015-06-06)
Retinal endothelial cell dysfunction is believed to play a key role in the etiology and pathogenesis of diabetic retinopathy. Numerous studies have shown that TRPV4 channels are critically involved in maintaining normal endothelial cell function. In the current paper, we...
Marten Szibor et al.
The Journal of biological chemistry, 295(14), 4383-4397 (2020-02-26)
Mitochondrial oxidative phosphorylation (OXPHOS) and cellular workload are tightly balanced by the key cellular regulator, calcium (Ca2+). Current models assume that cytosolic Ca2+ regulates workload and that mitochondrial Ca2+ uptake precedes activation of matrix dehydrogenases, thereby matching OXPHOS substrate supply...
Leiting Pan et al.
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 6(18), 1900865-1900865 (2019-09-29)
The dynamic response of the cell to osmotic changes is critical to its physiology and is widely exploited for cell manipulation. Here, using three-dimensional stochastic optical reconstruction microscopy (3D-STORM), a super-resolution technique, the hypotonic stress-induced ultrastructural changes of the cytoskeleton...
Assessment of intracellular Ca2+, cAMP and 1,2-diacylglycerol in cryopreserved buffalo (Bubalus bubalis) spermatozoa on supplementation of taurine and trehalose in the extender.
Singh VK
Reproduction in domestic animals = Zuchthygiene, 47, 584-584 (2012)
Maria M Docanto et al.
Breast cancer research and treatment, 147(1), 193-201 (2014-07-25)
Aromatase converts androgens into estrogens and its expression within adipose stromal cells (ASCs) is believed to be the major driver of estrogen-dependent cancers in older women. Ghrelin is a gut-hormone that is involved in the regulation of appetite and known...
Oanh H Do et al.
Diabetologia, 57(7), 1400-1409 (2014-04-08)
We used the db/db mouse to determine the nature of the secretory defect in intact islets. Glucose tolerance was compared in db/db and wild-type (WT) mice. Isolated islets were used: to measure insulin secretion and calcium in a two-photon assay...
T Vaisitti et al.
Leukemia, 29(2), 356-368 (2014-07-06)
The ecto-enzyme CD38 is gaining momentum as a novel therapeutic target for patients with hematological malignancies, with several anti-CD38 monoclonal antibodies in clinical trials with promising results. In chronic lymphocytic leukemia (CLL) CD38 is a marker of unfavorable prognosis and...
Na Li et al.
Scientific reports, 5, 13225-13225 (2015-08-19)
Caffeine modifies vascular/cardiac contractility. Embryonic exposure to caffeine altered cardiac functions in offspring. This study determined chronic influence of prenatal caffeine on vessel functions in offspring. Pregnant Sprague-Dawley rats (5-month-old) were exposed to high dose of caffeine, their offspring (5-month-old)...
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