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J L Donato et al.
British journal of pharmacology, 119(7), 1447-1453 (1996-12-01)
1. Proteoglycans provide negatively charged sites on the surface of platelets, leukocytes and endothelial cells. Since chondroitin 4-sulphate is the main proteoglycan present on the platelet surface, the role of this molecule in mediating the activation of human platelets by
Giorgio Fois et al.
Cell calcium, 58(6), 628-637 (2015-11-13)
Ambroxol (Ax) is a frequently prescribed drug used to facilitate mucociliary clearance, but its mode of action is yet poorly understood. Here we show by X-ray spectroscopy that Ax accumulates in lamellar bodies (LBs), the surfactant storing, secretory lysosomes of
Filip Bednar et al.
Journal of immunology (Baltimore, Md. : 1950), 192(11), 5305-5313 (2014-04-30)
The cross-regulation of G protein-coupled receptors (GPCRs) plays an important role in the immune response. Studies from several laboratories have suggested that a hierarchy of sensitivities to cross-desensitization exists for the chemoattractant GPCRs. We carried out experiments to study the
Ningyong Xu et al.
American journal of physiology. Cell physiology, 308(4), C277-C288 (2014-11-28)
Orai1 interacts with transient receptor potential protein of the canonical subfamily (TRPC4) and contributes to calcium selectivity of the endothelial cell store-operated calcium entry current (ISOC). Orai1 silencing increases sodium permeability and decreases membrane-associated calcium, although it is not known
Huamei Forsman et al.
Biochimica et biophysica acta, 1853(1), 192-200 (2014-12-03)
Pathogenic Staphylococcus aureus strains produce N-formylmethionyl containing peptides, of which the tetrapeptide fMIFL is a potent activator of the neutrophil formyl peptide receptor 1 (FPR1) and the PSMα2 peptide is a potent activator of the closely related FPR2. Variants derived
Wan-Jung Lu et al.
Platelets, 25(8), 595-602 (2014-01-18)
Hinokitiol (4-isopropyl-tropolone) is a bioactive compound with various pharmacological activities that is found in the wood of cupressaceous plants. Platelet activation plays an important role in thrombogenesis. In our previous study, hinokitiol specifically inhibited collagen-induced platelet aggregation ex vivo and
Rawad Hodeify et al.
Journal of cell science, 128(16), 3143-3154 (2015-06-28)
The key proteins mediating store-operated Ca(2+) entry (SOCE) are the endoplasmic reticulum (ER) Ca(2+) sensor STIM1 and the plasma membrane Ca(2+)-selective channel Orai1. Here, we quantitatively dissect Orai1 trafficking dynamics and show that Orai1 recycles rapidly at the plasma membrane
Victoria L Hodgkinson et al.
American journal of physiology. Cell physiology, 309(10), C660-C668 (2015-08-14)
Menkes disease is a fatal neurodegenerative disorder arising from a systemic copper deficiency caused by loss-of-function mutations in a ubiquitously expressed copper transporter, ATP7A. Although this disorder reveals an essential role for copper in the developing human nervous system, the
Heejin Jun et al.
Developmental cell, 54(1), 106-116 (2020-06-14)
Maintaining energy homeostasis upon environmental challenges, such as cold or excess calorie intake, is essential to the fitness and survival of mammals. Drug discovery efforts targeting β-adrenergic signaling have not been fruitful after decades of intensive research. We recently identified
Wei-Chun Wei et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(34), 10738-10743 (2015-08-12)
G protein-coupled receptors (GPCRs) are cell surface receptors that detect a wide range of extracellular messengers and convey this information to the inside of cells. Extracellular calcium-sensing receptor (CaSR) and ovarian cancer gene receptor 1 (OGR1) are two GPCRs that
Andreja Brodarac et al.
Stem cell research & therapy, 6, 83-83 (2015-04-23)
Induced pluripotent stem cell-derived cardiomyocytes (iPS-CMs) may be suitable for myocardial repair. While their functional and structural properties have been extensively investigated, their response to ischemia-like conditions has not yet been clearly defined. iPS-CMs were differentiated and enriched from murine
Dan Zhao et al.
Biochemical and biophysical research communications, 519(2), 366-371 (2019-09-15)
Zinc finger homeobox 3 (ZFHX3) is a transcription factor that regulates multiple cellular processes including cell proliferation, differentiation and neoplastic development. It is also involved in the function of steroid hormones estrogen and progesterone and the peptide hormone prolactin in
Gabriela Trevisan et al.
Naunyn-Schmiedeberg's archives of pharmacology, 387(7), 679-689 (2014-04-12)
The transient receptor potential ankyrin 1 (TRPA1) has been identified as a relevant target for the development of novel analgesics. Gallic acid (GA) is a polyphenolic compound commonly found in green tea and various berries and possesses a wide range
Cynthia M de Bont et al.
Biochimica et biophysica acta. Molecular cell research, 1865(11 Pt A), 1621-1629 (2018-10-18)
Neutrophils can release their chromatin to form neutrophil extracellular traps (NETs), a process known as NETosis. Although NET formation can be induced by various stimuli, recent evidence suggests that these stimuli do so via different mechanisms. Here, we have analysed
Silvia Nistri et al.
Molecules (Basel, Switzerland), 20(6), 9524-9535 (2015-05-29)
We demonstrated that in coronary endothelial cells (RCEs) from normotensive Wistar Kyoto rats (WKY), the hormone relaxin (RLX) increases NO production and reduces calcium transients by a NO-related mechanism. Since an impairment of the NO pathway has been described in
Rachana D Sharma et al.
Journal of pineal research, 59(2), 240-254 (2015-06-24)
Oxidative stress-induced methemoglobinemia remained an untouched area in venom pharmacology till date. This study for the first time explored the potential of animal venoms to oxidize hemoglobin to methemoglobin. In in vitro whole-blood assay, methemoglobin forming ability of venoms varied
Xiulin Zhang et al.
The Journal of physiology, 592(19), 4297-4312 (2014-08-17)
Effects of nitro-oleic acid (OA-NO2) on TRP channels were examined in guinea-pig dissociated dorsal root ganglia (DRG) neurons using calcium imaging and patch clamp techniques. OA-NO2 increased intracellular Ca(2+) in 60-80% DRG neurons. 1-Oleoyl-2acetyl-sn-glycerol (OAG), a TRPC agonist, elicited responses
B T Kinsella et al.
The Journal of pharmacology and experimental therapeutics, 281(2), 957-964 (1997-05-01)
To establish whether the thromboxane A2 (TXA2) receptor (TP) functionally couples to the Gq family of heterotrimeric G proteins in vivo, we have coexpressed the cDNAs coding for the human platelet/placental TP alpha isoform (TP alpha) and the alpha subunits
Steven H Young et al.
Biochemical and biophysical research communications, 467(1), 1-6 (2015-10-04)
The extracellular Ca(2+)-sensing receptor (CaSR) is an allosteric protein that responds to changes in the extracellular concentration of Ca(2+) ([Ca(2+)]e) and aromatic amino acids with the production of different patterns of oscillations in intracellular Ca(2+) concentration ([Ca(2+)]i). An increase in
Dan Stratton et al.
Biochemical and biophysical research communications, 460(3), 511-517 (2015-03-24)
MVs are released in response to several stress agents, in an attempt to prevent continued cellular damage. After an initial stimulus of prostate cancer cells with sublytic C5b-9 and activation of MV release through PKC, cells take at least 20
Yung-Chih Kuo et al.
Journal of pharmaceutical sciences, 103(8), 2484-2497 (2014-07-22)
Liposomes with Cereport (RMP-7) and transferrin (Tf) (RMP-7/Tf/liposomes) were employed to target the blood-brain barrier (BBB) and to inhibit the degeneration of neurons insulted with fibrillar β-amyloid peptide 1-42 (Aβ1-42). Neuron growth factor (NGF)-encapsulated RMP-7/Tf/liposomes (RMP-7/Tf/NGF-liposomes) were used to permeate
Marilyn J Cipolla et al.
Journal of applied physiology (Bethesda, Md. : 1985), 117(1), 53-59 (2014-05-03)
Brain parenchymal arterioles (PAs) are high-resistance vessels that branch off pial arteries and perfuse the brain parenchyma. PAs are the target of cerebral small vessel disease and have been shown to have greater pressure-induced tone at lower pressures than pial
Kirsi Penttinen et al.
PloS one, 10(5), e0125366-e0125366 (2015-05-09)
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a highly malignant inherited arrhythmogenic disorder. Type 1 CPVT (CPVT1) is caused by cardiac ryanodine receptor (RyR2) gene mutations resulting in abnormal calcium release from sarcoplasmic reticulum. Dantrolene, an inhibitor of sarcoplasmic Ca(2+) release
Effects of Taurine or Trehalose supplementation on functional competence of cryopreserved Karan Fries semen.
Chhillar S
Animal Reproduction, 135, 1-1 (2012)
Dmitry G Semenov et al.
Neurochemical research, 40(11), 2200-2210 (2015-09-01)
The study assessed involvement of Ca(2+) signaling mediated by the metabotropic glutamate receptors mGluR1/5 in brain tolerance induced by hypoxic preconditioning. Acute slices of rat piriform cortex were tested 1 day after exposure of adult rats to mild hypobaric hypoxia
Ju-Ye Ro et al.
SpringerPlus, 4, 17-17 (2015-01-30)
The effects of onion peel extract (OPE) in collagen (5 μg/mL)-stimulated washed rat platelet aggregation were investigated. OPE inhibited platelet aggregation via inhibition of aggregation-inducing molecules, intracellular Ca(2+) and thromboxane A2 (TXA2) by blocking cyclooxygenase-1 (COX-1) and TXA2 synthase (TXAS) activities
Daniel R Gonzalez et al.
American journal of physiology. Heart and circulatory physiology, 307(5), H710-H721 (2014-07-13)
Duchenne muscular dystrophy may affect cardiac muscle, producing a dystrophic cardiomyopathy in humans and the mdx mouse. We tested the hypothesis that oxidative stress participates in disrupting calcium handling and contractility in the mdx mouse with established cardiomyopathy. We found
Oanh H Do et al.
Diabetologia, 57(7), 1400-1409 (2014-04-08)
We used the db/db mouse to determine the nature of the secretory defect in intact islets. Glucose tolerance was compared in db/db and wild-type (WT) mice. Isolated islets were used: to measure insulin secretion and calcium in a two-photon assay
Rosa Gómez-Villafuertes et al.
Cell transplantation, 24(8), 1493-1509 (2014-09-10)
Spinal cord injury (SCI) is a major cause of paralysis with no current therapies. Following SCI, large amounts of ATP and other nucleotides are released by the traumatized tissue leading to the activation of purinergic receptors that, in coordination with
T Vaisitti et al.
Leukemia, 29(2), 356-368 (2014-07-06)
The ecto-enzyme CD38 is gaining momentum as a novel therapeutic target for patients with hematological malignancies, with several anti-CD38 monoclonal antibodies in clinical trials with promising results. In chronic lymphocytic leukemia (CLL) CD38 is a marker of unfavorable prognosis and
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