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Alexei Poliakov et al.
The Journal of cell biology, 183(5), 933-947 (2008-12-03)
In this study, we investigated whether the ability of Eph receptor signaling to mediate cell repulsion is antagonized by fibroblast growth factor receptor (FGFR) activation that can promote cell invasion. We find that activation of FGFR1 in EphB2-expressing cells prevents...
Dubeiqi Hong et al.
Cell death and differentiation, 26(8), 1453-1466 (2018-10-27)
Transmembrane protein 268 (TMEM268) encodes a novel human protein of previously unknown function. This study analyzed the biological activities and molecular mechanisms of TMEM268 in vivo and in vitro. We found that TMEM268 deletion decreases cell viability, proliferation, and cell...
Nasim Eskandari et al.
Cryobiology, 85, 63-72 (2018-10-08)
Cryopreservation of endothelium is one of the major challenges in the cryopreservation of complex tissues. Human umbilical vein endothelial cells (HUVECs) in suspension are available commercially and recently their post-thaw cell membrane integrity was significantly improved by cryopreservation in 5%...
Chloé Delépine et al.
Human molecular genetics, 25(1), 146-157 (2015-11-26)
Rett syndrome (RTT) is a rare X-linked neurodevelopmental disorder, characterized by normal post-natal development followed by a sudden deceleration in brain growth with progressive loss of acquired motor and language skills, stereotypic hand movements and severe cognitive impairment. Mutations in...
Autoantibodies, 221-251 (2007)
Ana Mendanha Falcão et al.
Cell reports, 27(4), 1090-1102 (2019-04-25)
Citrullination, the deimination of peptidylarginine residues into peptidylcitrulline, has been implicated in the etiology of several diseases. In multiple sclerosis, citrullination is thought to be a major driver of pathology through hypercitrullination and destabilization of myelin. As such, inhibition of...
Daniel Roth et al.
Journal of cell science, 132(4) (2018-09-29)
EB proteins track the ends of growing microtubules and regulate microtubule dynamics both directly and by acting as the hub of the tip-tracking network. Mammalian cells express cell type-specific combinations of three EB proteins with different cellular roles. Here, we...
Magali Berthouze et al.
The EMBO journal, 28(12), 1684-1696 (2009-05-09)
Agonist-induced ubiquitination of the beta(2) adrenergic receptor (beta(2)AR) functions as an important post-translational modification to sort internalized receptors to the lysosomes for degradation. We now show that this ubiquitination is reversed by two deubiquitinating enzymes, ubiquitin-specific proteases (USPs) 20 and...
Jason Fan et al.
Molecular metabolism, 34, 97-111 (2020-03-18)
Diabetes is characterized by pancreatic β-cell dedifferentiation. Dedifferentiating β cells inappropriately metabolize lipids over carbohydrates and exhibit impaired mitochondrial oxidative phosphorylation. However, the mechanism linking the β-cell's response to an adverse metabolic environment with impaired mitochondrial function remains unclear. Here...
Nicolas Malaquin et al.
EMBO reports, 21(10), e50718-e50718 (2020-08-14)
Senescent cells display senescence-associated (SA) phenotypic programs such as stable proliferation arrest (SAPA) and a secretory phenotype (SASP). Senescence-inducing persistent DNA double-strand breaks (pDSBs) cause an immediate DNA damage response (DDR) and SAPA, but the SASP requires days to develop....
Sweta Ramachandran et al.
PloS one, 12(8), e0183624-e0183624 (2017-09-01)
Biomarkers of heart failure in adults have been extensively studied. However, biomarkers to monitor the progression of heart failure in children with univentricular physiology are less well understood. We proposed that as mediators of diverse pathophysiology, miRNAs contained within circulating...
Mengying Wang et al.
PloS one, 15(4), e0232321-e0232321 (2020-05-01)
Decorin is a member of small leucine-rich proteoglycan family, which is involved in multiple biological functions mainly as a structural and signaling molecule, and disturbances in its own metabolism plays a crucial role in the pathogenesis of osteoarthropathy. In this...
Shiny Shengzhen Guo et al.
Development (Cambridge, England), 147(22) (2020-10-15)
The notochord drives longitudinal growth of the body axis by convergent extension, a highly conserved developmental process that depends on non-canonical Wnt/planar cell polarity (PCP) signaling. However, the role of cell-matrix interactions mediated by integrins in the development of the...
Olga Shakhova et al.
Methods in molecular biology (Clifton, N.J.) (2015-12-15)
During development, melanocyte progenitors originate from the neural crest, a transient embryonic structure in vertebrates that gives rise to a variety of cell types including neurons and glia of the peripheral nervous system, smooth muscle cells of the cardiovascular system...
Karina M Lugo-Cintrón et al.
Lab on a chip, 20(9), 1586-1600 (2020-04-17)
Lymphatic vessels (LVs) have been suggested as a preferential conduit for metastatic progression in breast cancer, where a correlation between the occurrence of lymph node metastasis and an increased extracellular matrix (ECM) density has been reported. However, the effect of...
Alyssa McCulloch et al.
Journal of neurointerventional surgery, 13(8), 727-731 (2020-10-28)
The goal of this work was to endothelialize silicone aneurysm tubes for use as in vitro models for evaluating endothelial cell interactions with neurovascular devices. The first objective was to establish consistent and confluent endothelial cell linings and to evaluate...
Leda Lacaria et al.
Biochemical and biophysical research communications, 525(4), 836-840 (2020-03-14)
Living cells interact with the extracellular matrix (ECM) transducing biochemical signals into mechanical cues and vice versa. Thanks to this mechano-transduction process, cells modify their internal organization and upregulate their physiological functions differently. In this complex mechanism integrins play a...
Henriette Christie Ertsås et al.
Integrative biology : quantitative biosciences from nano to macro, 9(2), 123-134 (2017-01-20)
Microenvironmental cues comprising surface-mediated and soluble factors control cellular signaling mechanisms underlying normal cellular responses that define homeostatic and diseased cell states. In order to measure cell signaling in single adherent cells, we developed a novel microsphere-based flow cytometry approach....
Vanessa Nunes et al.
Molecular biology of the cell, 31(16), 1675-1690 (2020-04-30)
During the initial stages of cell division, the cytoskeleton is extensively reorganized so that a bipolar mitotic spindle can be correctly assembled. This process occurs through the action of molecular motors, cytoskeletal networks, and the nucleus. How the combined activity...
Bingxi Yan et al.
The journal of physical chemistry. B, 123(40), 8580-8589 (2019-09-19)
Broad applications of electropolymerized conducting polymers (CPs) often prefer thinner soft electrodes to comply with downscaling of the fabrication resolution. However, high conductivity of existing CP films vanishes as thickness decreases to the nanoscale (i.e., below 100 nm), with an...
Timothée Vignaud et al.
Nature materials, 20(3), 410-420 (2020-10-21)
Contractile actomyosin networks are responsible for the production of intracellular forces. There is increasing evidence that bundles of actin filaments form interconnected and interconvertible structures with the rest of the network. In this study, we explored the mechanical impact of...
Joana Catarina Macedo et al.
Nature communications, 9(1), 2834-2834 (2018-07-22)
Aneuploidy, an abnormal chromosome number, has been linked to aging and age-associated diseases, but the underlying molecular mechanisms remain unknown. Here we show, through direct live-cell imaging of young, middle-aged, and old-aged primary human dermal fibroblasts, that aneuploidy increases with...
Ita Costello et al.
BMC developmental biology, 9, 54-54 (2009-10-24)
Smad4 mutant embryos arrest shortly after implantation and display a characteristic shortened proximodistal axis, a significantly reduced epiblast, as well as a thickened visceral endoderm layer. Conditional rescue experiments demonstrate that bypassing the primary requirement for Smad4 in the extra-embryonic...
Alessandro Siani et al.
Scientific reports, 5, 9278-9278 (2015-03-24)
In vitro models of fibrotic phenomena are often based on the fibroblast-myofibroblast transition as the contraction-triggering cellular event. There are, however, multiple sources of concern regarding the appropriateness of such models; a first and widely investigated issue is the often...
Lionel Chièze et al.
Journal of molecular recognition : JMR, 32(3), e2767-e2767 (2018-11-08)
A method was developed to characterize the adhesion properties of single cells by using protein-functionalized atomic force microscopy (AFM) probes. The quantification by force spectroscopy of the mean detachment force between cells and a gelatin-functionalized colloidal tip reveals differences in...
Vincent Hyenne et al.
Developmental cell, 48(4), 554-572 (2019-02-13)
Tumor extracellular vesicles (EVs) mediate the communication between tumor and stromal cells mostly to the benefit of tumor progression. Notably, tumor EVs travel in the bloodstream, reach distant organs, and locally modify the microenvironment. However, visualizing these events in vivo still...
Anh La et al.
Tissue engineering. Part A, 24(15-16), 1242-1250 (2018-02-17)
Conferring antithrombogenicity to tissue-engineered vascular grafts remains a major challenge, especially for urgent bypass grafting that excludes approaches based on expanding autologous endothelial cells (ECs) that requires weeks of cell culture. Adipose-derived stem cells (ASCs) are available from most patients...
Naiyan Wen et al.
International journal of oncology, 55(4), 879-895 (2019-09-06)
Bromodomain and extraterminal domain proteins, especially bromodomain‑containing protein 4 (Brd4), have recently emerged as therapeutic targets for several cancers, although the role and mechanism of Brd4 in glioblastoma multiforme (GBM) are unclear. In this study, we aimed to explore the...
Weiming Ouyang et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(8), 4078-4087 (2020-02-12)
Anthrax lethal toxin (LT) is a protease virulence factor produced by Bacillus anthracis that is required for its pathogenicity. LT treatment causes a rapid degradation of c-Jun protein that follows inactivation of the MEK1/2-Erk1/2 signaling pathway. Here we identify COP1...
Enhanced fibronectin adsorption on carbon nanotube/poly (carbonate) urethane: independent role of surface nano-roughness and associated surface energy
Khang D, et al.
Biomaterials, 28(32), 4756-4768 (2007)
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