Showing 1-11 of 11 results for "F1304"
Patricia A Madureira et al.
The Journal of biological chemistry, 281(35), 25167-25176 (2006-07-01)
In this study, we have identified the Forkhead transcription factor FoxM1 as a physiological regulator of estrogen receptor alpha (ERalpha) expression in breast carcinoma cells. Our survey of a panel of 16 different breast cell lines showed a good correlation...
Miguel Quiros et al.
Molecular biology of the cell, 24(16), 2528-2543 (2013-06-28)
Zona occludens 2 (ZO-2) has a dual localization. In confluent epithelia, ZO-2 is present at tight junctions (TJs), whereas in sparse proliferating cells it is also found at the nucleus. Previously we demonstrated that in sparse cultures, newly synthesized ZO-2...
Astrid Eijkelenboom et al.
Cell reports, 5(6), 1664-1678 (2013-12-24)
Forkhead box O (FOXO) transcription factors regulate diverse cellular processes, affecting tumorigenesis, metabolism, stem cell maintenance, and lifespan. We show that FOXO3 transcription regulation mainly proceeds through the most active subset of enhancers. In addition to the general distinction between...
Xingnan Zheng et al.
Genes & development, 28(13), 1429-1444 (2014-07-06)
The three EglN prolyl hydroxylases (EglN1, EglN2, and EglN3) regulate the stability of the HIF transcription factor. We recently showed that loss of EglN2, however, also leads to down-regulation of Cyclin D1 and decreased cell proliferation in a HIF-independent manner....
Oliver Dick et al.
The Journal of biological chemistry, 285(25), 19354-19361 (2010-04-21)
Synaptic activity and the generation of nuclear calcium signals promote neuronal survival through a transcription-dependent process that is not fully understood. Here we show that one mechanism of activity-induced acquired neuroprotection involves the Forkhead transcription factor, FoxO3a, which is known...
Rosaline C-Y Hui et al.
Molecular and cellular biology, 28(19), 5886-5898 (2008-07-23)
The phosphoinositide-3 kinase (PI3K)/Akt signal pathway plays a key role in the tumorigenesis of many cancers and in the subsequent development of drug resistance. Using the K562 chronic myelogenous leukemia (CML) cell line and the doxorubicin-resistant derivative lines KD30 and...
F Wang et al.
Oncogene, 31(12), 1546-1557 (2011-08-16)
Sirtuin deacetylases and FOXO (Forkhead box, class O) transcription factors have important roles in many biological pathways, including cancer development. SIRT1 and SIRT2 deacetylate FOXO factors to regulate FOXO function. Because acetylation and ubiquitination both modify the ɛ-amino group of...
Naoki Suzuki et al.
The Journal of clinical investigation, 117(9), 2468-2476 (2007-09-06)
Forkhead box O (Foxo) transcription factors induce muscle atrophy by upregulating the muscle-specific E3 ubiquitin ligases MuRF-1 and atrogin-1/MAFbx, but other than Akt, the upstream regulators of Foxos during muscle atrophy are largely unknown. To examine the involvement of the...
Ummuhani Ozel Turkcu et al.
Gene, 536(1), 129-134 (2013-12-18)
Vitiligo is an acquired epidermal pigment loss of the skin. Oxidative stress is one of the major theories in the pathophysiology of vitiligo. FOXO3A is the forkhead members of the class O (FOXO) transcription factors, and plays an important role...
M J Anderson et al.
Genomics, 47(2), 187-199 (1998-02-28)
Alveolar rhabdomyosarcomas are associated with unique chromosomal translocations t(2;13) and t(1;13), which arise from fusion of the genes for the paired box proteins PAX3 and PAX7, respectively, to the FKHR (forkhead in rhabdomyosarcoma) gene on chromosome 13q14. Here we report...
Juewon Kim et al.
The Journal of investigative dermatology, 134(5), 1378-1388 (2013-11-29)
Forkhead box-O (FoxO) family transcriptional factors control the expression of many genes involved in a variety of cellular processes. Melanogenesis is an oxidizing process; therefore, many antioxidants are used to inhibit melanin production. However, their mechanism of action is poorly...

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