In adult mammalian brains, neurogenesis persists in the subventricular zone of the lateral ventricles (SVZ) and the dentate gyrus (DG) of the hippocampus. Although evidence suggest that adult neurogenesis in these two regions is subjected to differential regulation, the underlying...
FXR1 regulates transcription and is required for growth of human cancer cells with TP53/FXR2 homozygous deletion
Human molecular genetics, 6(8), 1315-1322 (1997-08-01)
Lack of expression of the fragile X mental retardation protein (FMRP) results in mental retardation and macroorchidism, seen as the major pathological symptoms in fragile X patients. FMRP is a cytoplasmic RNA-binding protein which cosediments with the 60S ribosomal subunit....
Human molecular genetics, 8(5), 863-869 (1999-04-10)
Fragile X syndrome is caused by the absence of the fragile X mental retardation protein (FMRP). FMRP and its structural homologues FXR1P and FXR2P form a family of RNA-binding proteins (FXR proteins). The three proteins associate with polyribosomes as cytoplasmic...
Fragile X Mental Retardation Syndrome is the most common form of hereditary mental retardation, and is caused by defects in the FMR1 gene. FMR1 is an RNA-binding protein and the syndrome results from lack of expression of FMR1 or expression...
Fragile X granules are a family of axonal ribonucleoprotein particles with circuit-dependent protein composition and m RNA cargos
Chyung E, et al.
The Journal of Comparative Neurology, 526(1), 96-108 (2018)
Knockout mouse model for Fxr2: a model for mental retardation
Bontekoe CJM, et al.
Human Molecular Genetics, 11(5), 487-498 (2002)
Widespread RNA editing dysregulation in brains from autistic individuals
Tran SS, et al.
Nature Neuroscience, 22(1), 25-25 (2019)
Interplay between FMRP and lncRNA TUG1 regulates axonal development through mediating SnoN-Ccd1 pathway.
The rat androgen-binding protein/sex hormone-binding globulin (ABP/SHBG) gene is regulated by promoters P1 and PA. P1 regulates the mRNA encoding secreted ABP/SHBG, whereas PA regulates an alternate mRNA which encodes a modified protein that is targeted to the nucleus. Promoter...
The Journal of comparative neurology, 526(1), 96-108 (2017-09-09)
Local axonal protein synthesis plays a crucial role in the formation and function of neuronal circuits. Understanding the role of this mechanism in specific circuits requires identifying the protein composition and mRNA cargos of the ribonucleoprotein particles (RNPs) that form...
Interplay between FMRP and lncRNA TUG1 regulates axonal development through mediating SnoN-Ccd1 pathway
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