Showing 1-16 of 16 results for "F2772"
M Kita-Furuyama et al.
Clinical and experimental immunology, 131(2), 234-240 (2003-02-04)
Dendritic cells (DCs) are the most potent antigen-presenting cells and a prerequisite for the initiation of primary immune response. This study was performed to investigate the contribution of DCs to the initiation of Graves' hyperthyroidism, an organ-specific autoimmune disease in...
Raheem Peerani et al.
Methods in molecular biology (Clifton, N.J.), 482, 21-33 (2008-12-18)
Local micro-environmental cues consisting of soluble cytokines, extra-cellular matrix (ECM), and cell-cell contacts are determining factors in stem cell fate. These extrinsic cues form a 'niche' that governs a stem cell's decision to either self-renew or differentiate into one or...
Mohammadhossein Khorraminejad-Shirazi et al.
Stem cell research & therapy, 11(1), 45-45 (2020-02-06)
Mesenchymal stromal cell (MSC) stemness capacity diminishes over prolonged in vitro culture, which negatively affects their application in regenerative medicine. To slow down the senescence of MSCs, here, we have evaluated the in vitro effects of 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), an...
J S Plested et al.
Infection and immunity, 69(5), 3203-3213 (2001-04-09)
A recently described flow cytometric opsonophagocytic assay (OPA) was adapted to quantify the functional activity of serum antibodies specifically directed against serogroup B inner core lipopolysaccharide (LPS) of Neisseria meningitidis. The percentage of human peripheral polymorphonuclear leukocytes and monocytes (PMNms)...
Sylwia Ammoun et al.
The Journal of biological chemistry, 281(2), 834-842 (2005-11-12)
We have investigated the signaling of OX(1) receptors to cell death using Chinese hamster ovary cells as a model system. OX(1) receptor stimulation with orexin-A caused a delayed cell death independently of cytosolic Ca(2+) elevation. The classical mitogen-activated protein kinase...
Ana Cecilia Machado Diaz et al.
Arthritis, 2012, 943156-943156 (2012-08-14)
Rheumatoid arthritis (RA) is an autoimmune and inflammatory disease in which many cytokines have been implicated. In particular, IL-15 is a cytokine involved in the inflammatory processes and bone loss. The aim of this study was to investigate the existence...
Placental transfer of IgG subclasses in a Japanese population.
Hashira S, et al.
Pediatrics International, 42(4) (2000)
Pernille B Jørgensen et al.
PloS one, 7(9), e46120-e46120 (2012-10-11)
Multiple sclerosis (MS) is associated with Epstein-Barr virus (EBV) infection, but impaired immune suppression may be part of the disease pathogenesis. CD8(+) T cells that are restricted by HLA-E exert an important immunoregulatory mechanism. To explore how EBV might interfere...
Hong Chen et al.
Reproduction, fertility, and development, 31(4), 774-786 (2018-12-12)
Spermatozoa are known to be stored in the epididymis of the Chinese soft-shelled turtle Pelodiscus sinensis for long periods after spermiation from the testes, but the molecular mechanisms underlying this storage are largely unknown. In this study, epididymal spermatozoa were...
Morten Harboe et al.
Journal of immunology (Baltimore, Md. : 1950), 189(5), 2606-2613 (2012-08-02)
Properdin is well known as an enhancer of the alternative complement amplification loop when C3 is activated, whereas its role as a recognition molecule of exogenous pathogen-associated molecular patterns and initiator of complement activation is less understood. We therefore studied...
Mami Nakahara et al.
Endocrinology, 151(8), 4047-4054 (2010-06-18)
Graves-like hyperthyroidism is induced in BALB/c mice by immunization with adenovirus expressing the human TSH receptor (TSHR) A-subunit (amino acids 1-289). However, because of nonidentity between the human and mouse TSHR ( approximately 87% amino acid homology), we compared the...
Soghra Bahmanpour et al.
Biotechnic & histochemistry : official publication of the Biological Stain Commission, 95(3), 210-218 (2019-10-17)
Although embryonic stem (ES) cells can differentiate into germ cells, little is known about the influence of culture media on this process. We investigated the effect of two culture media on the capacity of ES cells to differentiate into germ...
Structure and function of immunoglobulins.
Schroeder Jr H W and Cavacini L
The Journal of Allergy and Clinical Immunology, 125(2), S41-S52 (2010)
Mami Nakahara et al.
Endocrinology, 153(4), 2034-2042 (2012-02-16)
We have recently shown that wild type mice are highly tolerant, whereas thyrotropin receptor (TSHR) knockout (KO) mice are susceptible to immunization with the mouse TSHR, the autoantigen in Graves' disease. However, because TSHR KO mice lack the endogenous TSHR...
Thomas Hills et al.
PloS one, 11(11), e0166383-e0166383 (2016-11-20)
The need for CD4+ T cell responses to arise de novo following vaccination can limit the speed of B cell responses. Populations of pre-existing vaccine-induced or anti-viral CD4+ T cells recognising distinct antigens could be exploited to overcome this limitation....

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