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Delma Veron et al.
PloS one, 7(7), e40589-e40589 (2012-07-19)
Podocyte or endothelial cell VEGF-A knockout causes thrombotic microangiopathy in adult mice. To study the mechanism involved in acute and local injury caused by low podocyte VEGF-A we developed an inducible, podocyte-specific VEGF-A knockdown mouse, and we generated an immortalized...
Lei Jiang et al.
Kidney international, 84(2), 285-296 (2013-03-22)
Mitochondria dysfunction has been reported in various kidney diseases but how it leads to kidney fibrosis and how this is regulated is unknown. Here we found that mitochondrial uncoupling protein 2 (UCP2) was induced in kidney tubular epithelial cells after...
Lin Sun et al.
The Journal of biological chemistry, 291(11), 5688-5707 (2016-01-23)
Diabetic nephropathy (DN) is characterized by perturbations in metabolic/cellular signaling pathways with generation of reactive oxygen species (ROS). The ROS are regarded as a common denominator of various pathways, and they inflict injury on renal glomerular cells. Recent studies indicate...
Eleni Panousopoulou et al.
Journal of cell science, 129(9), 1915-1927 (2016-03-19)
Epiboly is a morphogenetic process that is employed in the surface ectoderm of anamniotes during gastrulation to cover the entire embryo. We propose here that mammals also utilise this process to expand the epidermis and enclose the body cavity and...
Leyla Zilic et al.
Journal of anatomy, 227(3), 302-314 (2015-07-23)
Current nerve tissue engineering applications are adopting xenogeneic nerve tissue as potential nerve grafts to help aid nerve regeneration. However, there is little literature that describes the exact location, anatomy and physiology of these nerves to highlight their potential as...
Bo Hu et al.
Development (Cambridge, England), 145(17) (2018-08-08)
During embryogenesis, the germ layers, including the endoderm, undergo convergence and extension movements to narrow and elongate the body plan. In zebrafish, the dorsal migration of endodermal cells during gastrulation is controlled by chemokine signaling, but little is known about...
Hui-Hua Chang et al.
PloS one, 12(9), e0184455-e0184455 (2017-09-09)
Epidemiologic data has linked obesity to a higher risk of pancreatic cancer, but the underlying mechanisms are poorly understood. To allow for detailed mechanistic studies in a relevant model mimicking diet-induced obesity and pancreatic cancer, a high-fat, high-calorie diet (HFCD)...
Maxwell B Johnson et al.
Scientific reports, 7(1), 3876-3876 (2017-06-22)
Wound healing is significantly delayed in irradiated skin. To better understand global changes in protein expression after radiation, we utilized a reverse phase protein array (RPPA) to identify significant changes in paired samples of normal and irradiated human skin. Of...
Laila Dafik et al.
Chemistry & biology, 18(1), 58-66 (2011-02-01)
We report the synthesis and preliminary characterization of "clickable" inhibitors of human transglutaminase 2 (TG2). These inhibitors possess the 3-halo-4,5-dihydroisoxazole warhead along with bioorthogonal groups such as azide or alkyne moieties that enable subsequent covalent modification with fluorophores. Their mechanism...
Anne-Laure Duchemin et al.
eLife, 8 (2019-09-17)
Mechanical forces are well known for modulating heart valve developmental programs. Yet, it is still unclear how genetic programs and mechanosensation interact during heart valve development. Here, we assessed the mechanosensitive pathways involved during zebrafish outflow tract (OFT) valve development...
Sabrina Kellouche et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 31(2), 129-139 (2010-04-02)
Ovarian cancer progression is frequently associated with the development of malignant ascites. Multicellular aggregates of carcinoma cells (spheroids) found within ascites are thought to be able to promote peritoneal carcinomatosis. We have previously demonstrated the involvement of the vitronectin/alphav integrin...
Robert Moore et al.
Molecular and cellular biology, 34(3), 560-572 (2013-11-28)
We analyzed the mechanism of developmental failure in implanted β1 integrin-null blastocysts and found that primitive endoderm cells are present but segregate away from, instead of forming an epithelial layer covering, the inner cell mass. This cell segregation phenotype was...
Ting-Hein Lee et al.
Journal of biomedical science, 26(1), 37-37 (2019-05-18)
The blood-spinal cord barrier (BSCB) is composed of a monolayer of endothelium linked with tight junctions and extracellular matrix (ECM)-rich basement membranes and is surrounded by astrocyte foot processes. Endothelial permeability is regulated by interaction between endothelial cells and ECM...
Go Nagamatsu et al.
Science advances, 5(6), eaav9960-eaav9960 (2019-06-30)
The most immature oocytes remain dormant in primordial follicles in the ovary, ensuring the longevity of female reproductive life. Despite its biological and clinical importance, knowledge of mechanisms regulating the dormant state remains limited. Here, we show that mechanical stress...
Alexandre Dubrac et al.
Nature communications, 9(1), 3463-3463 (2018-08-29)
Pericytes are mural cells that surround capillaries and control angiogenesis and capillary barrier function. During sprouting angiogenesis, endothelial cell-derived platelet-derived growth factor-B (PDGF-B) regulates pericyte proliferation and migration via the platelet-derived growth factor receptor-β (PDGFRβ). PDGF-B overexpression has been associated...
Leyla Zilic et al.
Biotechnology and bioengineering, 113(9), 2041-2053 (2016-03-02)
Peripheral nerve injuries affect a large proportion of the global population, often causing significant morbidity and loss of function. Current treatment strategies include the use of implantable nerve guide conduits (NGC's) to direct regenerating axons between the proximal and distal...
Gaurav K Keshri et al.
PloS one, 11(11), e0166705-e0166705 (2016-11-20)
Chronic non-healing cutaneous wounds are often vulnerable in one or more repair phases that prevent normal healing and pose challenges to the use of conventional wound care modalities. In immunosuppressed subject, the sequential stages of healing get hampered, which may...
Elaine Ngan et al.
Nature communications, 8, 15059-15059 (2017-04-25)
We have previously shown that lipoma preferred partner (LPP) mediates TGFβ-induced breast cancer cell migration and invasion. Herein, we demonstrate that diminished LPP expression reduces circulating tumour cell numbers, impairs cancer cell extravasation and diminishes lung metastasis. LPP localizes to...
Julien Gonzalez et al.
Biochemical and biophysical research communications, 438(2), 257-263 (2013-07-23)
Most end-stage renal disease kidneys display accumulation of extracellular matrix (ECM) in the renal tubular compartment (tubular interstitial fibrosis - TIF) which is strongly correlated with the future loss of renal function. Although inflammation is a key event in the...
Dudley H McNitt et al.
The Journal of biological chemistry, 293(20), 7796-7810 (2018-04-05)
Keratinized epidermis constitutes a powerful barrier of the mucosa and skin, effectively preventing bacterial invasion, unless it is wounded and no longer protective. Wound healing involves deposition of distinct extracellular matrix (ECM) proteins enriched in cellular fibronectin (cFn) isoforms containing...
Norman J Hackl et al.
Scandinavian journal of gastroenterology, 45(3), 349-356 (2009-12-19)
Hepatic stellate cells only produce fibronectin isoforms in disease states. The isoform-defining domains can be detected in the blood circulation. This study examines whether circulating levels of fibronectin isoforms show a relationship with liver fibrosis on histology in patients with...
V Byles et al.
Oncogene, 31(43), 4619-4629 (2012-01-18)
The epithelial-to-mesenchymal transition (EMT) is a crucial program for the invasion and metastasis of epithelial tumors that involves loss of cell-cell adhesion and increased cell mobility; however, mechanisms underlying this transition are not fully elucidated. Here, we propose a novel...
Ruben Daum et al.
Cells, 9(3) (2020-03-27)
Appropriate mechanical properties and fast endothelialization of synthetic grafts are key to ensure long-term functionality of implants. We used a newly developed biostable polyurethane elastomer (TPCU) to engineer electrospun vascular scaffolds with promising mechanical properties (E-modulus: 4.8 ± 0.6 MPa...
Yashoda Chandorkar et al.
Nature communications, 10(1), 4027-4027 (2019-09-08)
Cells feel the forces exerted on them by the surrounding extracellular matrix (ECM) environment and respond to them. While many cell fate processes are dictated by these forces, which are highly synchronized in space and time, abnormal force transduction is...
Michelle M Collins et al.
eLife, 7 (2018-06-29)
Pitx2c, a homeodomain transcription factor, is classically known for its left-right patterning role. However, an early wave of pitx2 expression occurs at the onset of gastrulation in several species, indicating a possible earlier role that remains relatively unexplored. Here we...
Anders Sundqvist et al.
Nucleic acids research, 46(3), 1180-1195 (2017-12-01)
It is well established that transforming growth factor-β (TGFβ) switches its function from being a tumor suppressor to a tumor promoter during the course of tumorigenesis, which involves both cell-intrinsic and environment-mediated mechanisms. We are interested in breast cancer cells...
Hong Ding et al.
Journal of the American Society of Nephrology : JASN, 23(5), 801-813 (2012-02-04)
Sonic hedgehog (Shh) signaling is a developmental signal cascade that plays an essential role in regulating embryogenesis and tissue homeostasis. Here, we investigated the potential role of Shh signaling in renal interstitial fibrogenesis. Ureteral obstruction induced Shh, predominantly in the...
Ashley E Manis et al.
Journal of biological engineering, 1, 2-2 (2008-02-15)
Electrospinning is a non-mechanical processing strategy that can be used to process a variety of native and synthetic polymers into highly porous materials composed of nano-scale to micron-scale diameter fibers. By nature, electrospun materials exhibit an extensive surface area and...
Nandakumar K, et al.
Nanomedicine and Tissue Engineering: State of the Art and Recent Trends (2016)
Heiko Locher et al.
Developmental neurobiology, 75(11), 1219-1240 (2015-02-11)
Sensorineural hearing loss (SNHL) is one of the most common congenital disorders in humans, afflicting one in every thousand newborns. The majority is of heritable origin and can be divided in syndromic and nonsyndromic forms. Knowledge of the expression profile...
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