Showing 1-13 of 13 results for "F4055"
Ann L Wozniak et al.
The Journal of cell biology, 219(10) (2020-09-25)
Cells respond to inflammatory disease states by releasing exosomes containing highly specific protein and RNA cargos, but how inflammation alters cargo specificity and secretion of exosomes is unknown. We show that increases in exosome secretion induced by either viral infection...
Y Zhang et al.
The EMBO journal, 14(21), 5358-5366 (1995-11-01)
Fragile X Mental Retardation Syndrome is the most common form of hereditary mental retardation, and is caused by defects in the FMR1 gene. FMR1 is an RNA-binding protein and the syndrome results from lack of expression of FMR1 or expression...
Characterization of dFMR1, a Drosophila melanogaster homolog of the fragile X mental retardation protein
Wan L, et al.
Molecular and Cellular Biology, 20(22), 8536-8547 (2000)
Giuseppe LaFauci et al.
Genes, 7(12) (2016-12-13)
The final product of FMR1 gene transcription, Fragile X Mental Retardation Protein 1 (FMRP), is an RNA binding protein that acts as a repressor of translation. FMRP is expressed in several tissues and plays important roles in neurogenesis, synaptic plasticity...
Tanmoyita Nayak et al.
Frontiers in cellular neuroscience, 12, 231-231 (2018-08-23)
The NG2 proteoglycan is expressed by oligodendrocyte precursor cells (OPCs) and is abundantly expressed by tumors such as melanoma and glioblastoma. Functions of NG2 include an influence on proliferation, migration and neuromodulation. Similar to other type-1 membrane proteins, NG2 undergoes...
Differential Regulation of Syngap1 Translation by FMRP Modulates eEF2 Mediated Response on NMDAR Activity
Paul A, et al.
Frontiers in Molecular Neuroscience, 12 (2019)
Tatyana A Shelkovnikova et al.
Human molecular genetics, 23(19), 5211-5226 (2014-05-21)
Fused in sarcoma (FUS) is an RNA-binding protein involved in pathogenesis of several neurodegenerative diseases. Aggregation of mislocalized FUS into non-amyloid inclusions is believed to be pivotal in the development of cell dysfunction, but the mechanism of their formation is...
Michelle Ninochka D'Souza et al.
iScience, 9, 399-411 (2018-11-24)
FMRP is an RNA-binding protein that is known to localize in the cytoplasm and in the nucleus. Here, we have identified an interaction of FMRP with a specific set of C/D box snoRNAs in the nucleus. C/D box snoRNAs guide...
Gabi Schutzius et al.
Journal of neurodevelopmental disorders, 5(1), 8-8 (2013-04-04)
Hypermethylation of the fragile X mental retardation 1 gene FMR1 results in decreased expression of FMR1 protein FMRP, which is the underlying cause of Fragile X syndrome - an incurable neurological disorder characterized by mental retardation, anxiety, epileptic episodes and...
Evan P Booy et al.
Nucleic acids research, 46(21), 11575-11591 (2018-09-25)
BC200 is a long non-coding RNA primarily expressed in brain but aberrantly expressed in various cancers. To gain a further understanding of the function of BC200, we performed proteomic analyses of the BC200 ribonucleoprotein (RNP) by transfection of 3' DIG-labelled...
Christina Gross et al.
Cell reports, 11(5), 727-736 (2015-04-30)
The PI3K enhancer PIKE links PI3K catalytic subunits to group 1 metabotropic glutamate receptors (mGlu1/5) and activates PI3K signaling. The roles of PIKE in synaptic plasticity and the etiology of mental disorders are unknown. Here, we show that increased PIKE...
Dan O Wang et al.
Frontiers in molecular biosciences, 4, 93-93 (2018-01-10)
RNA transport and regulated local translation play critically important roles in spatially restricting gene expression in neurons. Heterogeneous population of RNA granules serve as motile units to translocate, store, translate, and degrade mRNAs in the dendrites contain
Chao Wu et al.
Cell death & disease, 10(4), 287-287 (2019-03-27)
During cortical development, neuronal migration is one of the most important steps for normal cortical formation and function, and defects in this process cause many brain diseases. However, the molecular mechanisms underlying this process remain largely unknown. In this study...

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