Showing 1-25 of 25 results for "f5512"
The Immunoglobulins: Structure and Function (1998)
Tomoyuki Mutoh et al.
Nature communications, 11(1), 1253-1253 (2020-03-11)
The presence of antiendothelial cell antibodies (AECAs) has been documented in Takayasu arteritis (TAK), a chronic granulomatous vasculitis. Here, we identify cell-surface autoantigens using an expression cloning system. A cDNA library of endothelial cells is retrovirally transfected into a rat...
Dawei Zhang et al.
Viruses, 5(4), 1131-1142 (2013-04-24)
Latent Membrane Protein 1 (LMP1) is a primary target for controlling tumorigenesis in Epstein-Barr virus related malignancies; in this study, we aimed to develop a specific antibody against the TES1 domain of the oncogenic LMP1. We screened a full human...
Mohammed Adil Butt et al.
Oncotarget, 8(15), 25080-25096 (2017-02-18)
Mucin glycoprotein 1 (MUC1) is a glycosylated transmembrane protein on epithelial cells. We investigate MUC1 as a therapeutic target in Barrett's epithelium (BE) and esophageal adenocarcinoma (EA) and provide proof of concept for a light based therapy targeting MUC1. MUC1...
Irina B Torres et al.
Clinical transplantation, 28(10), 1148-1154 (2014-08-12)
Transplant glomerulopathy (TG) is the characteristic lesion of chronic antibody-mediated rejection (AMR). However, in some patients presents with no circulating HLA antibodies or C4d positivity. Patients with TG accomplishing criteria for chronic AMR were compared to patients with isolated TG....
Human renal tubular epithelial cells as target cells for antibodies to proteinase 3 (c-ANCA).
A Schwarting et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 12(5), 916-923 (1997-05-01)
Specific IgG for cat allergens in patients with allergic conjunctivitis.
Miyama A, et al.
International Ophthalmology, 35(4), 575-586 (2015)
Miguel López-Lázaro et al.
Mutation research, 696(1), 41-47 (2009-12-23)
DNA topoisomerases (topos) are the target of several drugs commonly used in cancer chemotherapy; these drugs induce topo-DNA complexes with either topo I or topo II that eventually trigger cell death. The inhibition of these enzymes induces DNA alterations that...
Miguel López-Lázaro et al.
Mutagenesis, 26(4), 489-498 (2011-03-09)
Green tea and its major active constituent, (-)-epigallocatechin-3-gallate (EGCG), are in clinical trials for the prevention and treatment of several diseases such as cancer. DNA topoisomerase (topo) poisons are commonly prescribed anticancer drugs that kill cancer cells by inducing topo-DNA...
Christian Loch et al.
Journal of pharmaceutical sciences, 103(2), 517-526 (2013-12-07)
Intravitreal injections and drug-loaded implants are current approaches to treat diseases of the posterior eye. To investigate the release of active agents and their distribution in the vitreous body, a new test system was developed that enables a realistic simulation...
Maria Bottermann et al.
Cell host & microbe, 25(4), 617-629 (2019-03-31)
The complement system is vital for anti-microbial defense. In the classical pathway, pathogen-bound antibody recruits the C1 complex (C1qC1r2C1s2) that initiates a cleavage cascade involving C2, C3, C4, and C5 and triggering microbial clearance. We demonstrate a C4-dependent antiviral mechanism...
Antibody structure, instability, and formulation.
Wang W
Journal of Pharmaceutical Sciences, 96(1), 1-26 (2007)
Alberto Sinibaldi et al.
Biosensors, 8(3) (2018-07-26)
Optical biosensors based on one-dimensional photonic crystals sustaining Bloch surface waves are proposed to study antibody interactions and perform affinity studies. The presented approach utilizes two types of different antibodies anchored at the sensitive area of a photonic crystal-based biosensor....
Molecular Genetics of Immunoglobulin (1987)
In vitro efficacy of immuno-chemotherapy with anti-EGFR human Fab-Taxol conjugate on A431 epidermoid carcinoma cells.
Wang, et al.
Cancer Biology & Therapy, 6, 980-987 (2020)
Rasmus Lundquist et al.
Infection and immunity, 74(6), 3222-3231 (2006-05-23)
Immunoglobulins from individuals with immunity to malaria have a strong antiparasitic effect when transferred to Plasmodium falciparum malaria infected patients. One prominent target of antiparasitic antibodies is the merozoite surface antigen 3 (MSP-3). We have investigated the antibody response against...
Molecular imaging application of radioiodinated anti-EGFR human Fab to EGFR-overexpressing tumor xenografts
Xu N, et al.
Anticancer research, 29(10), 4005-4011 (2009)
A human Fab exclusively binding to the extracellular domain of LMP2A
Cao Q, et al.
Biochemical and biophysical research communications, 482(2), 226-231 (2017)
Cells lytically infected with Epstein-Barr virus are detected and separable by immunoglobulins from EBV-seropositive individuals
Bhaduri-McIntosh S and Miller G
Journal of Virological Methods, 137(1), 103-114 (2006)
Chuan Li et al.
Vaccine, 28(26), 4294-4300 (2010-05-04)
A safe and effective hantavirus vaccine is highly desirable since hantaviruses are distributed worldwide and cause an acute and often fatal disease (hemorrhagic fever with renal syndrome, HFRS). Virus-like particles (VLPs) displaying functional viral proteins could provide effective vaccines against...
Konrad Fischer et al.
Xenotransplantation, 27(1), e12560-e12560 (2019-10-09)
Cell surface carbohydrate antigens play a major role in the rejection of porcine xenografts. The most important for human recipients are α-1,3 Gal (Galactose-alpha-1,3-galactose) causing hyperacute rejection, also Neu5Gc (N-glycolylneuraminic acid) and Sd(a) blood group antigens both of which are...
Xiaoyu Zhang et al.
JCI insight, 4(2) (2019-01-25)
The antiinflammatory effects of i.v. Ig (IVIG) in the treatment of autoimmune disease are due, in part, to the Fc fragments of Ig aggregates. In order to capitalize on the known antiinflammatory and tolerogenic properties of Ig Fc aggregates, we...
Renjie Chen et al.
Molecular cancer therapeutics, 11(3), 594-603 (2011-12-16)
Nasopharyngeal carcinoma (NPC) is a major cause of cancer-related death in Southeast Asia and China. Metastasis and relapse are the primary cause of morbidity and mortality in NPC. Recent evidence suggests that the Epstein-Barr virus latent membrane protein 1 (LMP1)...

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