Showing 1-30 of 174 results for "F6892"
Mi Ran Yun et al.
EMBO molecular medicine, 11(12), e10581-e10581 (2019-10-22)
Clinical benefit of ALK tyrosine kinase inhibitors (ALK-TKIs) in ALK-rearranged lung cancer has been limited by the inevitable development of acquired resistance, and bypass-molecular resistance mechanisms remain poorly understood. We investigated a novel therapeutic target through screening FDA-approved drugs in...
Rui Watanabe et al.
Human brain mapping, 38(12), 6218-6229 (2017-09-21)
Imitative stimuli presented from a first-person perspective (FPP) produce stronger visuomotor effects than those presented from a third-person perspective (TPP) due to the relatively greater response of the mirror neuron system (MNS) to FPP stimuli. Some previous studies utilizing TPP...
Fengqi Li et al.
Plant, cell & environment, 41(1), 111-120 (2017-04-04)
Volatile terpenoids play a key role in plant defence against herbivory by attracting parasitic wasps. We identified seven terpene synthase genes from lima bean, Phaseolus lunatus L. following treatment with either the elicitor alamethicin or spider mites, Tetranychus cinnabarinus. Four...
Masanobu Tsubaki et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 78, 23-29 (2016-02-24)
Macrophage inflammatory protein-1alpha (MIP-1α) is detected at high concentrations in patients with multiple myeloma. It is thought to play an important role in the etiology of multiple myeloma and osteolysis. Thus, inhibiting MIP-1α expression may be useful in developing therapeutic...
Yanan Zhai et al.
Fungal genetics and biology : FG & B, 129, 7-15 (2019-04-14)
Eupenifeldin, a bistropolone meroterpenoid, was first discovered as an antitumor agent from the fungus Eupenicillium brefeldianum. We also isolated this compound and a new congener from a strain of Phoma sp. (CGMCC 10481), and evaluated their antitumor effects. Eupenifeldin showed...
Sindy Frick et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(11), 4194-4199 (2013-02-27)
Isoprenyl diphosphate synthases (IDSs) produce the ubiquitous branched-chain diphosphates of different lengths that are precursors of all major classes of terpenes. Typically, individual short-chain IDSs (scIDSs) make the C10, C15, and C20 isoprenyl diphosphates separately. Here, we report that the...
Mengyu Liu et al.
Functional plant biology : FPB, 47(5), 425-439 (2020-04-07)
D-limonene is the main component of citrus essential oils. In the monoterpene biosynthetic pathway, geranyl diphosphate reacts with monoterpenes to form the prenyl-carbocation intermediate to produce d-limonene. In this study, d-limonene synthase (FcLS) genes were first isolated from Rongan kumquat...
Xiang Li et al.
Journal of experimental botany, 68(17), 4929-4938 (2017-10-11)
The unique flavor of Citrus fruit depends on complex combinations of soluble sugars, organic acids, and volatile compounds. The monoterpene E-geraniol is an important volatile, contributing to flavor in sweet orange (Citrus sinensis Osbeck). Moreover, antifungal activity of E-geraniol has...
Miguel Moutinho et al.
Experimental cell research, 360(1), 55-60 (2017-02-25)
Cholesterol homeostasis greatly impacts neuronal function due to the essential role of this sterol in the brain. The mevalonate (MVA) pathway leads to the synthesis of cholesterol, but also supplies cells with many other intermediary molecules crucial for neuronal function....
Joanna Kopecka et al.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy, 49, 100670-100670 (2019-12-18)
Lipids, phospholipids and cholesterol in particular, are the predominant components of the plasma membrane, wherein multidrug efflux transporters of the ATP-binding cassette (ABC) superfamily reside as integral pump proteins. In the current review, we discuss how lipids potently modulate the...
Kota Kera et al.
The FEBS journal, 279(20), 3813-3827 (2012-08-14)
In eukaryotes, dolichols (C(70-120)) play indispensable roles as glycosyl carrier lipids in the biosynthesis of glycoproteins on endoplasmic reticulum. In addition to dolichols, seed plants have other types of Z,E-mixed polyisoprenoids termed ficaprenol (tri-trans,poly-cis-polyprenol, C(45-75)) and betulaprenol (di-trans,poly-cis-polyprenol, C(30-45) and...
Rakesh K Dhiman et al.
PloS one, 14(4), e0214958-e0214958 (2019-04-13)
The menaquinone biosynthetic pathway presents a promising drug target against Mycobacterium tuberculosis and potentially other Gram-positive pathogens. In the present study, the essentiality, steady state kinetics of MenA from M. tuberculosis and the mechanism of MenA inhibition by Ro 48-8071...
Sholeem Griffin et al.
Biology of reproduction, 99(4), 749-760 (2018-04-25)
Preventing postpartum uterine disease depends on the ability of endometrial cells to tolerate the presence of the bacteria that invade the uterus after parturition. Postpartum uterine disease and endometrial pathology in cattle are most associated with the pathogen Trueperella pyogenes....
Tingting Yao et al.
Nature communications, 9(1), 4091-4091 (2018-10-07)
Cyclodipeptide synthases (CDPSs) can catalyze the formation of two successive peptide bonds by hijacking aminoacyl-tRNAs from the ribosomal machinery resulting in diketopiperazines (DKPs). Here, three CDPS-containing loci (dmt1-3) are discovered by genome mining and comparative genome analysis of Streptomyces strains....
Tobiloba E Oni et al.
The Journal of experimental medicine, 217(9) (2020-07-08)
Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis, and new therapies are needed. Altered metabolism is a cancer vulnerability, and several metabolic pathways have been shown to promote PDAC. However, the changes in cholesterol metabolism and their role during PDAC...
Qin Pan et al.
Fundamental & clinical pharmacology, 34(1), 32-40 (2019-05-07)
Aberrant activation of GTPases is common in cervical cancer, and their proper biological functions largely depend on a post-translational modification termed prenylation. Simvastatin is a cholesterol-lowering drug via inhibiting HMG-CoA reductase, thereby inhibiting protein prenylation. In this study, we show...
Guo Wei et al.
Plant physiology, 172(1), 603-618 (2016-07-28)
Plant volatile organic compounds, which are generated in a tissue-specific manner, play important ecological roles in the interactions between plants and their environments, including the well-known functions of attracting pollinators and protecting plants from herbivores/fungi attacks. However, to date, there...
Sarah A Reigard et al.
Biochemistry, 44(33), 11214-11223 (2005-08-17)
Protein farnesyltransferase (FTase) catalyzes the post-translational modification of many important cellular proteins, and is a potential anticancer drug target. Crystal structures of the FTase ternary complex illustrate an unusual feature of this enzyme, the fact that the isoprenoid substrate farnesyl...
Petra M Bleeker et al.
Proceedings of the National Academy of Sciences of the United States of America, 109(49), 20124-20129 (2012-11-22)
Tomato breeding has been tremendously efficient in increasing fruit quality and quantity but did not focus on improving herbivore resistance. The biosynthetic pathway for the production of 7-epizingiberene in a wild tomato was introduced into a cultivated greenhouse variety with...
Caroline West et al.
Journal of chromatography. A, 1412, 126-138 (2015-08-19)
Pentafluorophenyl-bonded silica (PFP) phases employed in high-performance liquid chromatography (HPLC) often provide very different results depending on the column manufacturer. PFP phases also provide significantly different selectivity from non-fluorinated aromatic phases. As all HPLC columns can also be employed with...
Jingjing Jin et al.
Journal of experimental botany, 66(13), 3959-3975 (2015-05-10)
The pleasant fragrance of ylang ylang varieties (Cananga odorata) is mainly due to volatile organic compounds (VOCs) produced by the flowers. Floral scents are a key factor in plant-insect interactions and are vital for successful pollination. C. odorata var. fruticosa...
Stefan Tippmann et al.
ACS synthetic biology, 6(1), 19-28 (2016-08-26)
Enzyme fusions have been widely used as a tool in metabolic engineering to increase pathway efficiency by reducing substrate loss and accumulation of toxic intermediates. Alternatively, enzymes can be colocalized through attachment to a synthetic scaffold via noncovalent interactions. Here...
Identification of superior parental lines for biparental crossing via genomic prediction.
Chung, et al.
PLoS ONE, 15, e0243159-e0243159 (2021)
Shoubin Sun et al.
Journal of ophthalmology, 2015, 425438-425438 (2015-08-11)
Ocular siderosis is a common eye disease caused by retention of an iron-containing intraocular foreign body in the eye. Iron-containing intraocular foreign bodies may cause severe inflammatory reaction and affect visual function. Currently the optimal treatment method of ocular siderosis...
Iris Chiara Salaroglio et al.
Oncotarget, 6(2), 1128-1142 (2014-12-30)
The human malignant mesothelioma (HMM) is characterized by a chemoresistant and immunosuppressive phenotype. An effective strategy to restore chemosensitivity and immune reactivity against HMM is lacking. We investigated whether the use of zoledronic acid is an effective chemo-immunosensitizing strategy. We...
Yiqun G Shellman et al.
Melanoma research, 15(2), 83-89 (2005-04-23)
The cholesterol-lowering medications, statins, inhibit cellular proliferation and induce apoptosis in an array of cancer cell lines, including melanoma. We investigated the apoptotic mechanism of lovastatin on human melanoma cell lines in vitro. The cytotoxicity of statins on multiple cell...
Farhat Abbas et al.
Planta, 249(1), 71-93 (2018-09-16)
Floral scent formation in Lilium 'Siberia' is mainly due to monoterpene presence in the floral profile. LoTPS1 and LoTPS3 are responsible for the formation of (±)-linalool and β-ocimene in Lilium 'Siberia'. Lilium 'Siberia' is a perennial herbaceous plant belonging to...
Gregory J Reynolds et al.
Plants (Basel, Switzerland), 8(7) (2019-07-25)
Systemic acquired resistance (SAR) is a mechanism through which plants may respond to initial challenge by a pathogen through activation of inducible defense responses, thereby increasing resistance to subsequent infection attempts. Fitness costs are assumed to be incurred by plants...
Yong-Lei Zhang et al.
Archives of insect biochemistry and physiology, 81(2), 63-76 (2012-06-15)
Short-chain prenyltransferases are responsible for biosynthesis of the C(10)-C(20) precursors of a variety of isoprenoids. We previously isolated two different short-chain prenyltransferases from the green peach aphid, Myzus persicae (MpIPPS1 and MpIPPS2). In this study, the activity of the two...
Marta Pontremoli et al.
Scientific reports, 8(1), 16671-16671 (2018-11-14)
This study shows that DKK-1, a member of the Dickkopf family and a regulator of the Wnt pathways, represents a novel target of statins which, through the inhibition of HMG-CoA reductase and of non-steroidal isoprenoid intermediates, exert extra-beneficial effect in...

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