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Pengfei Cui et al.
Food & function, 11(5), 4403-4415 (2020-05-07)
In order to avoid the discomfort of digesting milk protein and make full use of the gastrointestinal digestive function, a milk macromolecular peptide was prepared with ACE inhibitory activity after gastrointestinal digestion as the index. Then, the antihypertensive activity of
Maguire, G.A. and Price, C.P., Ann
Clinical Biochemistry, 22, 204-204 (1985)
Tarik Akar
Revista da Associacao Medica Brasileira (1992), 64(3), 224-229 (2018-04-12)
Chronic hepatitis C (CHC) continues to be a critical problem. The liver fibrosis score is the most valuable tool in determining treatment and prognosis. Liver biopsy is still considered a gold method but, due to unmet needs, new non-invasive markers
Anna Rita Tondo et al.
Journal of agricultural and food chemistry, 68(2), 541-548 (2019-12-21)
Besides their nutritional value, whey protein (WP) peptides are food components retaining important pharmacological properties for controlling hypertension. We herein report how the use of complementary experimental and theoretical investigations allowed the identification of novel angiotensin converting enzyme inhibitory (ACEI)
Hankie Uluko et al.
Journal of the science of food and agriculture, 94(12), 2420-2428 (2014-01-15)
The use of power ultrasound as a pretreatment to enhance the hydrolysis of milk protein concentrate (MPC) and subsequent angiotensin converting enzyme (ACE) inhibitory activity has been studied. Liquid chromatography was used to analyse peptide profiles of Neutrase-derived MPC hydrolysates
Yuchen Guo et al.
Molecules (Basel, Switzerland), 24(8) (2019-04-28)
Pterygoplichthys disjunctivus, locally named the armoured catfish, is a by-catch of tilapia fishing that accounts for up to 80% of total captured fish in the Adolfo Lopez Mateos dam, in Michoacán, México, affecting the economy of its surrounding communities. This
Hui-Ling Chen et al.
Micron (Oxford, England : 1993), 41(6), 674-685 (2010-04-30)
The somatic angiotensin I-converting enzyme (sACE; peptidyl-dipeptidase A; EC was isolated from pig lung and purified to homogeneity. The purified enzyme has a molecular mass of about 180 kDa. Upon proteolytic cleavage, two approximately 90 kDa fragments were obtained
Hsin-Chieh Lin et al.
Food & nutrition research, 61(1), 1391666-1391666 (2017-11-21)
Proteins from tilapia frame and skin can potentially be precursors of antihypertensive peptides according to the result of BIOPEP analyses. The aim was to generate peptides with inhibitory effects against angiotensin-converting enzyme (ACE) and renin from tilapia frame and skin protein
Aslaug Drotningsvik et al.
The British journal of nutrition, 120(7), 740-750 (2018-08-30)
Obesity increases the risk for developing kidney disease, and protection of kidneys through changes in diet should be investigated. Fish intake has been associated with reduced risk of developing kidney disease; therefore, we wanted to investigate whether cod protein intake
Jing-Yuan Xu et al.
Journal of translational medicine, 19(1), 91-91 (2021-03-01)
Midkine is a multi-functional molecule participating in a various key pathological process. We aimed to evaluate the change of midkine in sepsis and its association with angiotensin-converting enzyme (ACE) system, as well as the mechanism by which midkine induced in
Peter V Binevski et al.
FEBS letters, 550(1-3), 84-88 (2003-08-26)
The somatic isoform of angiotensin-converting enzyme (ACE) consists of two homologous domains (N- and C-domains), each bearing a catalytic site. We have used the two-domain ACE form and its individual domains to compare characteristics of different domains and to probe
Songmin Cao et al.
Journal of agricultural and food chemistry, 68(3), 759-768 (2019-12-17)
In this study, we investigated the antihypertensive effects in vitro and in vivo of novel angiotensin-converting enzyme inhibitory (ACEI) peptides purified and identified from bovine bone gelatin hydrolysate (BGH). Thirteen ACEI peptides were identified from BGH, and among which, RGL-(Hyp)-GL
M Stepien et al.
Chronobiology international, 10(5), 331-337 (1993-10-01)
Angiotensin-converting enzyme (ACE) activity in serum and lung tissue from both normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR) was determined at six different circadian times. In WKY rats serum ACE varied significantly within 24 h, mainly due to reduced
Zhen-Hao Li et al.
Scientific reports, 7(1), 12243-12243 (2017-09-28)
Quality control is critical for ensuring the safety and effectiveness of drugs. Current quality control method for botanical drugs is mainly based on chemical testing. However, chemical testing alone may not be sufficient as it may not capture all constituents
Xue Wang et al.
Virology, 533, 137-144 (2019-06-28)
Angiotensin-converting enzyme (ACE) plays diverse roles in the animal kingdom. However, whether ACE plays an immune function against viral infection in vector insects is unclear. In this study, an ACE gene (LsACE) from the small brown planthopper was found to
Fatma Beyazit et al.
Archives of gynecology and obstetrics, 292(2), 415-420 (2015-02-20)
Clinicopathologic and molecular studies have provided new insights and understanding on the pathological events during ovarian carcinogenesis. Moreover, angiotensin II-enhanced tumor cell invasion via type 1 angiotensin II receptor in ovarian cancer cell lines was recently demonstrated. It has been
Xue Yang et al.
Food chemistry, 331, 127216-127216 (2020-07-11)
The effects of ultrasound working modes using multi-mode S-type ultrasound on the preparation of bioactive peptide from rice protein (RP) were studied with the ACE inhibitory activity of protein-hydrolysate after gastrointestinal simulated digestion as the index. The structure characterizations of
M Bramucci et al.
Biochemistry and molecular biology international, 47(1), 107-115 (1999-03-27)
This study was conducted to determine the presence of the angiotensin converting enzyme in commercial sera used in cell culture medium. The aim of the research was to bring the presence of proteinases (angiotensin converting enzyme) to cell culture users'
Luana Quassinti et al.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 146(1), 119-123 (2006-11-04)
Angiotensin converting enzyme (ACE) is the dipeptidyl-carboxypeptidase of the renin-angiotensin system involved in the control of blood pressure and hydromineral metabolism. It converts angiotensin I to angiotensin II, the biologically active octapeptide. Angiotensin converting enzyme-like activity has been demonstrated in
E Villard et al.
American journal of human genetics, 58(6), 1268-1278 (1996-06-01)
Plasma angiotensin I-converting enzyme (ACE) levels are highly genetically determined. A previous segregation-linkage analysis suggested the existence of a functional mutation located within or close to the ACE locus, in almost complete linkage desequilibrium (LD) with the ACE insertion/deletion (I/D)
Zehra Basi et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1104, 190-195 (2018-12-07)
Angiotensin converting enzyme (ACE, peptidyldipeptidase A, EC plays an important role in the regulation of blood pressure. In this study, ACE was purified from human plasma by affinity chromatography in single step. The enzyme purified in 5367-fold from human
G O Evans
Jikken dobutsu. Experimental animals, 38(2), 163-164 (1989-04-01)
Angiotensin converting enzyme (ACE; EC activities were compared in plasma samples obtained from three species using a furanacryloyl tripeptide substrate. The enzyme activity observed in Wistar rat plasma was higher than the activities observed in the other two species.
Yu Fu et al.
International journal of biological macromolecules, 101, 207-213 (2017-03-17)
In this work, the inhibitory effects of potato patatin-derived peptides Trp-Gly (WG) and Pro-Arg-Tyr (PRY) on angiotensin I-converting enzyme (ACE) and renin activities were investigated using kinetics, intrinsic fluorescence and molecular docking. The results indicated that PRY was a more
Anees A Syed et al.
Journal of ethnopharmacology, 193, 555-565 (2016-10-11)
Ulmus wallichiana Planchon (Himalayan Elm), a traditional medicinal plant, used in fracture healing in folk tradition of Uttarakhand, Himalaya, India. It is also used as diuretic. U. rhynchophylla, native to China, known as Gou Teng in Chinese medicine, is used
P P Golikov et al.
Klinicheskaia laboratornaia diagnostika, (1)(1), 11-13 (1998-04-09)
A simple and rapid spectrophotometric procedure is developed for measuring the activity of angiotensin-converting enzyme (ACE) in human serum. Furylacryloyl-phenylalanyl-glycyl-glycine (FAPGG) possessing a high absorption capacity at 334 nm was used as the substrate. ACE hydrolyzes FAPGG and decreases the
Abraham T Girgih et al.
Food & nutrition research, 59, 29788-29788 (2015-12-31)
Cod muscle has a balanced protein profile that contains potentially bioactive amino acid sequences. However, there is limited information on release of these peptides from the parent proteins and their ability to modulate mammalian blood pressure. The aim of this
G Uçar et al.
Biochemical pharmacology, 44(3), 565-570 (1992-08-04)
The steady-state inhibition of bovine lung angiotensin converting enzyme (ACE; EC by the slow-binding inhibitor lisinopril and its dansyl derivative conformed to a linear mixed inhibition model with inhibitor binding to ES as well as to E. Studied at
S Métayer et al.
Biology of reproduction, 65(5), 1332-1339 (2001-10-24)
The 94-kDa ram epididymal fluid form of the sperm membrane-derived germinal angiotensin I-converting enzyme (ACE) was purified by chromatography, and some of its enzymatic properties were studied. For the artificial substrate furanacryloyl-L-phenylalanylglycylglycine (FAPGG), the enzyme exhibited a Michaelis constant (K(m))
J E Buttery et al.
Clinical chemistry, 39(2), 312-316 (1993-02-01)
In the kinetic angiotensin-converting enzyme (ACE) method, a practical and optimal buffer is 80 mmol/L borate buffer at pH 8.2 (37 degrees C). A lag phase is detected in the reaction, and a 5-min incubation of substrate and plasma is
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