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F7250

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Jian Zhang et al.
PloS one, 10(3), e0121282-e0121282 (2015-03-31)
Megalocytivirus is a DNA virus with a broad host range among teleost fish. Although the complete genome sequences of a number of megalocytivirus isolates have been reported, the functions of most of the genes of this virus are unknown. In...
Ravi K Garg et al.
Stem cells translational medicine, 3(9), 1079-1089 (2014-07-20)
Effective skin regeneration therapies require a successful interface between progenitor cells and biocompatible delivery systems. We previously demonstrated the efficiency of a biomimetic pullulan-collagen hydrogel scaffold for improving bone marrow-derived mesenchymal stem cell survival within ischemic skin wounds by creating...
Xuemei Fan et al.
Blood, 124(15), 2421-2430 (2014-07-31)
Murine paired immunoglobulin-like receptors B (PIRB), as the ortholog of human leukocyte immunoglobulin-like receptor B2 (LILRB2), is involved in a variety of biological functions. Here, we found that PIRB and LILRB2 were expressed in mouse and human platelets, respectively. PIRB...
Lele Guo et al.
PloS one, 10(4), e0124002-e0124002 (2015-04-14)
Treatment of systemic lupus erythematosus (SLE), a chronic inflammatory disease, involves the long-term use of immunosuppressive agents with significant side effects. New therapeutic approaches are being explored to find better treatment possibilities. In this study, age-matched female MRL/lpr mice were...
Jonathan L Berkowitz et al.
Clinical immunology (Orlando, Fla.), 155(2), 176-187 (2014-10-01)
Interleukin-2 receptor α chain (CD25) is overexpressed in human T-cell leukemia virus 1 associated adult T-cell leukemia/lymphoma (ATL). Daclizumab a humanized monoclonal antibody blocks IL-2 binding by recognizing the interleukin-2 receptor α chain (CD25). We conducted a phase I/II trial...
A M Vieira et al.
Biochemical pharmacology, 90(4), 388-396 (2014-06-03)
Lipoxins (LX) and 15-epi-LX are lipids with a potent inhibitory effect on angiogenesis, in different models in vivo and in vitro. ATL-1, a synthetic analog of 15-epi-LXA4, inhibits various actions stimulated by vascular endothelial growth factor (VEGF). However, LX actions...
Jannatul Firdous et al.
Acta biomaterialia, 10(11), 4606-4617 (2014-08-12)
Respiratory syncytial virus (RSV) is one of the most common causes of viral deaths in infants worldwide, yet no effective vaccines are available. Here, we report an osmotically active polysaccharide-based polysorbitol transporter (PST) prepared from sorbitol diacrylate and low-molecular-weight polyethylenimine...
Oi-Wing Ng et al.
PloS one, 9(7), e102415-e102415 (2014-07-16)
The Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) is the etiological agent for the infectious disease, SARS, which first emerged 10 years ago. SARS-CoV is a zoonotic virus that has crossed the species barriers to infect humans. Bats, which harbour a...
Yeri Alice Rim et al.
Scientific reports, 4, 6935-6935 (2014-11-07)
Cytotoxic T lymphocyte-associated antigen 4 immunoglobulin fusion protein (CTLA4Ig, abatacept) is a B7/CD28 costimulation inhibitor that can ward off the immune response by preventing the activation of naïve T cells. This therapeutic agent is administered to patients with autoimmune diseases...
Bina Menon et al.
Arthritis & rheumatology (Hoboken, N.J.), 66(5), 1272-1281 (2014-01-29)
Psoriatic arthritis (PsA) is associated with HLA class I genes, in contrast to the association with HLA class II in rheumatoid arthritis (RA). Since IL-17+ cells are considered important mediators of synovial inflammation, we sought to determine whether IL-17-producing CD8+...
Limin Gu et al.
Investigative ophthalmology & visual science, 55(12), 8208-8222 (2014-10-23)
Retinal neuronal cell dysfunction and even cell death are associated with increased excitotoxic glutamate (Glu) level in the retina. Our aim was to study a causative mechanism of Glu on retinal cell death and explore the neuroprotective role of erythropoietin...
Zheng-Jie Huang et al.
Molecular medicine reports, 11(3), 1647-1654 (2014-11-19)
Breast cancer is the most common type of malignancy among females. Previous studies examining breast cancer tissue have demonstrated the presence of stem cells, and have detected octamer‑binding protein 4 (Oct4) and Nanog transcription factor expression. In the present study...
Anamika Dhyani et al.
European journal of cancer (Oxford, England : 1990), 51(2), 252-259 (2014-12-09)
ANKHD1 (Ankyrin repeat and KH domain-containing protein 1) is highly expressed and plays an important role in the proliferation and cell cycle progression of multiple myeloma (MM) cells. ANKHD1 downregulation modulates cell cycle gene expression and upregulates p21 irrespective of...
Tanwarat Sanvoranart et al.
Biochemical and biophysical research communications, 447(4), 580-585 (2014-04-22)
Bortezomib (BZB) is a chemotherapeutic agent approved for treating multiple myeloma (MM) patients. In addition, there are several reports showing that bortezomib can induce murine mesenchymal stem cells (MSCs) to undergo osteogenic differentiation and increase bone formation in vivo. MSCs...
Roberta Antonia Diotti et al.
Antiviral research, 108, 94-103 (2014-06-10)
JC virus (JCPyV) has gained novel clinical importance as cause of progressive multifocal leukoencephalopathy (PML), a rare demyelinating disease recently associated to immunomodulatory drugs, such as natalizumab used in multiple sclerosis (MS) cases. Little is known about the mechanisms leading...
Chien-Hao Huang et al.
Journal of gastroenterology and hepatology, 30(4), 775-783 (2014-09-25)
Patients with liver cirrhosis (LC) were regarded as immunocompromised status with high incidence of bacterial infection. Regulatory T cell (Treg cell) is known as an immune suppressor and also plays an important role in patients with sepsis. This paper aims...
Diana A Alvarez Arias et al.
Cancer immunology research, 2(3), 207-216 (2014-04-30)
Tumor growth is associated with the inhibition of host antitumor immune responses that can impose serious obstacles to cancer immunotherapy. To define the potential contribution of Qa-1-restricted CD8 regulatory T cells (Treg) to the development of tumor immunity, we studied...
Guohai Sun et al.
Journal of proteomics, 109, 199-211 (2014-07-20)
Protein lysine acetylation is a dynamic and reversible post-modification that is known to play diverse functions in eukaryotes. Nevertheless, the composition and function of non-histone lysine acetylation in gametes remain unknown. In humans, only capacitated sperm have the capacity to...
Renhui Zhan et al.
Infection and immunity, 83(4), 1641-1649 (2015-02-11)
Toll-like receptors (TLRs) are evolutionarily conserved host proteins that are essential for effective host defense against pathogens. However, recent studies suggest that some TLRs can negatively regulate immune responses. We observed here that TLR2 and TLR9 played opposite roles in...
K P Coss et al.
Molecular genetics and metabolism, 113(3), 177-187 (2014-09-02)
Classical Galactosaemia is a rare disorder of carbohydrate metabolism caused by a deficiency of galactose-1-phosphate uridyltransferase (GALT). The disease is life-threatening in the neonate, and the only treatment option is life-long dietary restriction of galactose. However, long-term complications persist in...
Young-Ho Lee et al.
Journal of controlled release : official journal of the Controlled Release Society, 199, 98-105 (2014-12-17)
Antigen-specific CD8(+) cytotoxic T lymphocytes (CTLs) are key elements of immunological rejection in transplantation as well as cancer immunotherapy. Most tumors, however, are not immunologically rejected because they have self antigens, which are not recognized as the foreigner by CTLs....
Elena Campello et al.
Thrombosis and haemostasis, 113(1), 85-96 (2014-10-17)
The role of circulating microparticles (MP) of different origin and tissue factor (TF)-bearing in overweight and obese patients with and without metabolic syndrome is still a matter of debate. In a case-control study, the presence of hypercoagulability was evaluated in...
Ester B M Remmerswaal et al.
Journal of virology, 89(1), 568-580 (2014-10-24)
Human cytomegalovirus (hCMV) infection is characterized by a vast expansion of resting effector-type virus-specific T cells in the circulation. In mice, interleukin-7 receptor α (IL-7Rα)-expressing cells contain the precursors for long-lived antigen-experienced CD8(+) T cells, but it is unclear if...
Anderson Silva Machado et al.
Mediators of inflammation, 2014, 910621-910621 (2014-10-21)
Toxoplasma gondii is the main infectious cause of human posterior retinochoroiditis, the most frequent clinical manifestation of congenital toxoplasmosis. This investigation was performed after neonatal screening to identify biomarkers of immunity associated with immunopathological features of the disease by flow...
Kristina R Wilhelm et al.
The FEBS journal, 281(3), 957-969 (2013-12-03)
Patients with acute lung injury are administered high concentrations of oxygen during mechanical ventilation, and while both hyperoxia and mechanical ventilation are necessary, each can independently cause additional injury. However, the precise mechanisms that lead to injury are not well...
Yulong Wu et al.
International journal of clinical and experimental pathology, 7(12), 8563-8572 (2015-02-13)
Pancreata from Sprague Dawley rats of different developmental stages were studied to determine the expression and cellular localization of different c-MET isoforms in the developing rat pancreas. Pancreatic mRNA and protein expression levels of c-MET at different developmental stages from...
Alžběta Mifková et al.
Chembiochem : a European journal of chemical biology, 15(10), 1465-1470 (2014-05-29)
Cancer-associated fibroblasts (CAFs) play a role in the progression of malignant tumors. They are formed by conversion of fibroblasts to smooth muscle α-actin-positive (SMA-positive) myofibroblasts. Polyamines are known to change the arrangement of the actin cytoskeleton by binding to the...
Sokhna M S Yakhine-Diop et al.
Toxicology, 324, 1-9 (2014-07-16)
Parkinson's disease (PD) is a neurodegenerative disorder of unknown etiology. It is considered as a multifactorial disease dependent on environmental and genetic factors. Deregulation in cell degradation has been related with a significant increase in cell damage, becoming a target...
Ran Luo et al.
Journal of neuroimmunology, 276(1-2), 58-63 (2014-08-31)
The pathogenesis of glioma is unclear. The therapeutic results are very poor currently. This study aims to investigate the endothelial cell-derived plasminogen in the promotion of glioma cell proliferation. The results showed that after exposure to polyIC, the production of...
Alanna Ruddell et al.
BMC cancer, 14, 354-354 (2014-06-03)
Tumors drive blood vessel growth to obtain oxygen and nutrients to support tumor expansion, and they also can induce lymphatic vessel growth to facilitate fluid drainage and metastasis. These processes have generally been studied separately, so that it is not...
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