Showing 1-30 of 2161 results for "F7425"
Junghyun Kim et al.
The Plant cell, 28(6), 1388-1405 (2016-06-16)
The bHLH transcription factor PHYTOCHROME INTERACTING FACTOR1 (PIF1) binds G-box elements in vitro and inhibits light-dependent germination in Arabidopsis thaliana A previous genome-wide analysis of PIF1 targeting indicated that PIF1 binds 748 sites in imbibed seeds, only 59% of which...
Kebing Wang et al.
Frontiers in oncology, 10, 575358-575358 (2020-11-03)
Overexpression of Golgi phosphoprotein 3 (GOLPH3) predicts poor prognosis and is a potential therapeutic target in pancreatic ductal adenocarcinoma (PDAC). However, its role and underlying molecular mechanisms in the progression of PDAC remain unknown. In the present study, using high-throughput...
Masako Koyama et al.
Protein science : a publication of the Protein Society, 26(9), 1870-1877 (2017-06-14)
WBSCR16 (Williams-Beuren Syndrome Chromosomal Region 16) gene is located in a large deletion region of Williams-Beuren syndrome (WBS), which is a neurodevelopmental disorder. Although the relationship between WBSCR16 and WBS remains unclear, it has been reported that WBSCR16 is a...
Yucheng Yao et al.
Circulation research, 102(9), 1065-1074 (2008-03-29)
Arterial calcification is ubiquitous in vascular disease and is, in part, prevented by matrix Gla protein (MGP). MGP binds calcium ions through gamma-carboxylated glutamates (Gla residues) and inhibits bone morphogenetic protein (BMP)-2/-4. We hypothesized that a conserved proline (Pro)64 is...
Silvia Biggi et al.
Journal of neurochemistry, 152(1), 136-150 (2019-07-03)
The vast majority of therapeutic approaches tested so far for prion diseases, transmissible neurodegenerative disorders of human and animals, tackled PrPSc , the aggregated and infectious isoform of the cellular prion protein (PrPC ), with largely unsuccessful results. Conversely, targeting...
Saya Ito et al.
The FEBS journal, 281(19), 4506-4518 (2014-08-19)
Androgen-independent prostate cancer is known as a hormone-refractory disease. Although the androgen receptor (AR) is considered to be a key regulator of androgen-independent prostate cancer progression, the mechanism through which AR gene expression is regulated is not well understood. In...
Ramhari Kumbhar et al.
Life science alliance, 1(3), e201800096-e201800096 (2018-11-21)
The DNA damage response (DDR) ensures cellular adaptation to genotoxic insults. In the crowded environment of the nucleus, the assembly of productive DDR complexes requires multiple protein modifications. How the apical E1 ubiquitin activation enzyme UBA1 integrates spatially and temporally...
Hanne Roberg-Larsen et al.
The Journal of steroid biochemistry and molecular biology, 169, 22-28 (2016-02-16)
Exosomes from cancer cells are rich sources of biomarkers and may contain elevated levels of lipids of diagnostic value. 27-Hydroxycholesterol (27-OHC) is associated with proliferation and metastasis in estrogen receptor positive (ER+) breast cancer. In this study, we investigated the...
Yan Jin et al.
Proceedings of the National Academy of Sciences of the United States of America, 114(28), 7408-7413 (2017-06-25)
The involvement of host factors is critical to our understanding of underlying mechanisms of transposition and the applications of transposon-based technologies. ModifiedpiggyBac(PB) is one of the most potent transposon systems in mammals. However, varying transposition efficiencies ofPBamong different cell lines...
Elisabeth Naschberger et al.
Journal of cellular and molecular medicine, 21(9), 1954-1966 (2017-03-09)
Human guanylate binding protein-1 (GBP-1) belongs to the family of large GTPases. The expression of GBP-1 is inducible by inflammatory cytokines, and the protein is involved in inflammatory processes and host defence against cellular pathogens. GBP-1 is the first GTPase...
Madeleine Strickland et al.
Nature communications, 8(1), 1391-1391 (2017-11-11)
HIV-1 replication requires Tsg101, a component of cellular endosomal sorting complex required for transport (ESCRT) machinery. Tsg101 possesses an ubiquitin (Ub) E2 variant (UEV) domain with a pocket that can bind PT/SAP motifs and another pocket that can bind Ub....
Xiaolong Tang et al.
Cancer research, 73(20), 6206-6218 (2013-09-07)
Adhesion G-protein-coupled receptors (GPCR), which contain adhesion domains in their extracellular region, have been found to play important roles in cell adhesion, motility, embryonic development, and immune response. Because most adhesion molecules with adhesion domains have vital roles in cancer...
Gavin R Oliver et al.
PloS one, 16(5), e0250518-e0250518 (2021-05-26)
Gestational trophoblastic disease (GTD) is a heterogeneous group of lesions arising from placental tissue. Epithelioid trophoblastic tumor (ETT), derived from chorionic-type trophoblast, is the rarest form of GTD with only approximately 130 cases described in the literature. Due to its...
Jiong Li et al.
Nature communications, 8, 15146-15146 (2017-04-26)
Human colorectal cancer stem cells (CSCs) are tumour initiating cells that can self-renew and are highly tumorigenic and chemoresistant. While genetic mutations associated with human colorectal cancer development are well-known, little is known about how and whether epigenetic factors specifically...
Peng Li et al.
eLife, 5 (2016-07-06)
Bile is an important component of the human gastrointestinal tract with an essential role in food absorption and antimicrobial activities. Enteric bacterial pathogens have developed strategies to sense bile as an environmental cue to regulate virulence genes during infection. We...
Zhongle Liu et al.
Antimicrobial agents and chemotherapy, 61(11) (2017-08-16)
Long-term azole treatment of patients with chronic Candida albicans infections can lead to drug resistance. Gain-of-function (GOF) mutations in the transcription factor Mrr1 and the consequent transcriptional activation of MDR1, a drug efflux coding gene, is a common pathway by...
Yasushi Shiomi et al.
Molecular and cellular biology, 32(12), 2279-2288 (2012-04-12)
Recent work identified the E3 ubiquitin ligase CRL4(Cdt2) as mediating the timely degradation of Cdt1 during DNA replication and following DNA damage. In both cases, proliferating cell nuclear antigen (PCNA) loaded on chromatin mediates the CRL4(Cdt2)-dependent proteolysis of Cdt1. Here...
Harshvardhan Rolyan et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(34), 12002-12017 (2015-08-28)
Lamin B1 is a component of the nuclear lamina and plays a critical role in maintaining nuclear architecture, regulating gene expression and modulating chromatin positioning. We have previously shown that LMNB1 gene duplications cause autosomal dominant leukodystrophy (ADLD), a fatal...
Thomas P Zwaka et al.
Disease models & mechanisms, 14(6) (2021-06-25)
Spinocerebellar ataxias (SCAs) are a group of genetically heterogeneous inherited neurodegenerative disorders characterized by progressive ataxia and cerebellar degeneration. Here, we used a mouse model to test a possible connection between SCA and Ronin (Thap11), a polyglutamine-containing transcriptional regulator encoded...
Anna Tsuchiya et al.
Journal of natural medicines, 74(4), 758-766 (2020-07-11)
Since Notch signaling plays important roles in cell proliferation and differentiation, aberrant activation of this signaling contributes to cancer progression. In neural stem cells, Notch signaling inhibits differentiation by activating HES1 expression. Therefore, Notch signaling inhibitors may be candidates for...
Qing Fan et al.
Journal of virology, 88(11), 6470-6482 (2014-03-29)
To gain insight into the mechanism of herpesvirus entry into cells, the four glycoproteins that are necessary for herpes simplex virus (HSV) fusion were cloned from the saimiriine herpesvirus 1 (SaHV-1) genome, a primate member of the alphaherpesvirus family. Cell-cell...
Thorsten Fritzius et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 37(5), 1162-1175 (2016-12-23)
GABAB receptors are the G-protein coupled receptors for the main inhibitory neurotransmitter in the brain, GABA. GABAB receptors were shown to associate with homo-oligomers of auxiliary KCTD8, KCTD12, KCTD12b, and KCTD16 subunits (named after their T1 K+-channel tetramerization domain) that...
Shulin Tang et al.
Biochemical pharmacology, 166, 12-22 (2019-05-11)
The type B trichothecene mycotoxin deoxynivalenol (DON), colloquially known as "vomitoxin", is the most commonly detected trichothecene in cereal-based foods, exerting acute and chronic toxic effects on animals and causing serious safety-related concerns. At the cellular and molecular levels, DON...
Woo-Jeong Jeong et al.
Nature communications, 10(1), 295-295 (2019-01-19)
Stability regulation of RAS that can affect its activity, in addition to the oncogenic mutations, occurs in human cancer. However, the mechanisms for stability regulation of RAS involved in their activity and its roles in tumorigenesis are poorly explored. Here...
Kévin Jacquet et al.
Molecular & cellular proteomics : MCP, 17(10), 1979-1990 (2018-07-14)
Signals from cell surface receptors are often relayed via adaptor proteins. NCK1 and NCK2 are Src-Homology (SH) 2 and 3 domain adaptors that regulate processes requiring a remodeling of the actin cytoskeleton. Evidence from gene inactivation in mouse suggests that...
Y Li et al.
Cell death and differentiation, 15(12), 1941-1951 (2008-09-23)
WWP1 E3 ubiquitin ligase has previously been shown to be frequently amplified and overexpressed in prostate and breast cancers. However, the mechanism of WWP1 action is still largely unknown. p63, a member of the p53 family of transcription factors, has...
Michela Palmieri et al.
Nature communications, 8, 14338-14338 (2017-02-07)
Neurodegenerative diseases characterized by aberrant accumulation of undigested cellular components represent unmet medical conditions for which the identification of actionable targets is urgently needed. Here we identify a pharmacologically actionable pathway that controls cellular clearance via Akt modulation of transcription...
Qingli Niu et al.
The Journal of clinical investigation, 129(8), 3361-3373 (2019-07-23)
HIV integrates its provirus into the host genome and establishes latent infection. Antiretroviral therapy (ART) can control HIV viremia, but cannot eradicate or cure the virus. Approaches targeting host epigenetic machinery to repress HIV, leading to an aviremic state free...
Chien-Po Liao et al.
Neuron, 98(2), 320-334 (2018-04-21)
Self-avoidance allows sister dendrites from the same neuron to form non-redundant coverage of the sensory territory and is important for neural circuitry functions. Here, we report an unexpected, cell-autonomous role of the Wnt-secretory factor MIG-14/Wntless in mediating dendrite self-avoidance in...
Denghui Wei et al.
Cell research, 31(2), 157-177 (2020-09-23)
Exosomes are generated within the multivesicular endosomes (MVEs) as intraluminal vesicles (ILVs) and secreted during the fusion of MVEs with the cell membrane. The mechanisms of exosome biogenesis remain poorly explored. Here we identify that RAB31 marks and controls an...

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