Showing 1-30 of 2161 results for "


Pamela Bella et al.
EMBO molecular medicine, 12(1), e11019-e11019 (2019-12-04)
Duchenne muscular dystrophy (DMD) is a debilitating fatal X-linked muscle disorder. Recent findings indicate that IGFs play a central role in skeletal muscle regeneration and development. Among IGFs, insulinlike growth factor 2 (IGF2) is a key regulator of cell growth...
Dannielle D Engle et al.
Science (New York, N.Y.), 364(6446), 1156-1162 (2019-06-22)
Glycosylation alterations are indicative of tissue inflammation and neoplasia, but whether these alterations contribute to disease pathogenesis is largely unknown. To study the role of glycan changes in pancreatic disease, we inducibly expressed human fucosyltransferase 3 and β1,3-galactosyltransferase 5 in...
Min-Woo Jeong et al.
Molecular biology of the cell, 24(3), 373-384 (2012-12-12)
Mitogen-activated protein kinase phosphatase 2 (MKP2) is a member of the dual-specificity MKPs that regulate MAP kinase signaling. However, MKP2 functions are still largely unknown. In this study, we showed that MKP2 could regulate histone H3 phosphorylation under oxidative stress...
Yeu-Yang Tseng et al.
Journal of virology, 89(22), 11619-11629 (2015-09-12)
Double-stranded RNA (dsRNA)-activated protein kinase (PKR), a major component of the cellular antiviral system, is activated by the binding of either dsRNA or the cellular PKR activator, the PACT protein. The suppression of PKR activation is one of the main...
Jyoti Adlakha et al.
Structure (London, England : 1993), 27(3), 464-475 (2019-01-08)
Membrane-bound coiled-coil proteins are important mediators of signaling, fusion, and scaffolding. Here, we delineate a heterogeneous group of trimeric membrane-anchored proteins in prokaryotes and eukaryotic organelles with a characteristic head-neck-stalk-anchor architecture, in which a membrane-anchored coiled-coil stalk projects an N-terminal...
Haruka Chino et al.
Molecular cell, 74(5), 909-921 (2019-04-23)
Certain proteins and organelles can be selectively degraded by autophagy. Typical substrates and receptors of selective autophagy have LC3-interacting regions (LIRs) that bind to autophagosomal LC3 and GABARAP family proteins. Here, we performed a differential interactome screen using wild-type LC3B...
Rong-Si Wu et al.
Oncotarget, 8(24), 39401-39416 (2017-04-30)
Great progress has been achieved in the study of the role of TGF-β signaling in triggering epithelial-mesenchymal transition (EMT) in a variety of cancers; however, the regulation of TGF-β signaling during EMT in mammary tumor metastasis has not been completely...
Gaëlle Loubeau et al.
PloS one, 9(5), e96293-e96293 (2014-05-07)
The chaperone nucleophosmin (NPM1) is over-expressed in the epithelial compartment of prostate tumours compared to adjacent healthy epithelium and may represent one of the key actors that support the neoplastic phenotype of prostate adenocarcinoma cells. Yet, the mechanisms that underlie...
Sarah Kit Leng Lui et al.
EMBO reports, 18(5), 797-808 (2017-04-07)
The amplitude of transforming growth factor-β (TGF-β) signal is tightly regulated to ensure appropriate physiological responses. As part of negative feedback loop SMAD7, a direct transcriptional target of downstream TGF-β signaling acts as a scaffold to recruit the E3 ligase...
Dorthe H Larsen et al.
Nature cell biology, 16(8), 792-803 (2014-07-30)
Chromosome breakage elicits transient silencing of ribosomal RNA synthesis, but the mechanisms involved remained elusive. Here we discover an in trans signalling mechanism that triggers pan-nuclear silencing of rRNA transcription in response to DNA damage. This is associated with transient...
Isabella Farhy-Tselnicker et al.
Neuron, 96(2), 428-445 (2017-10-13)
The generation of precise synaptic connections between developing neurons is critical to the formation of functional neural circuits. Astrocyte-secreted glypican 4 induces formation of active excitatory synapses by recruiting AMPA glutamate receptors to the postsynaptic cell surface. We now identify...
Nirodhini S Siriwardana et al.
Cell cycle (Georgetown, Tex.), 13(12), 1885-1901 (2014-04-18)
HAT HBO1 interacts with 2 isoforms of JADE1: JADE1S and JADE1L. JADE1 promotes acetylation of nucleosomal histones by HBO1. HBO1-JADE1 complex facilitates cell proliferation by unclear mechanisms. Here we report intracellular chromatin shuttling of HBO1-JADE1 complex during mitosis coupled to...
A kindred with mutant IKAROS and autoimmunity.
Erika Van Nieuwenhove et al.
The Journal of allergy and clinical immunology, 142(2), 699-702 (2018-05-01)
Robert F Niescier et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 38(20), 4666-4677 (2018-04-25)
Mitochondrial Ca2+ uptake is gated by the mitochondrial calcium uniplex, which is comprised of mitochondrial calcium uniporter (MCU), the Ca2+ pore-forming subunit of the complex, and its regulators. Ca2+ influx through MCU affects both mitochondrial function and movement in neurons...
Ning Lei et al.
Neuron, 96(6), 1303-1316 (2017-12-12)
NMDA receptors (NMDARs) are a subtype of postsynaptic ionotropic glutamate receptors that function as molecular coincidence detectors, have critical roles in models of learning, and are associated with a variety of neurological and psychiatric disorders. To date, no auxiliary proteins...
Nikolaos Charlaftis et al.
The EMBO journal, 33(21), 2581-2596 (2014-09-28)
Unlike the other MAP3Ks, MEKK1 (encoded by Map3k1) contains a PHD motif. To understand the role of this motif, we have created a knockin mutant of mouse Map3k1 (Map3k1(m) (PHD)) with an inactive PHD motif. Map3k1(m) (PHD) ES cells demonstrate...
Malgorzata Borkowska et al.
PloS one, 11(5), e0156082-e0156082 (2016-06-01)
Disrupted-in-Schizophrenia-1 (DISC1) gene has been linked to schizophrenia and related major mental illness. Mouse Disc1 has been implicated in brain development, mainly in the proliferation, differentiation, lamination, neurite outgrowth and synapse formation and maintenance of cortical excitatory neurons. Here, the...
Paul M Evans et al.
Molecular and cellular biology, 30(2), 372-381 (2009-11-11)
Wnt signaling is crucial in the organization and maintenance of the human intestinal epithelium, and somatic mutations that result in deregulated Wnt signaling are an early event in the development of colorectal cancer. The Wnt ligand ultimately results in the...
Liping Qian et al.
Biochemical and biophysical research communications, 498(4), 891-897 (2018-03-17)
Type-I interferons (IFN-I) are widely used for antiviral immunotherapy in clinic. Therefore, identification of the regulators of IFN-I antiviral activity is important for developing novel targets for IFN-based antiviral therapy. Monocyte chemoattractant protein 1-induced protein 1 (MCPIP1) is critical for...
Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.
V??lot, et al.
Molecular and Cellular Proteomics, 20, 100064-100064 (2021)
Masashi Yamaji et al.
Nature, 543(7646), 568-572 (2017-03-16)
The vertebrate-conserved RNA-binding protein DND1 is required for the survival of primordial germ cells (PGCs), as well as the suppression of germ cell tumours in mice. Here we show that in mice DND1 binds a UU(A/U) trinucleotide motif predominantly in...
Martin S Taylor et al.
The Journal of biological chemistry, 288(45), 32211-32228 (2013-09-21)
Ghrelin O-acyltransferase (GOAT) is a polytopic integral membrane protein required for activation of ghrelin, a secreted metabolism-regulating peptide hormone. Although GOAT is a potential therapeutic target for the treatment of obesity and diabetes and plays a key role in other...
Huiling He et al.
Thyroid : official journal of the American Thyroid Association, 30(2), 204-213 (2020-01-14)
Background: Our genome sequencing analysis revealed a frameshift mutation in the shelterin gene TINF2 in a large family with individuals affected with papillary thyroid carcinoma (PTC) and melanoma. Here, we further characterized the mutation and screened for coding variants in...
Hongjie Xia et al.
Cell reports, 33(1), 108234-108234 (2020-09-28)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication and host immune response determine coronavirus disease 2019 (COVID-19), but studies evaluating viral evasion of immune response are lacking. Here, we use unbiased screening to identify SARS-CoV-2 proteins that antagonize type I...
Madhu Sudhan Ravindran et al.
PLoS pathogens, 11(8), e1005086-e1005086 (2015-08-06)
Mammalian cytosolic Hsp110 family, in concert with the Hsc70:J-protein complex, functions as a disaggregation machinery to rectify protein misfolding problems. Here we uncover a novel role of this machinery in driving membrane translocation during viral entry. The non-enveloped virus SV40...
Santhilal Subhash et al.
Nucleic acids research, 46(18), 9384-9400 (2018-07-17)
Recently lncRNAs have been implicated in the sub-compartmentalization of eukaryotic genome via genomic targeting of chromatin remodelers. To explore the function of lncRNAs in the maintenance of active chromatin, we characterized lncRNAs from the chromatin enriched with H3K4me2 and WDR5...
Yan Jin et al.
Proceedings of the National Academy of Sciences of the United States of America, 114(28), 7408-7413 (2017-06-25)
The involvement of host factors is critical to our understanding of underlying mechanisms of transposition and the applications of transposon-based technologies. ModifiedpiggyBac(PB) is one of the most potent transposon systems in mammals. However, varying transposition efficiencies ofPBamong different cell lines...
Wenjing Liu et al.
Scientific reports, 10(1), 1804-1804 (2020-02-06)
Breast cancer patients often suffer from disease relapse and metastasis due to the presence of breast cancer stem-like cells (BCSCs). Numerous studies have reported that high levels of inflammatory factors, including tumor necrosis factor alpha (TNF-α), promote BCSCs. However, the...