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J Efraim Oosterink et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 998-999, 106-113 (2015-07-22)
Methionine, homocysteine, vitamins B6, B12, B9, and their metabolites are crucial co-factors and substrates for many basic biological pathways including one-carbon metabolism, and they are particularly important for brain function and development and epigenetic mechanisms. These are essential nutrients that...
Novel water-borne polyurethane nanomicelles for cancer chemotherapy: higher efficiency of folate receptors than TRAIL receptors in a Cancerous Balb/C Mouse Model.
Ajorlou E, et al.
Pharmaceutical Research, 33(6), 1426-1439 (2016)
Akiko Nanri
Journal of epidemiology, 23(4), 243-250 (2013-06-12)
In Japan, the prevalences of type 2 diabetes and depression are increasing, but evidence linking these diseases to diet is limited. The present study reviewed the association of type 2 diabetes with intakes of rice, fish/seafood, and soy product and...
BP targets in renal transplant recipients: too high or too low?
Hallvard Holdaas et al.
Journal of the American Society of Nephrology : JASN, 25(7), 1371-1373 (2014-03-15)
Yazheng Liu et al.
Food chemistry, 194, 26-31 (2015-10-17)
Folate deficiency is linked to many diseases, some of which may have higher probability in individuals with alcohol-induced alterations in one-carbon metabolism. Our study shows that folate content in commercial wine is not related to white or red varieties, but...
Maternal prenatal folic acid supplementation is associated with a reduction in development of autistic disorder.
Robert J Berry
The Journal of pediatrics, 163(1), 303-304 (2013-06-26)
Young-Min Kim et al.
Biomaterials, 35(27), 7970-7977 (2014-06-22)
We developed a targetable micelleplex hydrogel as a new efficient systemic siRNA delivery material that functions as a targetable gene carrier, and a hydrogel capable of controlled release to overcome drawbacks of multiple administrations of systemic siRNA carriers due to...
Kenji Kishimoto et al.
Clinical immunology (Orlando, Fla.), 153(1), 17-22 (2014-04-03)
Hereditary folate malabsorption (HFM) is a rare autosomal recessive disorder. Severe folate deficiency in HFM can result in immunodeficiency. We describe a female infant with HFM who acquired severe Pneumocystis pneumonia. The objective of the present study was to elucidate...
Małgorzata Kantorowicz et al.
Przeglad lekarski, 70(1), 28-30 (2013-06-26)
The aim of this paper is to review the available literature pertaining the influence of specific nutritional elements (e.g. vitamin C, vitamin B-complex and dietary calcium) on periodontal status. Effect of food intake on the oral cavity is complex. Proper...
Hideki Mizusako et al.
Journal of pharmaceutical sciences, 104(9), 2934-2940 (2015-05-06)
Active drug targeting is an effective therapeutic approach for the treatment of malignant cancers and novel types of drug carriers have been developed. In this study, we developed a cyclodextrin (CD)-based novel carrier-drug conjugate, called per-FOL-β-CD-ss-DOX, which has folic acid...
Rocío Pérez-Masiá et al.
Food chemistry, 168, 124-133 (2014-08-31)
In this work, two different technologies (electrospraying and nanospray drying) were evaluated for the encapsulation of folic acid using both a whey protein concentrate (WPC) matrix and a commercial resistant starch. The morphology of the capsules, molecular organization of the...
Birgit Hoeft et al.
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition, 82(5), 316-320 (2013-06-26)
The link between a sufficient intake of vitamins and long term health, cognition, healthy development and aging is increasingly supported by experimental animal, human and epidemiology studies. In low income countries billions of people still suffer from the burden of...
Diep Ngoc Thi Pham et al.
The American journal of clinical nutrition, 98(2), 413-422 (2013-06-28)
β,β-Carotene 15,15'-monooxygenase (BCMO1) converts β-carotene to retinaldehyde. Increased β-carotene consumption is linked to antitumor effects. Retinoic acid reduces the invasiveness in cancer, through inhibition of matrix metalloproteinases (MMPs). In our studies of a mouse model that develops intestinal tumors after...
Maternal folic acid supplementation and risk of autism.
Arshya Vahabzadeh et al.
JAMA, 309(21), 2208-2208 (2013-06-06)
A A Toropov et al.
European journal of medicinal chemistry, 43(4), 714-740 (2007-07-17)
Simplified molecular input line entry system (SMILES) has been utilized in constructing quantitative structure-property relationships (QSPR) for octanol/water partition coefficient of vitamins and organic compounds of different classes by optimal descriptors. Statistical characteristics of the best model (vitamins) are the...
Wulf Hildebrandt et al.
The American journal of clinical nutrition, 102(5), 1014-1024 (2015-10-09)
Elevated total plasma homocysteine (tHcy) is considered to be an independent cardiovascular disease risk factor, although tHcy lowering by B-vitamins improves only certain clinical endpoints. N-acetylcysteine (NAC), a thiol-containing antioxidant, acutely lowers tHcy and possibly also blood pressure. However, to...
Kavita Ahuja et al.
Parasitology international, 64(4), 1-5 (2015-01-15)
Leishmania and Leptomonas are protozoan parasites of the family Trypanosomatidae. Leishmania donovani causes the fatal visceral leishmaniasis (VL; kala-azar) in mammals and is transmitted by sand fly vector. Certain VL-cured human populations in India and Sudan develop post kala-azar dermal...
M C F J de Rotte et al.
Arthritis and rheumatism, 65(11), 2803-2813 (2013-10-30)
To investigate whether baseline concentrations of one-carbon metabolism biomarkers are associated with treatment nonresponse and adverse events in rheumatoid arthritis (RA) patients receiving methotrexate (MTX). A prospective derivation cohort (n = 285) and validation cohort (n = 102) of RA...
James R Lattin et al.
Journal of drug targeting, 23(5), 469-479 (2015-02-13)
Vaporizing emulsion droplets may aid in endosomal rupture as a drug delivery route to the cytosol. Upon insonation, emulsion droplets formed from perfluorocarbon liquids may vaporize with sufficient expansion to disrupt liposomal or endosomal membranes. Emulsion droplets of perfluorohexane (PFC6)...
Ling-Wei Chen et al.
The Journal of nutrition, 145(1), 113-120 (2014-12-21)
Maternal folate, vitamin B-12, and vitamin B-6 concentrations during pregnancy have been shown to influence birth outcomes, but the evidence is inconclusive. We aimed to examine the associations of maternal B-vitamin status with gestational age, birth weight, and length in...
Lijiao Ao et al.
Nanoscale, 6(18), 10710-10716 (2014-08-07)
This paper devotes a novel micellar structure for cancer theranostics by incorporating magnetic and therapeutic functionalities into a natural sourced targeting polymer vehicle. Heparin-folic acid micelles taking advantage of both excellent loading capability and cancer targeting ability have been employed...
Devinder Ubhi et al.
Journal of molecular biology, 426(8), 1839-1847 (2014-02-15)
The cobalamin-independent methionine synthase from Candida albicans, known as Met6p, is a 90-kDa enzyme that consists of two (βα)8 barrels. The active site is located between the two domains and has binding sites for a zinc ion and substrates L-homocysteine...
M V Hryhor'ieva
Ukrains'kyi biokhimichnyi zhurnal (1999 ), 85(5), 149-153 (2014-02-01)
The development of new bioactive polymeric materials is very topical. The goal of the present work was to use an optimized reversed-phase HPLC method to determine the release of folic acid (FA) from polyurethane carriers of different structures in vitro....
Diego Moretti et al.
Annals of the New York Academy of Sciences, 1312, 54-65 (2013-12-18)
Several strategies appear suitable to improve iron and zinc bioavailability from fortified maize, and fortification per se will increase the intake of bioavailable iron and zinc. Corn masa flour or whole maize should be fortified with sodium iron ethylenediaminetetraacetate (NaFeEDTA)...
Daniel J Kim et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(27), 15837-15845 (2020-06-24)
Despite broad appreciation of their clinical utility, it has been unclear how vitamin B12 and folic acid (FA) function at the molecular level to directly prevent their hallmark symptoms of deficiency like anemia or birth defects. To this point, B12...
Qiusha Tang et al.
PloS one, 9(9), e106483-e106483 (2014-09-05)
A practical and effective strategy for synthesis of Folate-NIR 797-conjugated Magnetic Albumin Nanospheres (FA-NIR 797-MAN) was developed. For this strategy, Magnetic Albumin Nanospheres (MAN), composed of superparamagnetic iron oxide nanoparticles (SPIONs) and bovine serum albumin (BSA), were covalently conjugated with...
A Gangjee et al.
Current pharmaceutical design, 13(6), 609-639 (2007-03-10)
Opportunistic infections are known to cause morbidity and mortality in immunocompromised individuals. In addition, serious infections due to several parasites are also known to affect the quality and duration of life in normal individuals. The importance of dihydrofolate reductase (DHFR)...
Jacob Joseph et al.
Nutrients, 5(8), 3235-3256 (2013-08-21)
Over the last four decades, abnormalities in the methionine-homocysteine cycle and associated folate metabolism have garnered great interest due to the reported link between hyperhomocysteinemia and human pathology, especially atherothrombotic cardiovascular disease. However, clinical trials of B-vitamin supplementation including high...
Robert J Huber et al.
Biomolecules, 11(3) (2021-04-04)
Neddylation is a post-translational modification that is essential for a variety of cellular processes and is linked to many human diseases including cancer, neurodegeneration, and autoimmune disorders. Neddylation involves the conjugation of the ubiquitin-like modifier neural precursor cell expressed developmentally...
Van-Minh Le et al.
European journal of medicinal chemistry, 92, 882-889 (2015-02-14)
Traditional chemotherapeutic drugs remain the major treatment for advanced colorectal cancer. However, due to the lack of tumor specificity these drug also destroy healthy tissue and organs, which has been the main reason for treatment failure and mortality. Folate-based drug...
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