Polybrene® is a well-known anti-heparin agent. Also known as 1,5-dimethyl-1,5-diazaundecamethylene polymethobromide and hexadimethrine bromide, this positively charged polymer produces non-specific red blood cell agglutination by neutralizing the red blood cell net negative charge.
Chemical ligation strategies are widely utilized for the modification of biological macromolecules in biotechnology and medicine, and in for the development of functional materials. In particular, reagents that can modify the surface of proteins, typically through reactive side chains, have...
Although antibody-drug conjugates show promise in the development of effective cancer therapies, there are still a variety of challenges involved in enabling the safe manufacture of these hazardous drugs.
SAFC’s St. Louis, Missouri (USA) campus is a key center of manufacturing excellence in cGMP biologics, with over 25 years experience in plant- and animal-based therapeutic protein extraction and purification, bio-conjugation, excipients and adjuvants manufacturing.
Originally reported by Staudinger and Meyer, azides react readily with triarylphosphines to form the corresponding iminophophoranes. The Staudinger Ligation: A High-Yield, Chemoselective, and Mild Synthetic Method.
1 Introduction of a guanidinyl group can be achieved by the reaction of substituted amines with various guanylation reagents.2,3,4 One such guanylating reagent is bis(tert-butoxycarbonyl)thiopseudourea, polymer-bound.
The special need of SPPS for rapid and highly efficient coupling reagents led to the development of several new reagents starting from BOP (Benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate).
Based on the same working principle as the nontraceless Staudinger Ligation the auxiliary phosphine reagent can be cleaved from the product after the ligation is completed leaving a native amide bond. Thus, the total chemical synthesis of proteins and glycopeptides...
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