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Poly(Glycerol Sebacate) in Tissue Engineering and Regenerative Medicine
The world of commercial biomaterials has stagnated over the past 30 years as few materials have successfully transitioned from the bench to clinical use. Synthetic aliphatic polyesters have continued to dominate the field of resorbable biomaterials due to their long
Tools for PEGylation
Polyethylene glycol (PEG) reagents offer numerous favorable characteristics, including high water solubility, high mobility in solution, lack of toxicity and immunogenicity, and ready clearance from the body.
Applications of Y-Shape Peg Derivatives for Drug Delivery
The immune system protects the body from disease by resisting the invasion of foreign molecules into its cells, for example peptides and proteins are hydrolyzed by proteolytic enzymes; nucleic acids are hydrolyzed by nucleases; and most small molecules are eliminated
Biodegradable Polyester Based Nanoparticle Formation by Miniemulsion Technique
Aliphatic polyesters such as polylactide, poly(lactide-co-glycolide) and polycaprolactone, as well as their copolymers, represent a diverse family of synthetic biodegradable polymers that have been widely explored for medical uses and are commercially available.
What Are Biomaterials?
Biocompatible / Biodegradable Polymer Tutorial
Critical Micelle Concentrations (CMCs) - Avanti® Polar Lipids
The critical micelle concentration (CMC) can be approximately defined as the lipid monomer concentration at which appreciable amounts (>5% of total) of micellar aggregates first begin to appear in the equilibrium: nM1Mn
Poly(2-oxazoline)s (POx) in Biomedical Applications
Poly(2-oxazoline)s (POx) can be viewed as conformational isomers of polypeptides. They are synthesized via living cationic ringopening polymerization (LCROP) of 2-oxazolines and were almost simultaneously discovered in 1966 by the groups of Litt, Tomalia, Fukui and Seeliger.
Nanoparticle-Based Drug and Gene Delivery for Tumor Targeting
Professor Yoshiki Katayama (Kyushu University, Japan) discusses recent advances in drug delivery systems and strategies that exploit the EPR effect, with a special focus on stimuli-responsive systems based on novel materials.
Layer-by-Layer (LbL) Assembly, A "Gentle Yet Flexible" Method Toward Functional Biomaterials
Recently, layer-by-layer (LbL) assembly has emerged as a versatile, gentle and, simple method for immobilization of functional molecules in an easily controllable thin film morphology.1,2 In this short review, we introduce recent advances in functional systems fabricated by using the
Delivery of Nucleic Acids Using Polymers
Delivery of Nucleic Acids Using Polymers
Electrospun Nanofibers for Drug Delivery Systems
Local delivery of bioactive molecules using an implantable device can decrease the amount of drug dose required as well as non-target site toxicities compared to oral or systemic drug administration.
Degradex® Microspheres and Nanoparticles for Drug Delivery Research and Formulation Development
Study on how Degradex® PLGA microspheres and nanoparticles can be used for drug delivery research and formulation development.
Poly(Amino Acid) Block Copolymers for Drug Delivery and other Biomedical Applications
Humankind has utilized protein materials throughout its existence, starting with the use of materials such as wool and silk for warmth and protection from the elements and continuing with the use of recombinant DNA techniques to synthesize proteins with unique
Halloysite Nanotubes Applications in Nanomaterials Research
Halloysite Nanotubes in Nanomaterials Research. Halloysite, a naturally occurring aluminosilicate nanotube, has been undeservedly forgotten.
Chitosan-based Biomaterials
Chitin, a natural polysaccharide, is the second most abundant natural biopolymer in the world, after cellulose.
Polymersomes for Drug Delivery
The development of drugs that target specific locations within the human body remains one of the greatest challenges in biomedicine today.
Poly(2-Oxazoline)s: The Versatile Polymer Platform for Biomedicine
The introduction of polymers into the biomedical field has opened new avenues in tissue engineering, implant design, biosensing, and drug delivery.
Dendrons and Hyperbranched Polymers: Multifunctional Tools for Materials Chemistry
Dendrons in nanomaterials - Find features and benefits of polyester dendrons and hyperbranched polymer products.
Silica-coated Gold Nanoparticles: Surface Chemistry, Properties, Benefits and Applications
In the past few decades, research and commercial use of gold nanoparticles has rapidly expanded into fields extending from biomedical engineering to photovoltaics. Most applications take advantage of the excellent optical properties of gold nanoparticles, which can be fine-tuned by
Therapeutic Nanoparticles Harness Myeloid Cells for Brain Tumor-Targeted Delivery and Immunomodulation
Immunosuppressive tumor-associated myeloid cells (TAMC) are responsible for glioblastoma (GBM) resistance to immunotherapies and existing standard of care treatments. This mini-review highlights recent progress in implementing nanotechnology in advancing TAMC-targeted therapies for GBM.
Microfluidics for Nanoencapsulation of Nucleic Acids Using Polymeric Carriers
Microfluidic assembly can efficiently overcome the general disadvantages of polyamine nanoencapsulation of nucleic acids, such as a less defined morphology and composition, polydispersity, and poor reproducibility.
NanoFabTx™ Nanoparticle and mRNA Liposome Formulation Using the NanoAssemblr®
NanoFabTX drug delivery formulation kits and lipids mixes for mRNA, nucleic acid, and small molecule delivery in lipid nanoparticles, liposomes and polymeric nanoparticles prepared using Precision NanoSystems microfluidic NanoAssemblr
RESOMER® Biodegradable Polymers for Medical Device Applications Research
Find use of RESOMER® biodegradable polymers in medical device applications research.
Quantum Dots
Quantum dots are tiny particles or nanocrystals of a semiconducting material with diameters in the range of 2-10 nanometers.
Gold Nanoparticles: Properties and Applications
Gold (Au) nanoparticles have tunable optical and electronic properties and are used in a number of applications including photovoltaics, sensors, drug delivery & catalysis.
Functional RAFT Polymers for Biomedical Applications
Reversible addition–fragmentation chain transfer (RAFT) polymerization is rapidly moving to the forefront in construction of drug and gene delivery vehicles.
Injectable Hydrogels for Cell Delivery and Tissue Regeneration
The use of hydrogel-based biomaterials for the delivery and recruitment of cells to promote tissue regeneration in the body is of growing interest. This article discussed the application of hydrogels in cell delivery and tissue regeneration.
Rational Design of ECMs Toward Cancer Immunotherapy
Engineered ECMs enhance immune therapy in cancer treatment by supporting cells and tissues and modulating immune response. They improve immune cell maturation, expansion, and regulation through biomaterial manipulation, acting as frameworks or carriers for enhanced tumor immunotherapy.
Drug Delivery FAQs
Find answers to common questions about drug delivery. Review important points about encapsulation efficiency and loading capacity.
Preparation of Chitosan Microparticles by Spray Drying
Carcinogenic compounds in elastomers: 1,3-butadiene and isoprene used in elastomer manufacturing, classified as carcinogenic by IARC.
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