Liquid Formulation Strategies

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Addressing Viscosity Challenges for Subcutaneous Injections

This overview provides strategies for reducing the viscosity of high concentration drug formulations to enable subcutaneous injections for greater patient convenience and adherence.

Parenteral Drugs: Ensuring Sterility and Minimizing Risks During Manufacturing

Learn strategies to help ensure the sterility of parenteral drugs and minimize risk during manufacturing of these high-risk applications.

Improving API Solubility

This article describes the solubility challenge presented by many small molecule APIs and strategies to overcome these issues during the formulation process.

Arcofolin^® Methylfolate

Arcofolin® Methylfolate as a superior alternative to Folic Acid has uniquely become available for nutritional supplementation and fortification.

Comparison of Preservatives Used in Various Therapeutic Applications

Find key considerations for the selection and use of benzalkonium chloride, benzyl alcohol, benzaldehyde, parabens, benzoic acid, and sodium benzoate as preservatives.

Criteria for Selecting Preservatives Used in Liquid Formulation

Find key considerations for the selection and use of preservatives in a range of different therapeutic applications including topical, oral, transmucosal, inhalation, and otic, as well as injectables.

Overcoming Excipient Risks and Challenges for Parenteral Formulations

This overview describes the challenges when developing parenteral formulations and strategies to overcome them and reduce the risk of production.

Viscosity Reduction in High Concentration TFF

This overview describes how use of viscosity-reducing excipients can address viscosity challenges in high concentration tangential flow filtration (TFF) and improve process economics.

Use of PVA to Overcome Challenges in Ophthalmic Formulations

PVA meets all the essential requirements to be used in ophthalmic preparations and offers important benefits compared to HPMC and CMC.

Facilitate Handling of Bulk Powders with Dry Granulation

Handling bulk powders at a large scale in the pharmaceutical, biopharmaceutical, and bioprocessing setting is challenging. Compared to powders, granulated materials experience far less caking, have better flowability, and are easier to handle, even after long-term storage.

Improving API Solubility using API Processing

Instead of addressing API solubility during formulation, tackle it early during development. Read about the various methods for API processing.