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Organic reaction toolbox

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BASIONICS™, BASF’s Portfolio of Ionic Liquids
Under the trade name BASIONICS™, BASF offers a portfolio of Ionic Liquids—mainly based on imidazolium cations. The BASIONICS™ portfolio opens up a broad range of basic properties of Ionic Liquids and is classified into standard, acidic, basic, liquid at RT
N-Heterocyclic Carbene Ligands
A wide range of NHC ligands are commonly available which exhibit high activities.
Applications for Bis(pyridine)iodonium Tetrafluoroborate
Bis(pyridine)iodonium tetrafluoroborate is a mild iodinating and oxidizing reagent capable of selectively reacting with a wide range of unsaturated substrates and tolerates a variety of functional groups.
Ionic Liquids
Ionic Liquids have experienced a comet-like boost in the last few years. In this edition of ChemFiles, we highlight some current applications of this fascinating class of new materials. We present over 50 new additions to our portfolio of 130+
Organic Azides and Azide Sources
Since the preparation of the first organic azide, phenyl azide, by Peter Griess in 1864 this energy-rich and versatile class of compounds has enjoyed considerable interest.
Dess–Martin Periodinane
Dess-Martin Periodinane is used for the mild oxidation of alcohols to aldehydes and ketones. The neutral condition of the reaction makes DMP suitable for syntheses of sensitive, functionally complex intermediates.
Task-Specific Ionic Liquids
Task-Specific Ionic Liquids (TSILs) for the selective liquid/liquid extraction of heavy metals from aqueous systems were first published by Robin D. Rogers et al. in the year 2001.
Oxidizing and Reducing Agents
Oxidation and reduction reactions are some of the most common transformations encountered in organic synthesis
BINAP/SEGPHOS® Ligands and Complexes
We present an article concerning BINAP/SEGPHOS® Ligands and Complexes.
Imidazolium Derived Reagents
N-Acylimidazoles were recognized in the early 1950s as reactive intermediates suitable for the acylation of amino compounds. The search for better coupling reagents than DCC led to the development of CDI (1,1’-carbonyldiimidazole) and related carbonylimidazoles.
Selecting Orthogonal Building Blocks
Novabiochem® product range has one of the largest collections of orthogonally and quasi-orthogonally protected tri-functional amino acids. These derivatives are useful tools for the synthesis of cyclic and branched peptides and peptides carrying side-chain modifications.
Functionalized Silica Gels for Organic Synthesis
Functionalized silica gel is used in size-exclusion chromatography of cationic polymers and in the separation of sugars, steroids, cholesterol, and triglycerides.
Over the past several years, the Pd-catalyzed cross-coupling of silicon compounds (Hiyama coupling) has rapidly gained acceptance as a suitable alternative to more commonly used methods such as Stille (Sn), Kumada (Mg), Suzuki (B), and Negishi cross-couplings (Zn).
Sure/Seal™ Packaging System
Our Sure/Seal air-sensitive and anhydrous packaging system has been improved to incorporate larger puncture are and new elastomer liner which has greater sealing properties.
Pressure Conversion Table
Pressure conversion table and chart. The pressure converter is ideal for converting atm to pa, bar to psi, kpa to atm, atm to torr and other common units. Quickly convert units of pressure in the lab, classroom or field.
KitAlysis™ High-Throughput Screening Platform
KitAlysis High-Throughput Screening Kits provide solution to efficiently identify or optimize suitable catalytic reaction conditions. Chemist can rapidly run 24 unique micro scale reactions in parallel with tailored conditions.
Knoevenagel Condensation Reaction
Knoevenagel Condensation is an organic reaction named after Emil Knoevenagel. It is a classic C-C bond formation reaction and a modification of the Aldol Condensation.
Biginelli Reaction
The Biginelli Reaction is an acid-catalyzed, three-component reaction between an aldehyde, b-ketoester, and urea that produces tetrahydropyrimidones, which have potential pharmaceutical applications.
Fries Rearrangement
The Fries rearrangement reaction is an organic name reaction which involves the conversion of phenolic esters into hydroxyaryl ketones on heating in the presence of a catalyst. Suitable catalysts for this reaction are Brønsted or Lewis acids such as HF
Protected Carbohydrate Building Blocks for More Efficient Syntheses
Carbohydrates and their biologically active glycoconjugate analogs are emerging as an important class of biomolecules.
BINOL and Derivatives
We present an article concerning BINOL and Derivatives.
Chiral Alcohols
Chiral Alcohols
Ynamides: Versatile and Enabling Building Blocks for Chemical Synthesis
The development of original and versatile reagents in modern organic synthesis is of crucial importance for the design of new chemical transformations that enable the fast and efficient assembly of a variety of complex molecules.
Asymmetric Reduction of Ketones
The enantioselective reduction of ketones to alcohols gives access to a pool of chiral building blocks that can be used for the synthesis of natural products. Adolfsson and co-workers reported a novel class of ligands, based on a pseudo-dipeptide, for
Selective Metalations
Selective Metalations using i-PrMgCl·LiCl and s-BuMgCl·LiCl
Mild Mg – Halogen Exchange
Substantial progress has been made in magnesium–halogen exchange reactions used for the preparation of functionalized Grignard reagents containing sensitive moieties such as ester or cyano groups.
Developed by Professor John Hartwig, pentaphenyl(di-tert-butylphosphino)ferrocene (Q-Phos) has emerged to be a premier ligand in coupling reactions with its remarkably broad utility in a variety of C–N, C–O, and C–C bondforming reactions.
Evans-Type Auxiliaries
The asymmetric aldol reaction mediated by chiral auxiliaries is considered to be one of the most important methods for asymmetric C-C bond formation.
PYBOX Ligand - Large Binding Site & Rigid Scaffold
The PYBOX ligand, consisting of a pyridine ring flanked by two oxazoline groups, was introduced in 1989 by Nishiyama.
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