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Showing 1-27 of 27 results
Selecting Orthogonal Building Blocks
Novabiochem® product range has one of the largest collections of orthogonally and quasi-orthogonally protected tri-functional amino acids. These derivatives are useful tools for the synthesis of cyclic and branched peptides and peptides carrying side-chain modifications.
Peptide-Labeling
The spectral properties of Novabiochem®’s chromogenic and fluorogenic derivatives are invaluable tools for biochemistry, having numerous applications in enzymology, protein chemistry, immunology and histochemistry. Novabiochem® range offers one of the most extensive ranges of labeling reagents for the synthesis of...
Trifunctional Probe Building Blocks
In partnership with Pfizer chemists, we have compiled a collection of trifunctional building blocks to enable development of probes.
Resins for the Synthesis of C-Terminal Modified Peptides
Hydroxymethylbenzoic acid (HMBA) is a useful and versatile benzyl ester derived linker, completely resistant to acids (even to liquid HF) but easily cleavable by a variety of nucleophilic reagents to give access to peptides with diverse C-terminal functionalities.
Boc Resin Cleavage and Deprotection
The most popular reagent for cleavage of peptides from Boc-based resins is anhydrous HF. Of all the cleavage procedures HF appears to be the most versatile and least harmful to a wide variety of peptides synthesized on Boc-based resins.
2-Chlorotrityl Resins Preloaded with N-α-Fmoc-Protected Amino Acids
2-Chlorotrityl Resins Preloaded with N-α-Fmoc-Protected Amino Acids
Coupling Reagents
In principle, the seemingly simple formation of a peptide bond can be accomplished using all the procedures available in organic chemistry for the synthesis of carboxylic acid amides. However, due to the presence of various functional groups in natural and...
Resins for the Fmoc-/tBu-Synthesis of Peptide Acids
The TFA-labile Wang resin is a standard support for batch synthesis of peptide acids following the Fmoc-/tBu-protection scheme.
Acid Halogenation Reagents
The generation of an acid chloride is an obvious way to activate the carboxy group for amide bond formation. However, practical application of acid chlorides in peptide synthesis is restricted, because they are prone to side reactions and racemization.
Methyl Isotope-Labeling of Proteins from NMR-Bio
Methyl groups are ideal probes for studying protein structure and function by NMR. Choose among user-friendly kits for isotope labeling of a single type or multiple types of methyl groups.
Overcoming Aggregation in Solid-phase Peptide Synthesis
Learn how to overcome aggregation in Solid Phase Peptide Synthesis
Fluorescent Labeling of Peptides
Fluorescent Labeling of Peptides
Peptide Coupling Reagents Selection Guide
Novabiochem® offers a large number of coupling reagents for in situ activation. In situ activating reagents are easy to use, fast reacting – even with sterically hindered amino acids, and their use is generally free of side reactions.
Merrifield Peptide Resins
These chloromethylated styrene/divinyl benzene copolymers have been crucial to the development of techniques and technology leading to the routine, convenient synthesis of peptides.
Crystallization
The elucidation of a macromolecular structure to the atomic level by X-ray or neutron diffraction analysis requires the molecule to be available in the form of relatively large single crystals. Many soluble proteins, membrane proteins, nucleic acids and nucleoprotein complexes...
Carbodiimide-mediated peptide coupling
Carbodiimide-mediated peptide coupling remains to the most frequently used technique.
Heterocycle and Cyclic Peptide Formation with N-(isocyamino)triphenylphosphorane (Pinc)
Isocyanides are widely used reagents in organic synthesis, with applications ranging from materials science to drug discovery.
Peptide Modifications: N-Terminal, Internal, and C-Terminal
Peptide Modifications: N-Terminal, Internal, and C-Terminal
Linkers for Fmoc SPPS
Novabiochem® has one of the most extensive ranges of linkers and derivatized resins for Fmoc solid phase peptide synthesis. These resins have varied properties with special protocols for loading and cleaving.
Unnatural Amino Acids
Unnatural amino acids, the non-proteinogenic amino acids that either occur naturally or are chemically synthesized, are becoming more and more important as tools for modern drug discovery research.
Peptide-Labeling
The spectral properties of Novabiochem®’s chromogenic and fluorogenic derivatives are invaluable tools for biochemistry, having numerous applications in enzymology, protein chemistry, immunology and histochemistry. Novabiochem® range offers one of the most extensive ranges of labeling reagents for the synthesis of...
Solving Aspartimide Formation in Fmoc SPPS with Fmoc-Asp(OBno)-OH
Aspartimide formation 1,2 is caused by repeated exposure of aspartic acid-containing sequences to bases like piperidine and can result ultimately in the generation of 9 different by-products.
Chemoselective Purification Tags
Our long peptide purification utilizes a combination of chemoselective purification tags and standard RP-HPLC. The method is especially effective at removing impurities that are closely eluting or hidden under the isolated product peak
Natural Amino Acid Building Blocks for Peptide Synthesis
With a growing peptide drug market the fast, reliable and uncomplicated synthesis of peptides is of paramount importance.
Rink Amide (RAM) Resins
A broad variety of 4-((2,4-dimethoxyphenyl)(Fmoc-amino)methyl)phenoxyalkyl functionalized supports have been developed for the synthesis of peptide carboxamides.
COMU-Safer and More Efficient Peptide Coupling Reagent
COMU is a non-explosive coupling agent suitable for solution phase & solid phase peptide synthesis. Its activity meets or exceeds that of HATU and its water-soluble by-product are easily removed.
Proline Derivatives and Analogs
Proline analogues are promising candidates for tuning the biological, pharmaceutical, or physicochemical properties of naturally occuring, as well as de novo designed, linear, and, cyclic peptides.

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