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Cell Line Development
Our full cell line development capabilities and expertise span from DNA and vector constructs to top clonal selection, research and master cell banks, and stability studies.
Cell Design Studio Quote Request
Request additional information about our cell engineering services
Soaring Savings URZ
soaring savings
Hot Start PCR
The purpose of Hot Start PCR is to inhibit the PCR reaction in order to reduce nonspecific amplification, prevent the formation of primer dimers, and increase product yields.
UAT-Test CSR Links in Static Table Component
DESC: UAT-Test CSR Links in Static Table Component - Version 2
Asia Pacific
Asia Pacific Region
Key Quality Attributes for mRNA Drug Substance Performance - Considerations and Best Practices
With the mRNA platform technology offering unprecedented flexibility, key quality attributes are essential for success of any mRNA based therapeutic. Join us to learn about key quality attributes of mRNA and how our PCR-based manufacturing technology can accelerate mRNA development
Precision Genetic Modifications
Our scientists’ years of experience and Sigma-Aldrich’s access to multiple advanced gene editing technologies allow us to offer a cell engineering service with unparalleled success. We can engineer a variety of modifications in your cell line of choice to address
UAT-Hero-Carousel-Enhancements - AEM2-738
UAT-Hero-Carousel-Enhancements - AEM2-738
Environmental Impacts in Biopharma Single-Use Manufacturing
As biopharma manufacturing moves towards the disposable options, questions arise from all the plastic waste that is generated by using single-use systems. Hear about the environmental benefits as well as emerging recycling technology that may help to reduce the carbon
Virtual Symposium: How mRNA Technology Impacts our Future
In this technical symposium, industry experts will present various aspects of mRNA technology and latest trends in the field.
Hand-casting gels for PAGE and SDS-PAGE using TurboMix® Bis-Tris Gel Casting Kits
Overview of polyacrylamide gel chemistry and detailed instructions for hand-casting polyacrylamide gels using TurboMix® Bis-Tris Gel Casting Kits
World Science Day Drawing
Dynamic Live Cell Imaging of Caspase Mediated Apoptosis and Cellular Hypoxia in Lymphocytes and Cancer Cells Using the CellASIC® ONIX2 Microfluidic Platform
Application note on how the CellASIC® ONIX2 microfluidic system can be used to analyze caspase-3 mediated apoptosis/cell death and cellular hypoxia in live immune and cancer cell lines.
Simplifying CRISPR Licensing
MilliporeSigma has announced a new licensing collaboration with the Broad Institute that can simplify your path to licensing CRISPR technology, while making it more widely available to the global research and discovery community at large.
Introducing the VirusExpress® AAV Production Platform
The VirusExpress® Platform offers a transfection-based solution to Adeno-Associated Viral (AAV) production challenges, featuring a suspension adapted cell line, chemically defined medium, and a clinically relevant process.
CellASIC® ONIX live cell analysis platform for neural stem cell microenvironment control
This article describes CellASIC® ONIX live cell analysis platform for neural stem cell microenvironment control
Tools for PEGylation
Polyethylene glycol (PEG) reagents offer numerous favorable characteristics, including high water solubility, high mobility in solution, lack of toxicity and immunogenicity, and ready clearance from the body.
Applications of Y-Shape Peg Derivatives for Drug Delivery
The immune system protects the body from disease by resisting the invasion of foreign molecules into its cells, for example peptides and proteins are hydrolyzed by proteolytic enzymes; nucleic acids are hydrolyzed by nucleases; and most small molecules are eliminated
Biodegradable Polyester Based Nanoparticle Formation by Miniemulsion Technique
Aliphatic polyesters such as polylactide, poly(lactide-co-glycolide) and polycaprolactone, as well as their copolymers, represent a diverse family of synthetic biodegradable polymers that have been widely explored for medical uses and are commercially available.
Avanti® Polar Lipids: Frequently Asked Questions
Avanti® Polar Lipids: Frequently Asked Questions
What Are Biomaterials?
Biocompatible / Biodegradable Polymer Tutorial
Critical Micelle Concentrations (CMCs) - Avanti® Polar Lipids
The critical micelle concentration (CMC) can be approximately defined as the lipid monomer concentration at which appreciable amounts (>5% of total) of micellar aggregates first begin to appear in the equilibrium: nM1Mn
Poly(2-oxazoline)s (POx) in Biomedical Applications
Poly(2-oxazoline)s (POx) can be viewed as conformational isomers of polypeptides. They are synthesized via living cationic ringopening polymerization (LCROP) of 2-oxazolines and were almost simultaneously discovered in 1966 by the groups of Litt, Tomalia, Fukui and Seeliger.
Nanoparticle-Based Drug and Gene Delivery for Tumor Targeting
Professor Yoshiki Katayama (Kyushu University, Japan) discusses recent advances in drug delivery systems and strategies that exploit the EPR effect, with a special focus on stimuli-responsive systems based on novel materials.
Solvent Challenges Associated Storing and Extraction of Lipids
Dr. Robert Murphy, professor at University of Colorado - Denver, discusses the challenges of solvents associated with the storing and extraction of lipids.
Fabrication of Drug-loaded Microparticles Using Hydrogel Technology and Recent Innovation in Automation
Microparticle drug delivery systems have been extensively researched and applied to a wide variety of pharmaceutical and medical applications due to a number of advantages including injectability, local applicability to target tissues and sites, and controlled drug delivery over a
Use of Iron Oxide Incorporated Conjugated Polymer Nanoparticles for Bioimaging
Our highly fluorescent iron oxide incorporated conjugated polymer nanoparticles (CPNs) have an iron oxide and semiconductor light emitting polymer core, encapsulated within a biocompatible surfactant. The multi-modal particles can be used in both fluorescence and magnetic resonance imaging. Learn more
Layer-by-Layer (LbL) Assembly, A "Gentle Yet Flexible" Method Toward Functional Biomaterials
Recently, layer-by-layer (LbL) assembly has emerged as a versatile, gentle and, simple method for immobilization of functional molecules in an easily controllable thin film morphology.1,2 In this short review, we introduce recent advances in functional systems fabricated by using the
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