Showing 1-30 of 114 results for "

FD4

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Jixiang Zhang et al.
European journal of pharmacology, 873, 172992-172992 (2020-02-09)
Hesperetin, a flavonoid from citrus fruits, possess various pharmacological properties, including anti-inflammatory, anti-oxidative, anti-tumor potentials. However, the role and its mechanism in ulcerative colitis (UC) remains unclear. This study aimed to investigate the protective effects and mechanisms of hesperetin on...
Jianxiang Xue et al.
Clinical science (London, England : 1979), 134(8), 941-953 (2020-04-01)
The sodium-hydrogen exchanger isoform 3 (NHE3, SLC9A3) is abundantly expressed in the gastrointestinal tract and is proposed to play essential roles in Na+ and fluid absorption as well as acid-base homeostasis. Mutations in the SLC9A3 gene can cause congenital sodium...
Manon Defaye et al.
Scientific reports, 10(1), 9146-9146 (2020-06-06)
Infectious gastroenteritis is a risk factor for the development of post-infectious Irritable Bowel Syndrome (PI-IBS). Recent clinical studies reported a higher prevalence of the intestinal parasite Blastocystis in IBS patients. Using a rat model, we investigated the possible association between...
Shouquan Dong et al.
Digestive diseases and sciences, 63(1), 92-104 (2017-09-06)
Tight junction (TJ) injuries induced by pepsin-trypsin-resistant gliadin (PT-G) play an important role in the pathogenesis of celiac disease. Previously, 1,25-dihydroxy vitamin D3 (VD3) was reported to be a TJ regulator that attenuates lipopolysaccharide- and alcohol-induced TJ injuries. However, whether...
Jiangtao Li et al.
BMC nephrology, 20(1), 16-16 (2019-01-13)
Recent researches indicate that the intestinal consequences of renal ischemia reperfusion (IR) would predispose to the translocation of gut-derived endotoxin. Here, we designed experiments to test the hypothesis that the gut-derived endotoxin has a potential role in mediating local inflammatory...
Satoshi Nogami et al.
International journal of pharmaceutics, 592, 120047-120047 (2020-11-11)
Extensive efforts have been directed toward developing novel easily digested formulations with desirable controlled-release properties. The present study sought to develop pH-responsive oral gel formulations using combinations of gelatin and enteric polymers for controlled drug release under stimulated gastric conditions...
Takahiro Nii et al.
The journal of poultry science, 57(2), 148-159 (2020-05-29)
Salmonella Typhimurium (ST) infection in chickens inhibits their growth and can lead to food-borne diseases in humans. Probiotics are expected to enhance the function of host intestinal barrier against pathogen infection. The aim of our study was to determine the...
Gabor Eros et al.
Arthritis research & therapy, 11(2), R43-R43 (2009-03-20)
Phosphatidylcholine and phosphatidylcholine-derived metabolites exhibit anti-inflammatory properties in various stress conditions. We hypothesized that dietary phosphatidylcholine may potentially function as an anti-inflammatory substance and may decrease inflammatory activation in a chronic murine model of rheumatoid arthritis (collagen-induced arthritis). The experiments...
Pratibha Singh et al.
Disease models & mechanisms, 13(8) (2020-08-06)
Prematurity and enteral feedings are major risk factors for intestinal injury leading to necrotizing enterocolitis (NEC). An immature digestive system can lead to maldigestion of macronutrients and increased vulnerability to intestinal injury. The aim of this study was to test...
Edwin De Jong et al.
Journal of controlled release : official journal of the Controlled Release Society, 289, 14-22 (2018-09-24)
The delivery of therapeutics to the brain is greatly hampered by the blood-brain barrier (BBB). The use of nanoparticles that can cross the BBB via the process of receptor-mediated transcytosis at blood-brain barrier endothelial cells seems a promising strategy to...
Mimi Bukeirat et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 36(2), 387-392 (2015-12-15)
The blood-brain barrier is composed of cerebrovascular endothelial cells and tight junctions, and maintaining its integrity is crucial for the homeostasis of the neuronal environment. Recently, we discovered that mitochondria play a critical role in maintaining blood-brain barrier integrity. We...
Lydia C Garas et al.
The British journal of nutrition, 120(10), 1131-1148 (2018-11-08)
Malnutrition remains a leading contributor to the morbidity and mortality of children under the age of 5 years and can weaken the immune system and increase the severity of concurrent infections. Livestock milk with the protective properties of human milk...
R Inacio et al.
Journal of controlled release : official journal of the Controlled Release Society, 226, 66-76 (2016-02-02)
The local application of controlled hypobaric stress represents a novel means to facilitate drug delivery into the skin. The aims of this work were to understand how hypobaric stress modified the properties of the skin and assess if this penetration...
Hans Vergauwen et al.
Journal of animal science and biotechnology, 8, 30-30 (2017-04-14)
In this study the physiological implications of artificial rearing were investigated. Low (LBW) and normal birth weight (NBW) piglets were compared as they might react differently to stressors caused by artificial rearing. In total, 42 pairs of LBW and NBW...
Shanshan Li et al.
Chinese medicine, 16(1), 22-22 (2021-02-18)
Galli gigeriae endothelium corneum (GGEC) has been effectively used for centuries for the treatment of functional dyspepsia (FD) in clinical practice in Asian countries. However, its potential mechanism and chemical composition remains undertermined. In this study, the chemical profile of...
Yosuke Hashimoto et al.
The Journal of pharmacology and experimental therapeutics, 363(2), 275-283 (2017-08-19)
A current bottleneck in the development of central nervous system (CNS) drugs is the lack of drug delivery systems targeting the CNS. The intercellular space between endothelial cells of the blood-brain barrier (BBB) is sealed by complex protein-based structures called...
Maleenart Petchsangsai et al.
Biological & pharmaceutical bulletin, 37(8), 1373-1382 (2014-06-17)
The objective of the present work was to investigate the effects of 3 combinatorial techniques (microneedle (MN), electroporation (EP), and sonophoresis (SN)) on the in vitro skin permeation of the hydrophilic macromolecular compound fluorescein isothiocyanate-dextran (FD-4; molecular weight (MW) 4.4 kDa)....
Sandra Dittmar et al.
Journal of virology, 82(22), 11273-11282 (2008-09-05)
In order to analyze whether measles virus (MV) is transported via transmigrating leukocytes across endothelial barriers or whether virus spreads via infection of endothelial cells and basolateral release, we investigated the migratory behavior of infected human primary T lymphocytes across...
Nathan J Klingensmith et al.
Shock (Augusta, Ga.), 47(2), 184-192 (2016-07-29)
Epidermal growth factor (EGF) is a cytoprotective protein that improves survival in preclinical models of sepsis through its beneficial effects on intestinal integrity. Alcohol use disorder worsens intestinal integrity and is associated with increased morbidity and mortality in critical illness....
Hu Huang et al.
PloS one, 6(6), e21411-e21411 (2011-07-07)
VEGFR1 and 2 signaling have both been increasingly shown to mediate complications of ischemic retinopathies, including retinopathy of prematurity (ROP), age-related macular degeneration (AMD), and diabetic retinopathy (DR). This study evaluates the effects of blocking VEGFR1 and 2 on pathological...
Manuele Gori et al.
Antioxidants (Basel, Switzerland), 9(5) (2020-05-18)
Palmitic acid (PA), a long-chain saturated fatty acid, might activate innate immune cells. PA plays a role in chronic liver disease, diabetes and Crohn's disease, all of which are associated with impaired intestinal permeability. We investigated the effect of PA...
Wenkui Song et al.
Marine drugs, 17(8) (2019-08-03)
The effect of collagen peptides (CPs) in intestinal mucosal protection has been approved in both cell and animal models. However, its structure-activity relationship and efficient peptide sequences are unclear, which hinders the in-depth study of its action mechanism and relative...
Zijuan Zhou et al.
Frontiers in immunology, 8, 1468-1468 (2017-11-28)
Activation of the TNF-α receptor (TNFR) leads to an inflammatory response, and anti-TNF therapy has been administered to reduce inflammation symptoms and heal mucosal ulcers in inflammatory bowel disease (IBD). Bromelain, a complex natural mixture of proteolytic enzymes, has been...
M Boido et al.
Scientific reports, 9(1), 6402-6402 (2019-04-27)
Advanced therapies which combine cells with biomaterial-based carriers are recognized as an emerging and powerful method to treat challenging diseases, such as spinal cord injury (SCI). By enhancing transplanted cell survival and grafting, biomimetic hydrogels can be properly engineered to...
Akie Okada et al.
International journal of pharmaceutics, 577, 118944-118944 (2019-12-25)
Skin offers an easily accessible and convenient site for the administration of drugs. Therefore, the development of injectable formulations with controlled drug release properties are now expected to deliver middle- and large-size biomolecules. In the present study, formulations mainly composed...
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Junjie Liu et al.
Free radical biology & medicine, 147, 90-101 (2019-12-16)
The involvement of reactive oxygen species (ROS) has been suggested in the development of inflammatory bowel disease (IBD). An impaired intestinal barrier function is common in IBD patients. Here, we report the central role of NOX1/NADPH oxidase, a major source...
Palmatine regulates bile acid cycle metabolism and maintains intestinal flora balance to maintain stable intestinal barrier.
Ning, et al.
Life Sciences, 262, 118405-118405 (2020)
Philippe Bercier et al.
Pathogens and disease, 77(1) (2018-11-06)
Actinobacillus pleuropneumoniae is a respiratory pathogen that causes porcine pleuropneumonia, a fatal respiratory disease responsible for high economic losses in the swine industry worldwide. With the objective to better understand the interactions between A. pleuropneumoniae and the porcine respiratory epithelium...
F Ruini et al.
Biomedical materials (Bristol, England), 10(6), 065002-065002 (2015-11-04)
Chitosan (CS), a derivative of the naturally occurring biopolymer chitin, is an attractive material for biomedical applications thanks to its biocompatibility, biodegradability, antibacterial properties and ability to enhance cell adhesion and growth compared to other biopolymers. However, the physical and...