Showing 1-16 of 16 results for "G0407"
L G Schuettpelz et al.
Leukemia, 28(9), 1851-1860 (2014-02-13)
Recent studies demonstrate that inflammatory signals regulate hematopoietic stem cells (HSCs). Granulocyte colony-stimulating factor (G-CSF) is often induced with infection and has a key role in the stress granulopoiesis response. However, its effects on HSCs are less clear. Herein, we...
Rui Zhang et al.
Hematology (Amsterdam, Netherlands), 20(10), 555-560 (2015-06-13)
The treatment for acute myeloid leukemia (AML) remains an important clinical problem. Recently, hematopoietic stem cell therapy provides promising outcomes. In this study we examined the clinical effect of HLA-mismatched hematopoietic stem cell infusion combined with chemotherapy as a postremission...
Jessy Arbez et al.
Cytotherapy, 17(7), 948-955 (2015-03-31)
This study aimed to characterize the immune effectors contained in the grafts from donor mice mobilized by granulocyte colony-stimulating factor (G-CSF) and plerixafor and to evaluate their impact on the development of acute graft-versus-host-disease (aGVHD). Mobilization was done with G-CSF...
Akiko Sugiyama et al.
Chronobiology international, 32(7), 934-941 (2015-07-15)
Circulating hematopoietic stem cells exhibit robust circadian fluctuations, which influence the mobilized cell yield, even during enforced stem cell mobilization. However, alterations in the expression of circadian clock genes during granulocyte colony-stimulating factor (G-CSF)-induced peripheral blood stem cell (PBSC) mobilization...
Paul J Hurd et al.
The Journal of biological chemistry, 284(24), 16575-16583 (2009-04-14)
Numerous post-translational modifications have been identified in histones. Most of these occur within the histone tails, but a few have been identified within the histone core sequences. Histone core post-translational modifications have the potential to directly modulate nucleosome structure and...
Mohsen Esmaili et al.
Molecular biology research communications, 3(2), 141-147 (2014-06-01)
The present study aimed at investigating the beneficial effects of co-administering granulocyte colony-stimulating factor (G-CSF) and stem cell factor (SCF) in a model of chronic liver injury induced by thioacetamide (TAA). Biochemical and histopathology- cal examinations were performed on serum...
Eijiro Honjo et al.
Acta crystallographica. Section F, Structural biology and crystallization communications, 61(Pt 8), 788-790 (2006-03-03)
The granulocyte-colony stimulating factor (GCSF) receptor receives signals for regulating the maturation, proliferation and differentiation of the precursor cells of neutrophilic granulocytes. The signalling complex composed of two GCSFs (GCSF, 19 kDa) and two GCSF receptors (GCSFR, 34 kDa) consisting...
Yukinori Okada et al.
Human molecular genetics, 19(10), 2079-2085 (2010-02-23)
Neutrophils are the most abundant subtype of white blood cells (WBCs). Although the regulation of the numbers of neutrophils would have substantial clinical impacts, the studies on the variations associated with neutrophil count had not been performed further. To investigate...
Antiopi Varelias et al.
Blood, 125(15), 2435-2444 (2015-02-13)
Idiopathic pneumonia syndrome (IPS) is a relatively common, frequently fatal clinical entity, characterized by noninfectious acute lung inflammation following allogeneic stem cell transplantation (SCT), the mechanisms of which are unclear. In this study, we demonstrate that immune suppression with cyclosporin...
Eleftheria Tsolaki et al.
Blood cells, molecules & diseases, 53(3), 124-132 (2014-06-14)
Bone marrow (BM) could serve as a source of cells facilitating liver repopulation in case of hepatic damage. Currently available hematopoietic stem cell (HSC) mobilizing agents, were comparatively tested for healing potential in liver fibrosis. Carbon tetrachloride (CCl4)-injured mice previously...
The clonogenic potential of selected CD34+ cells from patients with MDS appear preserved when tested ex vivo
Davison GM, et al.
Leukemia Research, 35, 1200-1204 (2011)
Yaron Vagima et al.
PLoS pathogens, 11(5), e1004893-e1004893 (2015-05-15)
Pneumonic plague is a fatal disease caused by Yersinia pestis that is associated with a delayed immune response in the lungs. Because neutrophils are the first immune cells recruited to sites of infection, we investigated the mechanisms responsible for their...
Gerald Wirnsberger et al.
Nature genetics, 46(9), 1028-1033 (2014-08-19)
Neutrophils are key innate immune effector cells that are essential to fighting bacterial and fungal pathogens. Here we report that mice carrying a hematopoietic lineage-specific deletion of Jagn1 (encoding Jagunal homolog 1) cannot mount an efficient neutrophil-dependent immune response to...
Evert-Jan F M de Kruijf et al.
International journal of hematology, 99(6), 714-720 (2014-04-23)
Granulocyte-colony-stimulating factor (G-CSF)-induced hematopoietic stem and progenitor cell (HSPC) mobilization is associated with the release of neutrophil-derived proteases. Previously, we have shown that alpha-1-antitrypsin (AAT) inhibits these proteases in mice, resulting in inhibition of HSPC mobilization. Here, we studied the...
Saurabh Agarwal et al.
Cancer research, 75(12), 2566-2579 (2015-04-25)
Increasing evidence suggests that inflammatory cytokines play a critical role in tumor initiation and progression. A cancer stem cell (CSC)-like subpopulation in neuroblastoma is known to be marked by expression of the G-CSF receptor (G-CSFR). Here, we report on the...
Maria Samalidou et al.
Experimental biology and medicine (Maywood, N.J.), 240(12), 1728-1734 (2015-06-17)
Liposomal amphotericin B, voriconazole, and caspofungin are currently used for systemic and severe fungal infections. Patients with malignant diseases are treated with granulocyte-colony stimulating factor (G-CSF) for the recovery of granulocytes after chemotherapy or hematopoietic cell (HC) transplantation. Since they...

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