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G0885

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Mehdi Rahimpour et al.
The Biochemical journal, 452(3), 559-573 (2013-03-30)
Escherichia coli glycogen metabolism involves the regulation of glgBXCAP operon expression and allosteric control of the GlgC [ADPG (ADP-glucose) pyrophosphorylase]-mediated catalysis of ATP and G1P (glucose-1-phosphate) to ADPG linked to glycogen biosynthesis. E. coli glycogen metabolism is also affected by glgS....
Valentina Gburcik et al.
American journal of physiology. Endocrinology and metabolism, 304(8), E885-E894 (2013-03-14)
Failure of white adipose tissue to appropriately store excess metabolic substrate seems to underpin obesity-associated type 2 diabetes. Encouraging "browning" of white adipose has been suggested as a therapeutic strategy to help dispose of excess stored lipid and ameliorate the...
Joachim Nielsen et al.
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 38(2), 91-99 (2013-02-27)
Glucose is stored in skeletal muscle fibers as glycogen, a branched-chain polymer observed in electron microscopy images as roughly spherical particles (known as β-particles of 10-45 nm in diameter), which are distributed in distinct localizations within the myofibers and are...
Thiago De Souza Candido et al.
The Biochemical journal, 464(3), 323-334 (2014-09-26)
Glycogen functions as a carbohydrate reserve in a variety of organisms and its metabolism is highly regulated. The activities of glycogen synthase and glycogen phosphorylase, the rate-limiting enzymes of the synthesis and degradation processes, respectively, are regulated by allosteric modulation...
Jiaojiao Chu et al.
PloS one, 8(2), e57231-e57231 (2013-02-26)
Apelin, a novel adipokine, is the specific endogenous ligand of G protein-coupled receptor APJ. Consistent with its putative role as an adipokine, apelin has been linked to states of insulin resistance. However, the function of apelin in hepatic insulin resistance...
Xianguo Jiang et al.
Biochemical pharmacology, 177, 114035-114035 (2020-05-16)
Noradrenaline (NA) promotes breakdown of the glucose-polymer, glycogen, and hence enhances glycolytic production of lactate in astrocytes. Here, in cultured rat cerebrocortical astrocytes, we examined the contributions of different adrenoceptor subtypes to NA-modulated glucose metabolism, and the relationship of NA-induced...
Dang Hai Dang Nguyen et al.
Journal of bacteriology, 196(11), 1941-1949 (2014-03-13)
We studied the activity of a debranching enzyme (TreX) from Sulfolobus solfataricus on glycogen-mimic substrates, branched maltotetraosyl-β-cyclodextrin (Glc₄-β-CD), and natural glycogen to better understand substrate transglycosylation and the effect thereof on glycogen debranching in microorganisms. The validation test of Glc₄-β-CD...
Francis B Stephens et al.
Clinical science (London, England : 1979), 127(5), 315-322 (2014-03-13)
Acylcarnitine accumulation in skeletal muscle and plasma has been observed in numerous models of mitochondrial lipid overload and insulin resistance. Fish oil n3PUFA (omega-3 polyunsaturated fatty acids) are thought to protect against lipid-induced insulin resistance. The present study tested the...
Timothy J Sullivan et al.
Metabolism: clinical and experimental, 62(11), 1623-1632 (2013-08-21)
CCR2 inhibition has produced promising experimental and clinical anti-hyperglycemic effects. These results support the thesis that insulin resistance and Type 2 diabetes (T2D) are associated with chronic unresolved inflammation. The aim of this study was to provide a broad analysis...
Bridget E Lester et al.
Aviation, space, and environmental medicine, 84(8), 789-796 (2013-08-10)
Studies of real and simulated microgravity exposure show the lower limb muscles atrophy to the greatest extent, with the calf muscles being most affected and most difficult to target with exercise countermeasures. This ground-based study examined the metabolic involvement of...
Na Zhao et al.
Molecular biology reports, 41(1), 9-18 (2013-12-11)
Glycogen serves as a metabolic reserve and is involved in macromolecular synthesis. Glycogen phosphorylase (GPase) is a key enzyme involved in intracellular glycogen catabolism, catalyzing the first step in glycogen degradation. In the diapause, GPase catalyzes glycogen into the closely...
Qi Zhang et al.
Journal of chromatography. A, 1306, 97-103 (2013-08-06)
In this paper, two novel amino acid chiral ILs, tetramethylammonium-l-arginine (TMA-l-Arg) and tetramethylammonium-l-aspartic acid (TMA-l-Asp), were applied for the first time in CE enantioseparation to evaluate their potential synergistic effect with glycogen as chiral selector. As observed, significantly improved separation...
Amir Tirosh et al.
Science translational medicine, 11(489) (2019-04-26)
The short-chain fatty acid propionate is a potent inhibitor of molds that is widely used as a food preservative and endogenously produced by gut microbiota. Although generally recognized as safe by the U.S. Food and Drug Administration, the metabolic effects...
Lilijana Bizjak Mali et al.
Journal of morphology, 274(8), 887-900 (2013-04-30)
The morphological alterations of hepatocytes of cave-dwelling salamander Proteus anguinus anguinus after food deprivation periods of one and 18 months were investigated and the concentrations of glycogen, lipids, and proteins in the liver were determined. Quantitative analyses of the hepatocyte...
Hyo-Jin Jeong et al.
Biochemical and biophysical research communications, 434(3), 503-508 (2013-04-16)
MicroRNA (miRNA) is a class of endogenous small noncoding RNA that negatively regulates gene expression at the post-transcriptional level and plays an important role in the pathogenesis of various diseases. However, the identity and role of miRNAs involved in the...
Benjamin L Farah et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 28(5), 2272-2280 (2014-01-23)
Enzyme or gene replacement therapy with acid α-glucosidase (GAA) has achieved only partial efficacy in Pompe disease. We evaluated the effect of adjunctive clenbuterol treatment on cation-independent mannose-6-phosphate receptor (CI-MPR)-mediated uptake and intracellular trafficking of GAA during muscle-specific GAA expression...
Malgorzata Gasperowicz et al.
Developmental biology, 382(1), 1-14 (2013-08-21)
TLE3 is a transcriptional co-repressor that interacts with several DNA-binding repressors, including downstream effectors of the Notch signaling pathway. We generated Tle3-deficient mice and found that they die in utero and their death is associated with abnormal development of the...
E Fitzpatrick et al.
Archives of disease in childhood, 99(4), 354-357 (2014-01-15)
Mauriac syndrome is characterised by growth failure, cushingoid appearance and hepatomegaly which occurs in patients with insulin dependent diabetes and was first described shortly after the introduction of insulin as a treatment for the condition. To describe the clinical features...
Robyn G Lottes et al.
American journal of physiology. Lung cellular and molecular physiology, 306(10), L947-L955 (2014-04-01)
Although many lung diseases are associated with hypoxia, alveolar type II epithelial (ATII) cell impairment, and pulmonary surfactant dysfunction, the effects of O(2) limitation on metabolic pathways necessary to maintain cellular energy in ATII cells have not been studied extensively....
Fiore Manganelli et al.
Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology, 32(2), 82-84 (2014-01-09)
Glycogen storage disease type II - also called Pompe disease or acid maltase deficiency - is an autosomal recessive metabolic disorder, caused by an accumulation of glycogen in the lysosome due to deficiency of the lysosomal acid alpha-glucosidase enzyme. Pompe...
Angelika Hartung et al.
Biochimica et biophysica acta, 1833(12), 2803-2811 (2013-07-28)
Akt kinases are important mediators of the insulin signal, and some Akt substrates are directly involved in glucose homeostasis. Recently, Girdin has been described as an Akt substrate that is expressed ubiquitously in mammals. Cells overexpressing Girdin show an enhanced...
A A Zhidenko et al.
Ukrains'kyi biokhimichnyi zhurnal (1999 ), 85(3), 22-30 (2013-08-14)
The use of glyphosate as a herbicide in agriculture can lead to the presence of its residues and metabolites (aminomethylphosphonic acid) in food for human consumption and pose a threat to health. The effect of these herbicides on the fish...
Rathishri Chandurvelan et al.
Aquatic toxicology (Amsterdam, Netherlands), 140-141, 303-313 (2013-07-24)
The biochemical responses of the green-lipped mussel, Perna canaliculus, to waterborne cadmium (Cd) were investigated in order to delineate toxic mechanisms, and the impacts of exposure dose and duration, of this important toxicant in a potential sentinel species. Mussels were...
Lisa C Heather et al.
Circulation. Heart failure, 6(5), 1058-1066 (2013-08-14)
Fatty acid and glucose transporters translocate between the sarcolemma and intracellular compartments to regulate substrate metabolism acutely. We hypothesised that during ischemia fatty acid translocase (FAT/CD36) would translocate away from the sarcolemma to limit fatty acid uptake when fatty acid...
Massimiliano Filosto et al.
Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology, 32(2), 91-94 (2014-01-09)
Glycogenosis II (GSD II) is an autosomal recessive lysosomal storage disorder resulting from acid alpha-glucosidase deficiency, subsequent accumulation of glycogen in tissues, impairment of autophagic processes and progressive cardiac, motor and respiratory failure. The late-onset form is characterized by wide...
Ahmed Th A Ibrahim et al.
Ecotoxicology and environmental safety, 106, 33-39 (2014-05-20)
The present study examined the impacts of carbofuran on endocrinology of the catfish, Clarias gariepinus, for the first time and evaluated cortisol (CRT), triiodothyronine (T3), thyroxin (T4), 17β-estradiol (E2) and testosterone (TST) and the oxidative stress markers including SOD, CAT...
Daniela P Mesquita et al.
Analytica chimica acta, 770, 36-44 (2013-03-19)
The present study focuses on predicting the concentration of intracellular storage polymers in enhanced biological phosphorus removal (EBPR) systems. For that purpose, quantitative image analysis techniques were developed for determining the intracellular concentrations of PHA (PHB and PHV) with Nile...
Juan M Pascual et al.
JAMA neurology, 70(6), 756-763 (2013-04-24)
The physiological relevance of acid maltase (acid α-glucosidase, an enzyme that degrades lysosomal glycogen) is well recognized in liver and muscle. In late (adult)-onset acid maltase deficiency (glycogen storage disease type II [GSD II]), glycogen accumulates inside muscular lysosomes in...
Gregory J Daggett et al.
Journal of medical primatology, 46(5), 232-238 (2017-05-11)
Rhesus and cynomologus macaques are valuable animal models for the study of human immunodeficiency virus (HIV) prevention strategies. However, for such studies focused on the vaginal route of infection, differences in vaginal environment may have deterministic impact on the outcome of...
Neeraj Verma et al.
Indian journal of experimental biology, 51(1), 65-72 (2013-02-28)
Antihyperglycemic potential of hyperin at 25 and 50 mg/kg doses for 30 days to streptozotocin induced diabetic rats has been reported. In oral glucose tolerance test, hyperin treated rats showed a significant reduction in blood glucose level after 120 min....
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