Showing 1-14 of 14 results for "G1401"
Clive Bate et al.
Molecular neurodegeneration, 3, 1-1 (2008-01-09)
The early stages of Alzheimer's disease (AD) are closely associated with the production of the Abeta1-42 peptide, loss of synapses and gradual cognitive decline. Since some epidemiological studies showed that EGb 761, an extract from the leaves of the Ginkgo...
Gunnar H D Poplawski et al.
Nature, 581(7806), 77-82 (2020-05-08)
Grafts of spinal-cord-derived neural progenitor cells (NPCs) enable the robust regeneration of corticospinal axons and restore forelimb function after spinal cord injury1; however, the molecular mechanisms that underlie this regeneration are unknown. Here we perform translational profiling specifically of corticospinal...
Daisuke Shimojo et al.
Molecular brain, 8(1), 79-79 (2015-12-03)
Human pluripotent stem cells (hPSCs) are being applied in regenerative medicine and for the in vitro modeling of human intractable disorders. In particular, neural cells derived from disease-specific human induced pluripotent stem cells (hiPSCs) established from patients with neurological disorders...
Weidong Xiao et al.
Molecular neurobiology, 50(2), 274-289 (2014-06-01)
Acute intestinal ischemia reperfusion (IR) injury is often associated with intestinal epithelial barrier (IEB) dysfunction. Enteric glial cells (EGCs) play an essential role in maintaining the integrity of IEB functions. However, the precise mechanism of EGCs under IR stimulation remains...
Oswald Steward et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(42), 14013-14021 (2014-10-17)
We reported previously the formation of ectopic colonies in widespread areas of the nervous system after transplantation of fetal neural stem cells (NSCs) into spinal cord transection sites. Here, we characterize the incidence, distribution, and cellular composition of the colonies....
Nadezda Kust et al.
Molecular neurobiology, 51(3), 1195-1205 (2014-07-06)
Plasmids containing four GFP-tagged isoforms of the human GDNF gene, with both pre- and pro-regions (pre-pro- GDNF), with the pre- (pre-GDNF) or the pro-region (pro-GDNF) alone, and without the pre- and pro-regions (mGDNF), were used to transfect HEK293 cells (human...
Marie-Josée Beaudet et al.
Scientific reports, 5, 16763-16763 (2015-11-19)
Extraction of mouse spinal motor neurons from transgenic mouse embryos recapitulating some aspects of neurodegenerative diseases like amyotrophic lateral sclerosis has met with limited success. Furthermore, extraction and long-term culture of adult mouse spinal motor neurons and glia remain also...
Roche C de Guzman et al.
Journal of microencapsulation, 25(7), 487-498 (2009-02-25)
Controlled expression of glial cell line derived neurotrophic factor (Gdnf) can be integrated in the development of a system for repair of injured peripheral nerves. This delivery strategy was demonstrated via inducible Gdnf from microencapsulated cells in barium alginate. The...
Kelli G Sharp et al.
Experimental neurology, 257, 186-204 (2014-04-22)
As part of the NIH "Facilities of Research Excellence-Spinal Cord Injury" project to support independent replication, we repeated key parts of a study reporting robust engraftment of neural stem cells (NSCs) treated with growth factors after complete spinal cord transection...
Michela Morano et al.
International journal of nanomedicine, 9, 5289-5306 (2014-12-09)
Innovative nerve conduits for peripheral nerve reconstruction are needed in order to specifically support peripheral nerve regeneration (PNR) whenever nerve autotransplantation is not an option. Specific support of PNR could be achieved by neurotrophic factor delivery within the nerve conduits...
Hyun-Jung Park et al.
Molecular endocrinology (Baltimore, Md.), 29(2), 289-306 (2014-12-31)
Glial cell line-derived neurotrophic factor (GDNF) is a TGFβ family member, and GDNF signals through a glycosyl-phosphatidylinositol-linked cell surface receptor (GFRα1) and RET receptor tyrosine kinase. GDNF signaling plays crucial roles in urogenital processes, ranging from cell fate decisions in...
Brian V Lien et al.
Experimental neurology, 314, 46-57 (2019-01-18)
Neural stem cells (NSCs) can differentiate into both neurons and glia after transplantation into spinal cord injury (SCI) sites. The neuronal component of stem cell grafts has the potential to form functional synaptic relays across the lesion site. The glial...
Heidi de Wet et al.
The Journal of physiology, 590(20), 5025-5036 (2012-07-18)
The sulphonylurea receptor (SUR1) subunit of the ATP-sensitive potassium (KATP) channel is a member of the ATP-binding cassette (ABC) protein family. Binding of MgADP to nucleotide-binding domain 2 (NBD2) is critical for channel activation.We identified a residue in NBD2 (G1401)...
P R Cunningham et al.
Biochemistry, 32(28), 7172-7180 (1993-07-20)
The existence and functional importance of the tertiary base pair G1401:C1501, which brings together two universally present and highly sequence-conserved single-stranded segments of small subunit ribosomal RNA, was proven recently by mutational analysis [Cunningham, P. R., Nurse, K., Bakin, A....

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