Showing 1-26 of 26 results for "G1777"
William A Lackington et al.
Journal of controlled release : official journal of the Controlled Release Society, 304, 51-64 (2019-05-06)
Neurotrophic factor delivery via biodegradable nerve guidance conduits may serve as a promising treatment for the repair of large peripheral nerve defects. However, a platform for controlled delivery is required because of their short in vivo half-life and their potential...
Nadezda Kust et al.
Molecular neurobiology, 51(3), 1195-1205 (2014-07-06)
Plasmids containing four GFP-tagged isoforms of the human GDNF gene, with both pre- and pro-regions (pre-pro- GDNF), with the pre- (pre-GDNF) or the pro-region (pro-GDNF) alone, and without the pre- and pro-regions (mGDNF), were used to transfect HEK293 cells (human...
Generation of Mouse Spermatogonial Stem-Cell-Colonies in A Non-Adherent Culture
Azizi H, et al.
Cell Journal, 19(2), 238-238 (2017)
Marie-Josée Beaudet et al.
Scientific reports, 5, 16763-16763 (2015-11-19)
Extraction of mouse spinal motor neurons from transgenic mouse embryos recapitulating some aspects of neurodegenerative diseases like amyotrophic lateral sclerosis has met with limited success. Furthermore, extraction and long-term culture of adult mouse spinal motor neurons and glia remain also...
Gain at chromosomal region 5p15. 33, containing TERT, is the most frequent genetic event in early stages of non-small cell lung cancer
Kang JU, et al.
Cancer Genetics and Cytogenetics, 182(1), 1-11 (2008)
Nuno Jorge Lamas et al.
PloS one, 9(10), e110324-e110324 (2014-10-23)
Human motor neurons derived from embryonic and induced pluripotent stem cells (hESCs and hiPSCs) are a potentially important tool for studying motor neuron survival and pathological cell death. However, their basic survival requirements remain poorly characterized. Here, we sought to...
Michela Morano et al.
International journal of nanomedicine, 9, 5289-5306 (2014-12-09)
Innovative nerve conduits for peripheral nerve reconstruction are needed in order to specifically support peripheral nerve regeneration (PNR) whenever nerve autotransplantation is not an option. Specific support of PNR could be achieved by neurotrophic factor delivery within the nerve conduits...
Hyun-Jung Park et al.
Molecular endocrinology (Baltimore, Md.), 29(2), 289-306 (2014-12-31)
Glial cell line-derived neurotrophic factor (GDNF) is a TGFβ family member, and GDNF signals through a glycosyl-phosphatidylinositol-linked cell surface receptor (GFRα1) and RET receptor tyrosine kinase. GDNF signaling plays crucial roles in urogenital processes, ranging from cell fate decisions in...
Nicole Parker et al.
Biology of reproduction, 91(4), 92-92 (2014-08-29)
Spermatogonial stem cells (SSCs) are the foundation of spermatogenesis. These cells are classically defined as a subset of morphologically defined A single (As) spermatogonia, which can produce more SSCs or they can give rise to nonstem As cells that, upon...
GDNF gene is associated with tourette syndrome in a family study
Huertas-Fernandez I, et al.
Movement Disorders, 30(8), 1115-1120 (2015)
G Liu et al.
Molecular neurobiology, 50(2), 673-684 (2014-03-29)
There are currently no known treatment options that actually halt or permanently reverse the pathology evident in any neurodegenerative condition. Arguably, one of the most promising avenues for creating viable neuronal treatments could involve the combined use of cell replacement...
Ali Fathi et al.
Molecular biotechnology, 57(2), 184-194 (2014-11-09)
Direct differentiation of dopaminergic (DA) neurons from human pluripotent stem cells (hPSCs) in the absence of gene manipulation is the most desired alternative to clinical treatment of Parkinson disease. Protein transduction-based methods could be efficient, safe approaches to enhance direct...
David D R Sebinger et al.
PloS one, 5(5), e10550-e10550 (2010-05-19)
Here, we present a novel method for culturing kidneys in low volumes of medium that offers more organotypic development compared to conventional methods. Organ culture is a powerful technique for studying renal development. It recapitulates many aspects of early development...
Michael Meir et al.
American journal of physiology. Gastrointestinal and liver physiology, 309(8), G613-G624 (2015-08-22)
Recent data suggest that neurotrophic factors from the enteric nervous system are involved in intestinal epithelial barrier regulation. In this context the glial cell line-derived neurotrophic factor (GDNF) was shown to affect gut barrier properties in vivo directly or indirectly...
Vladimir S Naumenko et al.
Behavioural brain research, 274, 1-9 (2014-08-08)
The effect of glial cell line-derived neurotrophic factor (GDNF) on behavior and brain dopamine system in predisposed to depressive-like behavior ASC (Antidepressant Sensitive Cataleptics) mice in comparison with the parental "nondepressive" CBA mice was studied. In 7days after administration (800ng...
A K Krug et al.
Cell death & disease, 5, e1222-e1222 (2014-05-09)
Assessment of the network of toxicity pathways by Omics technologies and bioinformatic data processing paves the road toward a new toxicology for the twenty-first century. Especially, the upstream network of responses, taking place in toxicant-treated cells before a point of...
Ayob Jabari et al.
Acta histochemica, 122(5), 151572-151572 (2020-07-06)
Application of a three-dimensional (3D) culture system for in vitro proliferation and differentiation of human spermatogonial stem cells (SSCs) is a useful tool for the investigation of the spermatogenesis process and the management of male infertility particularly in prepubertal cancer...
Clive Bate et al.
Molecular neurodegeneration, 3, 1-1 (2008-01-09)
The early stages of Alzheimer's disease (AD) are closely associated with the production of the Abeta1-42 peptide, loss of synapses and gradual cognitive decline. Since some epidemiological studies showed that EGb 761, an extract from the leaves of the Ginkgo...
Daisuke Shimojo et al.
Molecular brain, 8(1), 79-79 (2015-12-03)
Human pluripotent stem cells (hPSCs) are being applied in regenerative medicine and for the in vitro modeling of human intractable disorders. In particular, neural cells derived from disease-specific human induced pluripotent stem cells (hiPSCs) established from patients with neurological disorders...
Maryam Hatami et al.
Cytotherapy, 11(5), 618-630 (2009-06-24)
Several studies have reported functional improvement after transplantation of in vivo-derived neural progenitor cells (NPC) into injured spinal cord. However, the potential of human embryonic stem cell-derived NPC (hESC-NPC) as a tool for cell replacement of spinal cord injury (SCI)...
Jacob L Roam et al.
Biomaterials, 35(24), 6473-6481 (2014-05-13)
Introduction of spatial patterning of proteins, while retaining activity and releasability, is critical for the field of regenerative medicine. Reversible binding to heparin, which many biological molecules exhibit, is one potential pathway to achieve this goal. We have covalently bound...
Matthias K Weng et al.
PloS one, 9(7), e102035-e102035 (2014-07-24)
Despite an abundance of studies on chromatin states and dynamics, there is an astonishing dearth of information on the expression of genes responsible for regulating histone and DNA modifications. We used here a set of 156 defined epigenetic modifier genes...
Novel functions and signalling pathways for GDNF
Sariola H and Saarma M
Journal of Cell Science, 116(19), 3855-3862 (2003)
Roland M Huber et al.
Oncotarget, 6(4), 2134-2147 (2015-01-13)
Though metastatic cancers often initially respond to genotoxic therapeutics, acquired resistance is common. In addition to cytotoxic effects on tumor cells, DNA damaging agents such as ionizing radiation and chemotherapy induce injury in benign cells of the tumor microenvironment resulting...
Chongyang Han et al.
Journal of neurophysiology, 113(9), 3172-3185 (2015-03-20)
Although species-specific differences in ion channel properties are well-documented, little has been known about the properties of the human Nav1.8 channel, an important contributor to pain signaling. Here we show, using techniques that include voltage clamp, current clamp, and dynamic...
Man Zhang et al.
Scientific reports, 4, 5936-5936 (2014-08-05)
C-kit positive (c-kit(+)) cells are usual tissue-specific stem cells. However, in postnatal testis, undifferentiated spermatogonial stem cells (SSCs) are c-kit negative (c-kit(-)) and activation of c-kit represents the start of SSC differentiation, leaving an intriguing question whether other c-kit(+) cells...

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