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Fiona Jasson et al.
Experimental dermatology, 22(9), 587-592 (2013-08-21)
Acne is a chronic inflammatory illness of the pilosebaceous follicle where innate immunity plays a central role. In acne, the density of Propionibacterium acnes is increased in the pilosebaceous unit. We hypothesized that the severity of acne is not only
Jeffrey E Nowak et al.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 13(5), e323-e329 (2012-07-05)
We previously demonstrated that altered zinc homeostasis is an important feature of pediatric sepsis, thus raising the possibility of zinc supplementation as a therapeutic strategy in sepsis. Herein, we tested the hypothesis that prophylactic zinc supplementation would be beneficial in
Mallory L Hammock et al.
Advanced materials (Deerfield Beach, Fla.), 26(35), 6138-6144 (2014-07-23)
Organic field-effect transistor (OFET) sensors can meet the need for portable and real-time diagnostics. An electronicreadout enzyme-linked immunosorbent assay using OFETs for the detection of a panel of three biomarkers in complex media to create a pre-eclampsia prognostic is demonstrated
Sheba Khan et al.
PloS one, 15(8), e0238252-e0238252 (2020-08-29)
We report on aerobic "environmental" bacteria isolated from European honey bees (Apis mellifera). We determined the number of culturable aerobic bacteria in the gut of nurse bees sampled from locations around Australia. Bees from healthy colonies had 107-108 aerobic bacteria
Bjarke Follin et al.
Cytotherapy, 17(8), 1104-1118 (2015-06-03)
Clinical trials have documented beneficial effects of mesenchymal stromal cells from bone marrow and adipose tissue (ASCs) as treatment in patients with ischemic heart disease. However, retention of transplanted cells is poor. One potential way to increase cell retention is
Michael T Rose et al.
Planta, 236(4), 959-973 (2012-04-25)
Plants are routinely subjected to multiple environmental stresses that constrain growth. Zinc (Zn) deficiency and high bicarbonate are two examples that co-occur in many soils used for rice production. Here, the utility of metabolomics in diagnosing the effect of each
Anjana Gulani et al.
The Cochrane database of systematic reviews, 4(4), CD006639-CD006639 (2012-04-20)
Otitis media (OM) is inflammation of the middle ear and is usually caused by infection. It affects people of all ages but is particularly common in young children. Around 164 million people worldwide have long-term hearing loss caused by this
Lei Yang et al.
AMB Express, 4, 54-54 (2014-11-18)
Aspergillus carbonarius has potential as a cell factory for the production of different organic acids. At pH 5.5, A.carbonarius accumulates high amounts of gluconic acid when it grows on glucose based medium whereas at low pH, it produces citric acid.
Matt Hrapchak et al.
Journal of labelled compounds & radiopharmaceuticals, 57(12), 687-694 (2014-10-22)
Empagliflozin, (2S,3R,4R,5S,6R)-2-[4-chloro-3-[[4-[(3S)-oxolan-3-yl]oxyphenyl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol was recently approved by the FDA for the treatment of chronic type 2 diabetes mellitus. Herein, we report the synthesis of carbon-13 and carbon-14 labeled empagliflozin. Carbon-13 labeled empagliflozin was prepared in five steps and in 34% overall
Sandeep Deshmukh et al.
Journal of chromatography. A, 1388, 1-8 (2015-03-01)
Accurate quantitation of compounds in samples of biological origin is often hampered by matrix interferences one of which occurs in GC-MS analysis from the presence of highly abundant phosphate. Consequently, high concentrations of phosphate need to be removed before sample
Chang-Moon Lee et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 54(11), 1974-1980 (2013-09-21)
A new approach to the surface engineering of superparamagnetic iron oxide nanoparticles (SPIONs) may encourage their development for clinical use. In this study, we demonstrated that nonpolymeric surface modification of SPIONs has the potential to be an advanced biocompatible contrast
Johnnie M Moore-Dotson et al.
Journal of neurophysiology, 113(7), 2078-2090 (2015-01-09)
Neurotransmitter release varies between neurons due to differences in presynaptic mechanisms such as Ca(2+) sensitivity and timing. Retinal rod bipolar cells respond to brief dim illumination with prolonged glutamate release that is tuned by the differential release of GABA and
Wilvis Balcazar et al.
Microbiological research, 177, 1-7 (2015-07-28)
Glaciers harbor a wide diversity of microorganisms, metabolically versatile, highly tolerant to multiple environmental stresses and potentially useful for biotechnological purposes. Among these, we hypothesized the presence of bacteria able to exhibit well-known plant growth promoting traits (PGP). These kinds
Ajar Nath Yadav et al.
Scientific reports, 5, 12293-12293 (2015-07-29)
Archaea are unique microorganisms that are present in ecological niches of high temperature, pH and salinity. A total of 157 archaea were obtained from thirteen sediment, water and rhizospheric soil samples collected from Rann of Kutch, Gujarat, India. With an
Óttar Rolfsson et al.
The Biochemical journal, 449(2), 427-435 (2012-10-17)
Metabolic network reconstructions define metabolic information within a target organism and can therefore be used to address incomplete metabolic information. In the present study we used a computational approach to identify human metabolites whose metabolism is incomplete on the basis
L Rajendran et al.
The Journal of membrane biology, 246(2), 121-129 (2012-11-03)
The mathematical model of Abdekhodaie and Wu (J Membr Sci 335:21-31, 2009) of glucose-responsive composite membranes for closed-loop insulin delivery is discussed. The glucose composite membrane contains nanoparticles of an anionic polymer, glucose oxidase and catalase embedded in a hydrophobic
T Shigeta et al.
Transplantation proceedings, 44(4), 946-947 (2012-05-09)
Grafts from donation after cardiac death (DCD) will greatly contribute to the expand the donor pool. However, these grafts may require the development of the preservation methods because of primary nonfunction and severe ischemic bile duct injury. Porcine livers were
Matthias Frommhagen et al.
Biotechnology for biofuels, 8, 101-101 (2015-07-18)
Many agricultural and industrial food by-products are rich in cellulose and xylan. Their enzymatic degradation into monosaccharides is seen as a basis for the production of biofuels and bio-based chemicals. Lytic polysaccharide monooxygenases (LPMOs) constitute a group of recently discovered
Loryn R Keating et al.
Talanta, 146, 594-602 (2015-12-24)
The mechanism of detection in pulsed electrochemical detection (PED) requires preadsorption of the analyte to the working electrode prior to its subsequent oxidation. Indirect detection is accomplished by the addition of a PED-active reagent to the mobile phase, whose signal
J D Shoemaker et al.
Journal of chromatography, 562(1-2), 125-138 (1991-01-02)
Eighty-five clinical urine samples and nineteen urine samples previously found by other laboratories to suggest genetic metabolic defects were prepared for trimethylsilylation by treatment with urease, followed by azeotropic dehydration. The "Target Analyte Search" program provided with the VG Trio
Takanori Nihira et al.
FEBS letters, 587(21), 3556-3561 (2013-09-24)
A novel phosphorylase was characterized as new member of glycoside hydrolase family 94 from the cellulolytic bacterium Xanthomonas campestris and the fungus Neurospora crassa. The enzyme catalyzed reversible phosphorolysis of cellobionic acid. We propose 4-O-β-D-glucopyranosyl-D-gluconic acid: phosphate α-D-glucosyltransferase as the
Rita Wegmüller et al.
The Journal of nutrition, 144(2), 132-136 (2013-11-22)
The water-soluble zinc salts gluconate, sulfate, and acetate are commonly used as supplements in tablet or syrup form to prevent zinc deficiency and to treat diarrhea in children in combination with oral rehydration. Zinc citrate is an alternative compound with
Carole Poiraud et al.
European journal of dermatology : EJD, 22(5), 634-639 (2012-08-03)
Antimicrobial peptides (AMPs) are a large family of peptides implicated in innate immunity, especially in the epidermis. Zinc gluconate has been proven to be efficient to treat inflammatory dermatoses, such as acne vulgaris. The aim of our work was to
Beatrice Arezzini et al.
European journal of medicinal chemistry, 43(11), 2549-2556 (2008-04-29)
A simple synthetic pathway to obtain glycosilated beta-diketo derivatives is proposed. These compounds show a good iron(III) affinity therefore we may suggest the use of their Fe(3+)-complexes as oral iron supplements in the treatment of anaemia. The glycosilated compounds (6-GlcH
Tobias Klein et al.
Biotechnology and bioengineering, 110(2), 535-542 (2012-08-14)
Chemostat cultivation is a powerful tool for physiological studies of microorganisms. We report the construction and application of a set of eight parallel small-scale bioreactors with a working volume of 10 mL for continuous cultivation. Hungate tubes were used as culture
Nehemiah Cox et al.
PloS one, 7(9), e45674-e45674 (2012-10-03)
Excessive NaCl intake is associated with a variety of fibrosing diseases such as renal and cardiac fibrosis. This association has been attributed to increased blood pressure as the result of high NaCl intake. However, studies in patients with high NaCl
Prajwal Raghunatha et al.
Glia, 68(7), 1421-1434 (2020-02-10)
Chronic neuroinflammation driven by microglia is a characteristic feature associated with numerous neurodegenerative diseases. While acute inflammation can assist with recovery and repair, prolonged microglial pro-inflammatory responses are known to exacerbate neurodegenerative processes. Yet, detrimental outcomes of extended microglial activation
Chia-Ni Lin et al.
Journal of analytical toxicology, 37(9), 665-669 (2013-07-12)
Methods for circumventing positive drug tests continue to evolve and are often spread through internet websites reporting on the proposed effectiveness of various adulteration methods. Recent claims of the use of zinc added directly to urine or ingested prior to
T Shigeta et al.
Transplantation proceedings, 44(4), 942-945 (2012-05-09)
The aims of this study were to compare extracellular and intracellular-type University of Wisconsin (UW) solutions for liver grafts and to assess oxygenation in this perfusion system. The organ preservation system consisted of 3 circulating systems for the portal vein
John O DiRaddo et al.
Molecular pharmacology, 88(3), 450-459 (2015-06-20)
The elemental anion chloride is generally considered a passive participant in neuronal excitability, and has never been shown to function as an agonist in its own right. We show that the antagonist-mediated, glutamate-independent inverse agonism of group II and III
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