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Danielle L Gomez et al.
PloS one, 10(8), e0133862-e0133862 (2015-08-20)
Neurogenin 3 (NGN3) is necessary and sufficient for endocrine differentiation during pancreatic development and is expressed by a population of progenitor cells that give rise exclusively to hormone-secreting cells within islets. NGN3 protein can be detected in the adult rodent
Eva Ludvigsen et al.
Upsala journal of medical sciences, 120(3), 157-168 (2015-05-01)
Somatostatin acts through five receptor subtypes (SSTRs 1-5). We aimed to investigate SSTRs mRNA expression and protein distribution in whole rat embryos, with special emphasis on the pancreas. Rat embryos were collected on embryonal days 10, 11, 12, 14, 15
Yingxu Ma et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(11), 14863-14877 (2020-09-13)
Appropriate control of hepatic gluconeogenesis is essential for the organismal survival upon prolonged fasting and maintaining systemic homeostasis under metabolic stress. Here, we show protein arginine methyltransferase 1 (PRMT1), a key enzyme that catalyzes the protein arginine methylation process, particularly
Kanako Tamura et al.
PloS one, 10(5), e0126003-e0126003 (2015-05-06)
Glucagon-like peptide-1 (GLP-1) receptor agonists potentiate glucose-induced insulin secretion. In addition, they have been reported to increase pancreatic beta cell mass in diabetic rodents. However, the precise mode of action of GLP-1 receptor agonists still needs to be elucidated. Here
Kazuto Taniguchi et al.
Diabetologia, 58(9), 2056-2063 (2015-06-10)
In humans, the rate of beta cell proliferation declines rapidly during the postnatal period and remains low throughout adult life. Recent studies suggest that this may reflect the distribution of cell cycle regulators which, unusually, are located in the cytosolic
Ahmed M Abdellatif et al.
Experimental animals, 64(3), 305-312 (2015-04-29)
The members of the MAF family of transcription factors are homologs of v-Maf -the oncogenic component of the avian retrovirus AS42. The MAF family is subdivided into 2 groups, small and large MAFs. To elucidate the role of the large
S T Glenn et al.
Oncogene, 33(50), 5706-5715 (2013-12-03)
Efforts to model human pancreatic neuroendocrine tumors (PanNETs) in animals have been moderately successful, with minimal evidence for glucagonomas or metastatic spread. The renin gene, although classically associated with expression in the kidney, is also expressed in many other extrarenal
Lili Ren et al.
Cells, tissues, organs, 199(5-6), 329-341 (2014-12-05)
Human adipose tissue-derived stem cells (hASCs) are considered an ideal tool for the supply of insulin-producing cells to treat diabetes mellitus, with high differentiation efficiency. Islet neogenesis-associated protein (INGAP) is an initiator of islet neogenesis, and the peptide sequence comprising
Ryuichi Wada et al.
Endocrine pathology, 25(4), 390-396 (2014-08-15)
Neuroendocrine neoplasm (NEN) of the pancreas and gastrointestinal tract is infrequent but often produces hormones to cause distinct clinical features. Glucagon-like peptide-1 receptor (GLP1R) is a G-protein coupled receptor for GLP1, which is cleaved by dipeptidyl peptidase (DPP)-IV, a peptidase
Camille Huet et al.
The Journal of biological chemistry, 295(18), 5836-5849 (2020-03-19)
The cellular energy sensor AMP-activated protein kinase (AMPK) is a metabolic regulator that mediates adaptation to nutritional variations to maintain a proper energy balance in cells. We show here that suckling-weaning and fasting-refeeding transitions in rodents are associated with changes
Li Ding et al.
Neoplasia (New York, N.Y.), 16(11), 909-917 (2014-11-27)
The role of tuberous sclerosis complex (TSC) in the pathogenesis of pancreatic cancers remains largely unknown. The present study shows that neurogenin 3 directed Cre deletion of Tsc1 gene induces the development of pancreatic acinar carcinoma. By cross-breeding the Neurog3-cre
Patricia de Godoy Bueno et al.
PloS one, 10(4), e0124369-e0124369 (2015-04-30)
The purpose of this study was to investigate the effects of multiple infusions of allogeneic MSCs on glucose homeostasis and morphometry of pancreatic islets in high- fat diet (HFD) fed mice. Swiss mice were fed standard diet (C group) or
Chenghu Huang et al.
International journal of molecular medicine, 36(1), 173-185 (2015-05-16)
The number of pro-α cells is known to increase in response to β cell injury and these cells then generate glucagon-like peptide-1 (GLP-1), thus attenuating the development of diabetes. The aim of the present study was to further examine the
Robert W Holdcraft et al.
Cell transplantation, 23(8), 929-944 (2013-05-03)
The transplantation of porcine islets of Langerhans to treat type 1 diabetes may provide a solution to the demand for insulin-producing cells. Porcine islets encapsulated in agarose-agarose macrobeads have been shown to function in nonimmunosuppressed xenogeneic models of both streptozotocin-induced
B Brackeva et al.
Journal of proteomics, 117, 156-167 (2015-02-02)
There is a clinical need for plasma tests for real-time detection of beta cell destruction, as surrogate endpoint in islet transplantation and immunoprevention trials in type 1 diabetes. This study reports on the use of label-free LC-MS/MS proteomics for bottom-up
Yuko Takano et al.
PloS one, 10(7), e0133812-e0133812 (2015-07-21)
Animal models with defective glucagon action show hyperplasia of islet α-cells, however, the regulatory mechanisms underlying the proliferation of islet endocrine cells remain largely to be elucidated. The Gcggfp/gfp mice, which are homozygous for glucagon/green fluorescent protein knock-in allele (GCGKO)
Shiva Reddy et al.
Diabetologia, 58(5), 1024-1035 (2015-02-18)
The role of peri-islet CD45-positive leucocytes, as one component of insulitis, in beta cell death during human type 1 diabetes remains unclear. We undertook a case study, comparing and quantifying leucocytes in the peri- and intra-islet areas in insulin-positive and
Liehua Liu et al.
Biochemical and biophysical research communications, 453(3), 398-404 (2014-10-01)
Dipeptidyl peptidase 4 (DPP-4) was recently found to be expressed in human and mouse islets with different expression patterns. However, whether species-dependent expression pattern is a generalized phenomenon and whether islet DPP-4 activity is regulated are not known. This study
Orison O Woolcott et al.
PloS one, 10(4), e0123558-e0123558 (2015-04-10)
Obesity has been associated with elevated plasma anandamide levels. In addition, anandamide has been shown to stimulate insulin secretion in vitro, suggesting that anandamide might be linked to hyperinsulinemia. To determine whether high-fat diet-induced insulin resistance increases anandamide levels and
Aikaterini Theodoraki et al.
Molecular and cellular endocrinology, 399, 296-310 (2014-09-17)
Heparan sulphate proteoglycans (HSPGs) exist in pancreatic beta cells, and HS seems to modulate important interactions in the islet microenvironment. However, the intra-islet structures of HS in health or altered glucose homeostasis are currently unknown. Here we show that distinct
Problem or solution: The strange story of glucagon
Scott RV and Bloom SR
Peptides, 100, 36-41 (2018)
Teresa L Mastracci et al.
Scientific reports, 5, 13269-13269 (2015-08-25)
The pancreas, in most studied vertebrates, is a compound organ with both exocrine and endocrine functions. The exocrine compartment makes and secretes digestive enzymes, while the endocrine compartment, organized into islets of Langerhans, produces hormones that regulate blood glucose. High
Aliye Uc et al.
Clinical science (London, England : 1979), 128(2), 131-142 (2014-08-22)
Diabetes is a common and significant co-morbidity in cystic fibrosis (CF). The pathogenesis of cystic fibrosis related diabetes (CFRD) is incompletely understood. Because exocrine pancreatic disease is similar between humans and pigs with CF, the CF pig model has the
Dan-Dan Yin et al.
World journal of gastroenterology, 20(22), 6884-6896 (2014-06-20)
To investigate the effect of mesothelin in the remodeling of the endocrine pancreas in neonatal rats. Overexpression or downregulation of mesothelin expression in INS-1 cells was carried out to investigate the effect of mesothelin during cell proliferation and cell apoptosis
Jiaxi Chen et al.
Diabetologia, 58(5), 1036-1044 (2015-02-28)
ANGPTL8 is a circulatory hormone secreted from liver and adipose tissue that promotes pancreatic beta cell proliferation and interferes with triacylglycerol metabolism in mice. The clinical significance of its effects on inducing beta cell proliferation is limited because it causes
Wook Kim et al.
FEBS letters, 588(17), 3233-3239 (2014-07-16)
Pancreatic polypeptide (PP) is a major agonist for neuropeptide Y4 receptors (NPY4R). While NPY4R has been identified in various tissues, the cells on which it is expressed and its function in those cells has not been clearly delineated. Here we
Idit Ron et al.
JCI insight, 6(20) (2021-10-23)
During pregnancy, fetal glucose production is suppressed, with rapid activation immediately postpartum. Fatty acid-binding protein 4 (FABP4) was recently demonstrated as a regulator of hepatic glucose production and systemic metabolism in animal models. Here, we studied the role of FABP4
Lipodystrophy due to adipose tissue-specific insulin receptor knockout results in progressive NAFLD
Softic S, et al.
Diabetes, 65(8), 2187-2200 (2016)
Christopher J Lelliott et al.
PloS one, 9(11), e112109-e112109 (2014-11-27)
We have generated a novel monoclonal antibody targeting human FGFR1c (R1c mAb) that caused profound body weight and body fat loss in diet-induced obese mice due to decreased food intake (with energy expenditure unaltered), in turn improving glucose control. R1c
Tsutomu Sasaki et al.
Endocrine journal, 62(9), 787-796 (2015-06-23)
Type 2 diabetes mellitus (T2DM) is one of the major health concern among the world. Several treatment options for T2DM are in clinical use, including injecting insulin, promoting insulin secretion by insulin secretagogues, and improving insulin sensitivity by insulin sensitizers.
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