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G2269

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Valeriya Lyssenko et al.
Diabetes, 60(9), 2424-2433 (2011-08-04)
The incretin hormone GIP (glucose-dependent insulinotropic polypeptide) promotes pancreatic β-cell function by potentiating insulin secretion and β-cell proliferation. Recently, a combined analysis of several genome-wide association studies (Meta-analysis of Glucose and Insulin-Related Traits Consortium [MAGIC]) showed association to postprandial insulin...
A J Moody et al.
FEBS letters, 172(2), 142-148 (1984-07-09)
Human GIP 1-42 and fragments of human GIP corresponding to GIP 10-42, GIP 11-42, and GIP 17-42 were isolated from acid-ethanol extracts of human small intestines with the aid of an anti-GIP serum specific for the extreme C-terminal portion of...
Synthesis of a 42 residue peptide corresponding to the entire amino acid sequence of human GIP.
H Yajima et al.
Chemical & pharmaceutical bulletin, 33(8), 3578-3581 (1985-08-01)
Priya Sumithran et al.
The New England journal of medicine, 365(17), 1597-1604 (2011-10-28)
After weight loss, changes in the circulating levels of several peripheral hormones involved in the homeostatic regulation of body weight occur. Whether these changes are transient or persist over time may be important for an understanding of the reasons behind...
Jennifer D Könitzer et al.
mAbs, 9(3), 536-549 (2017-01-06)
Raising functional antibodies against G protein-coupled receptors (GPCRs) is challenging due to their low density expression, instability in the absence of the cell membrane's lipid bilayer and frequently short extracellular domains that can serve as antigens. In addition, a particular...
Sabrina Paratore et al.
Central nervous system agents in medicinal chemistry, 11(3), 210-222 (2011-09-17)
The development of neuronal apoptosis depends on an intrinsic transcriptional program. By DNA microarray technology, we have previously implicated a number of genes in different paradigms of neuronal apoptosis. In the present study, we investigated the spatiotemporal pattern of expression...
Nigel Irwin et al.
Biological chemistry, 392(10), 909-918 (2011-08-20)
Effects of insulin excess and deficiency on glucose-dependent insulinotropic polypeptide (GIP) was examined in rats following insulinoma transplantation or streptozotocin (STZ) administration. Over 14 days, food intake was increased (p < 0.001) in both groups of rats, with decreased body...
Diabetes remission after bariatric surgery: is it just the incretins?
Laferrere B.
International Journal of Obesity, 35, S22-S25 (2011)
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