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Seila Fernandez-Fernandez et al.
Redox biology, 19, 52-61 (2018-08-15)
Loss of brain glutathione has been associated with cognitive decline and neuronal death during aging and neurodegenerative diseases. However, whether decreased glutathione precedes or follows neuronal dysfunction has not been unambiguously elucidated. Previous attempts to address this issue were approached
Tracy O'Connor et al.
Cancer cell, 36(3), 250-267 (2019-09-19)
How lymphoma cells (LCs) invade the brain during the development of central nervous system lymphoma (CNSL) is unclear. We found that NF-κB-induced gliosis promotes CNSL in immunocompetent mice. Gliosis elevated cell-adhesion molecules, which increased LCs in the brain but was
Katharine A Kenyon et al.
The Journal of comparative neurology, 518(16), 3169-3183 (2010-06-25)
Regulation of intracellular calcium is crucial both for proper neuronal function and survival. By coupling ATP hydrolysis with Ca(2+) extrusion from the cell, the plasma membrane calcium-dependent ATPases (PMCAs) play an essential role in controlling intracellular calcium levels in neurons.
Shu-Ting Liu et al.
Acta neuropathologica communications, 6(1), 111-111 (2018-10-26)
It was previously shown that EphB/ephrinB reverse signaling in retinal ganglion cells (RGCs) is activated and involved in RGC apoptosis in a rat chronic ocular hypertension (COH) model. In the present work, we first show that ephrinB/EphB forward signaling was
Plasma glial fibrillary acidic protein in the differential diagnosis of intracerebral hemorrhage
Katsanos AH, et al.
Stroke, 48(9), 2586 -22588 (2017)
Anabelle Planques et al.
eNeuro, 6(2) (2019-05-09)
Proliferation and migration during adult neurogenesis are regulated by a microenvironment of signaling molecules originating from local vasculature, from CSF produced by the choroid plexus, and from local supporting cells including astrocytes. Here, we focus on the function of OTX2
M Inagaki et al.
Brain pathology (Zurich, Switzerland), 4(3), 239-243 (1994-07-01)
Glial fibrillary acidic protein (GFAP) is an intermediate filament (IF) protein of astroglia, and belongs to the type III subclass of IF proteins. IF proteins are composed of an amino-terminal HEAD domain, a central ROD domain and a carboxyterminal TAIL
Elena Agostoni et al.
Frontiers in cellular neuroscience, 10, 110-110 (2016-05-21)
Huntington's disease (HD) is a fatal, dominantly inherited, neurodegenerative disorder due to a pathological expansion of the CAG repeat in the coding region of the HTT gene. In the quest for understanding the molecular basis of neurodegeneration, we have previously
N Amin et al.
Molecular psychiatry, 23(5), 1120-1126 (2017-03-23)
Depression is the most prevalent psychiatric disorder with a complex and elusive etiology that is moderately heritable. Identification of genes would greatly facilitate the elucidation of the biological mechanisms underlying depression, however, its complex etiology has proved to be a
Karina Kaczmarek-Hajek et al.
eLife, 7 (2018-08-04)
The P2X7 channel is involved in the pathogenesis of various CNS diseases. An increasing number of studies suggest its presence in neurons where its putative functions remain controversial for more than a decade. To resolve this issue and to provide
Linnea R Vose et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(44), 17232-17246 (2013-11-01)
Intraventricular hemorrhage (IVH) remains a major cause of white matter injury in preterm infants with no viable therapeutic strategy to restore myelination. Maturation of oligodendrocytes and myelination is influenced by thyroid hormone (TH) signaling, which is mediated by TH receptor
Laura Micheli et al.
Frontiers in cell and developmental biology, 9, 696684-696684 (2021-09-07)
The dentate gyrus of the hippocampus and the subventricular zone are neurogenic niches where neural stem and progenitor cells replicate throughout life to generate new neurons. The Btg1 gene maintains the stem cells of the neurogenic niches in quiescence. The
Laura Micheli et al.
Neuropharmacology, 141, 316-330 (2018-08-25)
The dentate gyrus of the hippocampus and the subventricular zone are neurogenic niches where the production of new neurons from glia-like stem cells continues throughout adult life. It is not clear whether the pool of stem cells is fated to
Theodora Mourtzi et al.
Stem cell research & therapy, 12(1), 335-335 (2021-06-12)
Loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) underlines much of the pathology of Parkinson's disease (PD), but the existence of an endogenous neurogenic system that could be targeted as a therapeutic strategy has been controversial. BNN-20
Libo Su et al.
Nucleic acids research, 46(17), 8817-8831 (2018-07-10)
Astrocytes play crucial roles in the central nervous system, and defects in astrocyte function are closely related to many neurological disorders. Studying the mechanism of gliogenesis has important implications for understanding and treating brain diseases. Epigenetic regulations have essential roles
Yohan van de Looij et al.
Frontiers in endocrinology, 10, 46-46 (2019-02-26)
Introduction: Intrauterine Growth Restriction (IUGR) refers to an impaired development of the fetus and hence results in adverse neurodevelopmental and psychiatric consequences later in life. Lactoferrin (Lf) is a glycoprotein present in milk that has already shown neuroprotective effects through
Martina Parrini et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 29(10), 3072-3092 (2021-06-01)
A common feature of diverse brain disorders is the alteration of GABA-mediated inhibition because of aberrant, intracellular chloride homeostasis induced by changes in the expression and/or function of chloride transporters. Notably, pharmacological inhibition of the chloride importer NKCC1 is able
Elke-Astrid Atzpodien et al.
Toxicologic pathology, 44(3), 398-413 (2015-12-19)
There is increased interest to use minipigs in ocular toxicology studies due to their anatomical similarities with human eyes and as a substitute for nonhuman primates. This requires adaptation of enhanced optical coherence tomography (OCT) techniques and of ocular relevant
Lipopolysaccharide differentially modulates expression of cytokines and cyclooxygenases in dorsal root ganglion cells via Toll-like receptor-4 dependent pathways
Tse KH, et al.
Neuroscience, 267, 241 -2251 (2014)
Pedro Ozorio Brum et al.
Neurochemical research (2021-09-25)
Neuroblastoma is the most common extracranial solid tumour in childhood, originated from cells of the neural crest during the development of the Sympathetic Nervous System. Retinoids are vitamin-A derived differentiating agents utilised to avoid disease resurgence in high-risk neuroblastoma treatment.
Muhammad T K Zia et al.
Experimental neurology, 263, 200-213 (2014-09-30)
Postnatal glucocorticoids (GCs) are widely used in the prevention of chronic lung disease in premature infants. Their pharmacologic use is associated with neurodevelopmental delay and cerebral palsy. However, the effect of GC dose and preparation (dexamethasone versus betamethasone) on short
TWO CASES WITH DIFFERENT EPILEPSY TYPE AND DYSMORPHIC FEATURES ASSOCIATED WITH 17q21. 31 MICRODELETION SYNDROME
Uctepe E, et al.
Genetic Counseling (Geneva, Switzerland), 27(3), 357-365 (2016)
Jongkyun Kang et al.
STAR protocols, 2(3), 100654-100654 (2021-07-22)
Quantitative assessment of neuropathological changes is essential for the characterization of animal models of neurodegenerative disease. Here, we describe a detailed protocol for the detection and quantification of key neuropathological changes in Alzheimer's mouse models. The protocol covers detailed methods
M S Vieira-Rocha et al.
Vascular pharmacology, 117, 27-34 (2018-10-17)
Fetal stress increases the susceptibility to cardiovascular diseases in adult age, including hypertension, a process known as fetal programming of hypertension (FPH). This study intends to investigate the interplay between vascular sympathetic nervous system (SNS) and RAS, namely the neuromodulatory
Preeti Dohare et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 36(11), 3363-3377 (2016-03-18)
Intraventricular hemorrhage (IVH) in preterm infants leads to cerebral inflammation, reduced myelination of the white matter, and neurological deficits. No therapeutic strategy exists against the IVH-induced white matter injury. AMPA-kainate receptor induced excitotoxicity contributes to oligodendrocyte precursor cell (OPC) damage
Giorgio D'Andrea et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(3), 4512-4526 (2020-02-07)
The dentate gyrus of the hippocampus is one of two brain areas generating throughout life new neurons, which contribute to the formation of episodic/associative memories. During aging, the production of new neurons decreases and a cognitive decline occurs. Dietary factors
Glial fibrillary acidic protein (GFAP) and the astrocyte intermediate filament system in diseases of the central nervous system
Hol EM and Pekny M
Current Opinion in Cell Biology, 32, 121-130 (2015)
Laura Micheli et al.
Frontiers in cellular neuroscience, 13, 10-10 (2019-02-23)
In the neurogenic niches-the dentate gyrus of the hippocampus and the subventricular zone (SVZ) adjacent to lateral ventricles-stem cells continue to divide during adulthood, generating progenitor cells and new neurons, and to self-renew, thus maintaining the stem cell pool. During
Rikke R Hansen et al.
Pain, 157(3), 666-676 (2015-11-18)
Severe pain is a common and debilitating complication of metastatic bone cancer. Current analgesics provide insufficient pain relief and often lead to significant adverse effects. In models of cancer-induced bone pain, pathological sprouting of sensory fibers at the tumor-bone interface
Belén Calvo et al.
IBRO reports, 8, 36-47 (2020-03-28)
The technical difficulty to isolate microglia, astrocytes and infiltrating immune cells from mouse brain is nowadays a limiting factor in the study of neuroinflammation. Brain isolation requirements are cell-type and animal-age dependent, but current brain dissociation procedures are poorly standardized.
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