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Henrik D Møller et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(24), E3114-E3122 (2015-06-04)
Examples of extrachromosomal circular DNAs (eccDNAs) are found in many organisms, but their impact on genetic variation at the genome scale has not been investigated. We mapped 1,756 eccDNAs in the Saccharomyces cerevisiae genome using Circle-Seq, a highly sensitive eccDNA
Daniel Wan et al.
PLoS neglected tropical diseases, 8(9), e3124-e3124 (2014-09-26)
Parasite-specific IgE is thought to correlate with protection against Schistosoma mansoni infection or re-infection. Only a few molecular targets of the IgE response in S. mansoni infection have been characterised. A better insight into the basic mechanisms of anti-parasite immunity
Ming-Hsien Chien et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 21(20), 4719-4732 (2015-06-17)
Kelch-like ECH-associated protein 1 (Keap1) is an E3 ligase participated in the cellular defense response against oxidative stress through nuclear factor erythroid-2-related factor 2 (Nrf2). However, the role of Keap1 in regulating cancer motility is still controversial. We investigated the
Jennifer Martinez et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(28), 9281-9289 (2014-07-11)
Neurons in the CNS do not regenerate following injury; regeneration is blocked by inhibitory proteins in myelin, such as myelin-associated glycoprotein (MAG). Elevating neuronal levels of the second messenger cAMP overcomes this blocked axonal outgrowth. One way to elevate cAMP
Hai Lin et al.
American journal of rhinology & allergy, 29(1), e18-e23 (2015-01-16)
The pathogenesis of human chronic rhinosinusitis (CRS) remains controversial. Recent evidence has suggested that interleukin (IL)-9 is vital in eliciting inflammatory response, stimulating cell proliferation and preventing apoptosis, through binding to the IL-9 receptor (IL-9R). However, little is known about
Harriët Schellekens et al.
ACS chemical neuroscience, 6(7), 1186-1197 (2015-03-03)
Understanding the intricate pathways that modulate appetite and subsequent food intake is of particular importance considering the rise in the incidence of obesity across the globe. The serotonergic system, specifically the 5-HT2C receptor, has been shown to be of critical
Sarmistha Bandyopadhyay et al.
PloS one, 9(10), e109525-e109525 (2014-10-09)
Francisella tularensis is a Gram-negative, facultative intracellular pathogen that replicates in the cytosol of macrophages and is the causative agent of the potentially fatal disease tularemia. A characteristic feature of F. tularensis is its limited proinflammatory capacity, but the mechanisms
Heidi Stoll et al.
Biomicrofluidics, 9(3), 034111-034111 (2015-07-17)
Aptamers are promising cell targeting ligands for several applications such as for the diagnosis, therapy, and drug delivery. Especially, in the field of regenerative medicine, stem cell specific aptamers have an enormous potential. Using the combinatorial chemistry process SELEX (Systematic
Lei Zhang et al.
International journal of clinical and experimental medicine, 8(4), 5591-5600 (2015-07-02)
To investigate the roles of matrine in regulating immune functions and its effect on the proliferation of leukemic cells. Human leukemia K562, OUN-1, HL-60, U937, K562/AO2 cell lines and primary leukemic cells were used to detect the NKG2D ligands (NKG2DL)
Katarina Turáková et al.
Anticancer research, 35(5), 2627-2634 (2015-05-13)
P-glycoprotein (Pgp) expression in neoplastic cells is known to reduce cell sensitivity to several cytotoxic Pgp substrates. A member of the ABC transporter family, Pgp, represents the most frequently described membrane efflux pump and its expression in neoplastic cells is
Rostyslav Zvanych et al.
Molecular bioSystems, 11(1), 97-104 (2014-09-12)
Streptococcus mutans, a Gram-positive human commensal and pathogen, is commonly recognized as a primary causative agent in dental caries. Metabolic activity of this strain results in the creation of acids and secreted products are recognized as pathogenic factors and agents
Ibrahim Alanazi et al.
PloS one, 10(3), e0120337-e0120337 (2015-03-18)
MiRNAs are known to regulate gene expression and in the context of cancer have been shown to regulate metastasis, cell proliferation and cell death. In this report we describe potential miRNA regulatory roles with respect to induction of cell death
Sara Ciulli et al.
Journal of virological methods, 213, 164-173 (2014-12-20)
Lymphocystis disease virus (LCDV) is responsible for a chronic self-limiting disease that affects more than 125 teleosts. Viral isolation of LCDV is difficult, time-consuming and often ineffective; the development of a rapid and specific tool to detect and quantify LCDV
Hong Yang et al.
Experimental and molecular pathology, 97(3), 590-599 (2014-12-03)
The effect of IL-10 on macrophage migration was investigated, including the analysis of protein expression, cytokine secretion and activation of the MAPKs and NF-kB pathway. The expression of endogenic IL-10 was down-regulated in macrophage stimulated with oxLDL for indicated time.
Min Huang et al.
BMC complementary and alternative medicine, 15, 146-146 (2015-05-13)
Geranium wilfordii is one of the major species used as Herba Geranii (lao-guan-cao) in China, it is commonly used solely or in polyherbal formulations for treatment of joint pain resulted from rheumatoid arthritis (RA) and gout. This herb is used
Eva Hagforsen et al.
Experimental dermatology, 24(7), 516-521 (2015-03-27)
Mast cells are known to have a detrimental impact on numerous types of inflammatory skin diseases such as contact dermatitis, atopic eczema and cutaneous mastocytosis. Regimens that dampen skin mast cell-mediated activities can thus offer an attractive therapeutic option under
Johanna Raffetseder et al.
PloS one, 9(11), e112426-e112426 (2014-11-12)
The standard treatment of tuberculosis (TB) takes six to nine months to complete and this lengthy therapy contributes to the emergence of drug-resistant TB. TB is caused by Mycobacterium tuberculosis (Mtb) and the ability of this bacterium to switch to
Lei Xu et al.
Journal of molecular and cellular cardiology, 77, 86-101 (2014-09-27)
The cell-permeant peptide inhibitor of MAPKAP kinase 2 (MK2), MMI-0100, inhibits MK2 and downstream fibrosis and inflammation. Recent studies have demonstrated that MMI-0100 reduces intimal hyperplasia in a mouse vein graft model, pulmonary fibrosis in a murine bleomycin-induced model and
William A Banks et al.
Journal of neuroinflammation, 12, 223-223 (2015-11-27)
Disruption of the blood-brain barrier (BBB) occurs in many diseases and is often mediated by inflammatory and neuroimmune mechanisms. Inflammation is well established as a cause of BBB disruption, but many mechanistic questions remain. We used lipopolysaccharide (LPS) to induce
Mijeong Jeon et al.
Archives of oral biology, 59(10), 1013-1023 (2014-06-25)
Stem cells from human exfoliated deciduous teeth (SHED) are a good source of dental tissue for regeneration therapy, and can be obtained using different primary culture methods. The aim of this study was to determine the differences in the in
A Y Liu et al.
Clinical and experimental immunology, 180(3), 509-519 (2015-02-06)
Infants exposed to maternal HIV-1 provide an opportunity to assess correlates of HIV-1-specific interferon (IFN)-γ responses and may be informative in the development of HIV-1 vaccines. HIV-1-infected women with CD4 counts 200-500 cells/mm(3) were randomized to short-course zidovudine/nevirapine (ZDV/NVP) or
Zachary D Stolp et al.
Journal of biomolecular screening, 20(5), 616-626 (2015-03-01)
The DenV pre-membrane protein (prM) is a crucial chaperone for the viral envelope protein, preventing premature fusion with vesicles during viral export. prM molecules in immature particles are cleaved by host proteases, leading to mature fusogenic virions. Blockade of prM
Li Xing et al.
Biochimica et biophysica acta, 1844(10), 1757-1764 (2014-07-27)
RNA helicase A (RHA), a DExD/H box protein, plays critical roles in a wide variety of cellular or viral functions. RHA contains a conserved core helicase domain that is flanked by five other domains. Two double-stranded RNA binding domains (dsRBD1
Mark A Gillespie et al.
The EMBO journal, 34(9), 1244-1258 (2015-03-11)
LXR-cofactor complexes activate the gene expression program responsible for cholesterol efflux in macrophages. Inflammation antagonizes this program, resulting in foam cell formation and atherosclerosis; however, the molecular mechanisms underlying this antagonism remain to be fully elucidated. We use promoter enrichment-quantitative
Maria Sol Degese et al.
The Biochemical journal, 467(1), 77-90 (2015-01-15)
Mitogen-activated protein kinase (MAPK) pathways constitute key regulatory elements linking extracellular stimuli to nuclear gene expression. Immediate-early responsive genes (IEGs) of the activator protein 1 (AP-1) family, such as fos, achieve peak expression levels shortly after cells are stimulated with
Chiung-Kuei Huang et al.
Journal of hepatology, 63(1), 191-198 (2015-03-01)
Alcoholic liver disease (ALD) is characterized by the development of fatty liver, alcoholic hepatitis, fibrosis and cirrhosis. However, the underlying mechanism(s) associated with progression remains elusive. Pro-inflammatory cytokines have been implicated in ALD progression due to pro-apoptotic effects on hepatocytes.
Naokazu Ibuki et al.
Molecular cancer therapeutics, 13(12), 2827-2839 (2014-10-01)
Insulin-like growth factor (IGF) signaling is associated with castrate-resistant prostate cancer (CRPC) progression. Insulin receptor substrates 1 and 2 (IRS1/2) mediate mitogenic and antiapoptotic signaling from IGF1 receptor (IGF1R), insulin receptor, and other oncoproteins. This study demonstrates that IRS1/2 expression
Randal A Byrn et al.
Antimicrobial agents and chemotherapy, 59(3), 1569-1582 (2014-12-31)
VX-787 is a novel inhibitor of influenza virus replication that blocks the PB2 cap-snatching activity of the influenza viral polymerase complex. Viral genetics and X-ray crystallography studies provide support for the idea that VX-787 occupies the 7-methyl GTP (m(7)GTP) cap-binding
Vanessa Bastos Pereira et al.
Applied microbiology and biotechnology, 99(4), 1817-1826 (2014-12-17)
The use of the food-grade bacterium Lactococcus lactis as a vehicle for the oral delivery of DNA vaccine plasmids constitutes a promising strategy for vaccination. The delivery of DNA plasmids into eukaryotic cells is of critical importance for subsequent DNA
Hironao Nakayama et al.
Scientific reports, 5, 11789-11789 (2015-07-15)
Semaphorin 3F (SEMA3F) provides neuronal guidance cues via its ability to bind neuropilin 2 (NRP2) and Plexin A family molecules. Recent studies indicate that SEMA3F has biological effects in other cell types, however its mechanism(s) of function is poorly understood.
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