Showing 1-30 of 1265 results for "G7126"
Z X Xie et al.
Journal of animal physiology and animal nutrition, 99(3), 492-500 (2014-10-01)
Increased levels of plasma free amino acids (pFAAs) can disturb the blood glucose levels in patients with obesity, diabetes mellitus and metabolic syndrome (MS) and are associated with enhanced protein oxidation. Oxidation of proteins, especially in the muscles, can promote...
Stefan Hausmann et al.
PloS one, 10(4), e0122689-e0122689 (2015-04-04)
Multiple myeloma (MM) is a generally fatal plasma cell cancer that often shows activation of the phosphoinositide 3-kinase/Akt (PI3K/Akt) pathway. Targeted pharmacologic therapies, however, have not yet progressed beyond the clinical trial stage, and given the complexity of the PI3K/Akt...
Jinsheng Xu et al.
Experimental and therapeutic medicine, 9(3), 1028-1034 (2015-02-11)
Vascular calcification, a common complication in patients with chronic kidney disease, involves a variety of mechanisms associated with the regulation of calcification-associated factors. Previous clinical studies have indicated that magnesium is involved in the reduction of vascular calcification; however, the...
Zheng-Quan Tang et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(40), 15964-15977 (2013-10-04)
Metabotropic glutamate receptor (mGluR)-dependent homosynaptic long-term depression (LTD) has been studied extensively at glutamatergic synapses in the CNS. However, much less is known about heterosynaptic long-term plasticity induced by mGluRs at inhibitory synapses. Here we report that pharmacological or synaptic...
Kazuaki Kawaura et al.
Behavioural brain research, 278, 186-192 (2014-10-11)
Glutamatergic dysfunction, particularly the hypofunction of N-methyl-D-aspartate (NMDA) receptors, is involved in the pathophysiology of schizophrenia. The positive modulation of the glycine site on the NMDA receptor has been proposed as a novel therapeutic approach for schizophrenia. However, its efficacy...
Yunxian Huang et al.
BMC genomics, 16, 427-427 (2015-06-05)
Limited nutrient availability during development is associated with metabolic diseases in adulthood. The molecular cause for these defects is unclear. Here, we investigate if transcriptional changes caused by developmental malnutrition reveal an early response that can be linked to metabolism...
Cai Li et al.
Neuropharmacology, 95, 154-167 (2015-03-23)
M-type (Kv7) K(+) channels, encoded by KCNQ2-KCNQ5 genes, play a pivotal role in controlling neuronal excitability. However, precisely how neuronal activity regulates Kv7 channel translocation has not yet been fully defined. Here we reported activity-dependent changes in Kv7 channel subunits...
Felipe Romero-Saavedra et al.
PloS one, 10(8), e0136625-e0136625 (2015-09-01)
Enterococcus faecium and faecalis are Gram-positive opportunistic pathogens that have become leading causes of nosocomial infections over the last decades. Especially multidrug resistant enterococci have become a challenging clinical problem worldwide. Therefore, new treatment options are needed and the identification...
Cristiano Pedrozo Vieira et al.
Anatomical record (Hoboken, N.J. : 2007), 298(3), 538-545 (2014-08-27)
Tendinopathy of the Achilles tendon is a clinical problem that motivates the scientific community to search for treatments that assist in restoring its functional properties. Glycine has broad biological effects, acting as a modulator of the inflammatory cascade, and is...
Brittany K Pierce et al.
PloS one, 9(11), e113504-e113504 (2014-11-27)
Xylella fastidiosa is a gram-negative, xylem-limited plant pathogenic bacterium that causes disease in a variety of economically important agricultural crops including Pierce's disease of grapevines. Xylella fastidiosa biofilms formed in the xylem vessels of plants play a key role in...
Xian Zhang et al.
Arteriosclerosis, thrombosis, and vascular biology, 40(3), 597-610 (2020-01-31)
By binding to its high-affinity receptor FcεR1, IgE activates mast cells, macrophages, and other inflammatory and vascular cells. Recent studies support an essential role of IgE in cardiometabolic diseases. Plasma IgE level is an independent predictor of human coronary heart...
Ichino Chinen et al.
International immunology, 27(8), 405-415 (2015-04-12)
Aryl hydrocarbon receptor (Ahr), a transcription factor, plays a critical role in autoimmune inflammation of the intestine. In addition, microRNAs (miRNAs), small non-coding oligonucleotides, mediate pathogenesis of inflammatory bowel diseases (IBD). However, the precise mechanism and interactions of these molecules...
Toru Sugiyama et al.
Molecules (Basel, Switzerland), 18(1), 287-310 (2012-12-29)
A peptide nucleic acid (PNA) is a synthetic nucleic acid mimic in which the sugar-phosphate backbone is replaced by a peptide backbone. PNAs hybridize to complementary DNA and RNA with higher affinity and superior sequence selectivity compared to DNA. PNAs...
Kriti Dubey et al.
Biochemical and biophysical research communications, 448(4), 480-484 (2014-05-08)
Both collagen and amyloidogenic proteins have an inherent ability to undergo a self-assembly process leading to formation of supramolecular structures. Though our understanding of collagen-amyloid link is very poor, a few experimental evidences have indicated the protective nature of collagen...
K J Bär et al.
Neurobiology of aging, 24(2), 333-338 (2002-12-25)
Increasing evidence suggests an interaction of oxidative stress and the formation of advanced glycation end products (AGE) in the onset and progression of Alzheimer's disease. We studied levels of pentosidine and N(epsilon)-(carboxymethyl)-lysine (CML) in serum and cerebrospinal fluid (CSF) of...
Berna Genc et al.
Journal of environmental biology, 36(6), 1319-1324 (2015-12-23)
In the present study, cellulase was purified and characterized from Anoxybacillus gonensis (Gen bank Number: KM596794) which was isolated and characterized from Agri Diyadin Hot spring. It was found to synthesize cellulase which had a wide range of industrial applications....
Ivana D'Andrea et al.
EMBO molecular medicine, 7(7), 904-917 (2015-04-18)
Although PI3Kγ has been extensively investigated in inflammatory and cardiovascular diseases, the exploration of its functions in the brain is just at dawning. It is known that PI3Kγ is present in neurons and that the lack of PI3Kγ in mice...
Xin Wang et al.
Plant cell reports, 34(5), 733-743 (2014-12-31)
Using Illumina sequencing technology, we have generated the large-scale transcriptome sequencing data and indentified many putative genes involved in isoflavones biosynthesis in Pueraria lobata. Pueraria lobata, a member of the Leguminosae family, is a traditional Chinese herb which has been...
Lenea Nørskov-Lauritsen et al.
FEBS letters, 589(5), 588-597 (2015-01-27)
Investigation of post-translational modifications of receptor proteins is important for our understanding of receptor pharmacology and disease physiology. However, our knowledge about post-translational modifications of class C G protein-coupled receptors and how these modifications regulate expression and function is very...
Etienne van Bracht et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 94, 141-151 (2015-05-09)
Lyophilisomes are a novel class of proteinaceous biodegradable nano/microparticle capsules developed for tumor drug delivery. The in vivo characteristics of lyophilisomes are unknown and, therefore, the time course of biodistribution of sized albumin-based lyophilisomes in CD1 mice after intravenous administration...
Tanja Kalstrup et al.
Scientific reports, 5, 11866-11866 (2015-07-15)
With the rapid development of a continuously growing selection of unnatural amino acids (UAAs), UAA insertion becomes increasingly popular for investigating proteins. However, it can prove problematic to ensure the homogeneity of the expressed proteins, when homogeneity is compromised by...
Rengasamy Palanivel et al.
Metabolism: clinical and experimental, 63(10), 1363-1373 (2014-08-12)
Adiponectin is known to confer its cardioprotective effects in obesity and type 2 diabetes, mainly by regulating glucose and fatty acid metabolism in cardiomyocytes. Dynamic actin cytoskeleton remodeling is involved in regulation of multiple biological functions, including glucose uptake. Here...
Zhihui Wang et al.
BMC genomics, 16, 1053-1053 (2015-12-15)
Plant bZIP proteins characteristically harbor a highly conserved bZIP domain with two structural features: a DNA-binding basic region and a leucine (Leu) zipper dimerization region. They have been shown to be diverse transcriptional regulators, playing crucial roles in plant development...
Hillary E Hoffman et al.
Journal of medicinal chemistry, 52(19), 6032-6041 (2009-10-02)
Mammalian serine racemase (SR) is a pyridoxal-5'-phosphate (PLP) dependent enzyme responsible for the biosynthesis of the neurotransmitter D-serine, which activates N-methyl-D-aspartate (NMDA) receptors in the CNS. Aberrant regulation of NMDA receptor signaling has been implicated in a variety of neuropathologies...
Françoise Myster et al.
Journal of virology, 89(7), 3630-3647 (2015-01-16)
Viral semaphorins are semaphorin 7A (sema7A) mimics found in pox- and herpesviruses. Among herpesviruses, semaphorins are encoded by gammaherpesviruses of the Macavirus genus only. Alcelaphine herpesvirus 1 (AlHV-1) is a macavirus that persistently infects wildebeest asymptomatically but induces malignant catarrhal...
Chenyu Mao et al.
Oncotarget, 6(8), 5707-5719 (2015-02-19)
To achieve specific and potent antitumor effect of hepatocyte carcinoma cells, replication defective adenoviral vectors, namely rAd/AFP-amiRG, rAd/AFP-amiRE and rAd/AFP-amiRP, were constructed which were armed with artificial microRNAs (amiRs) targeting essential functional genes glyceraldehyde-3-phosphate dehydrogenase, eukaryotic translation initiation factor 4E...
Jhi Biau Foo et al.
BMC complementary and alternative medicine, 14, 197-197 (2014-06-21)
Dillenia suffruticosa root dichloromethane extract (DCM-DS) has been reported to exhibit strong cytotoxicity towards breast cancer cells. The present study was designed to investigate the cell cycle profile, mode of cell death and signalling pathways of DCM-DS-treated human caspase-3 deficient...
Children with severe asthma have unique oxidative stress-associated metabolomic profiles.
Anne M Fitzpatrick et al.
The Journal of allergy and clinical immunology, 133(1), 258-261 (2013-12-29)
Jie Liu et al.
Biochemical and biophysical research communications, 465(2), 245-248 (2015-08-10)
The relation between the activity of the sperm specific glyceraldehyde-3-phosphate dehydrogenase (GAPDS) and the motility of sperms in diabetic men was investigated. It was found that the mean value of GAPDS activity and sperm motility in diabetic sperm samples is...
C Härnryd et al.
Psychopharmacology, 64(2), 131-134 (1979-08-08)
The effect of ECT on concentrations of monoamine metabolites in lumbar CSF of psychotic women with a schizophrenic symptomatology was examined. After a series of ECT there was a significant reduction of the concentration of the major noradrenaline metabolite, MOPEG....

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