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Rachel P Heilman et al.
American journal of physiology. Heart and circulatory physiology, 308(12), H1575-H1582 (2015-04-12)
Pulmonary hypertension (PH) and right ventricular hypertrophy (RVH) affect 25-35% of premature infants with significant bronchopulmonary dysplasia (BPD), increasing morbidity and mortality. We sought to determine the role of phosphodiesterase 5 (PDE5) in the right ventricle (RV) and left ventricle...
Jisha Joshua et al.
Endocrinology, 155(12), 4720-4730 (2014-09-05)
Osteoporosis is a major health problem leading to fractures that cause substantial morbidity and mortality. Current osteoporosis therapies have significant drawbacks, creating a need for novel bone-anabolic agents. We previously showed that the nitric oxide/cyclic GMP (cGMP)/protein kinase G pathway...
Qian Wang et al.
American journal of respiratory cell and molecular biology, 48(5), 610-618 (2013-03-09)
Edema fluid resorption is critical for gas exchange, and both alveolar epithelial sodium channel (ENaC) and Na,K-ATPase are accredited with key roles in the resolution of pulmonary edema. Alveolar fluid clearance (AFC) was measured in in situ ventilated lungs by...
Line A Mortensen et al.
American journal of physiology. Renal physiology, 317(3), F529-F539 (2019-06-06)
Kidney transplantation is associated with increased cardiovascular risk. Endothelial dysfunction and vascular inflammation contribute to negative outcome. In experimental models, mineralocorticoid receptor antagonists improved endothelial function and reduced inflammation. The present study tested the hypothesis that the mineralocorticoid receptor antagonist...
Rosa Mancinelli et al.
International journal of molecular sciences, 21(5) (2020-03-01)
Purines are nitrogen compounds consisting mainly of a nitrogen base of adenine (ABP) or guanine (GBP) and their derivatives: nucleosides (nitrogen bases plus ribose) and nucleotides (nitrogen bases plus ribose and phosphate). These compounds are very common in nature, especially...
Rodrigo B de Alexandre et al.
Endocrine-related cancer, 22(4), 519-530 (2015-05-17)
We hypothesized that mutations that inactivate phosphodiesterase (PDE) activity and lead to increased cAMP and cyclic guanosine monophosphate levels may be associated with prostate cancer (PCa). We sequenced the entire PDE coding sequences in the DNA of 16 biopsy samples...
Lu Li et al.
The Journal of nutrition, 150(9), 2287-2294 (2020-06-09)
Epidemiological studies have indicated an inverse association between citrus fruit consumption and cardiovascular disease (CVD) risk. There is, however, a paucity of data concerning effects of blood orange juice (BOJ) intake on endothelial function and cardiovascular risk biomarkers. We examined...
Jeffrey A Kline et al.
Nitric oxide : biology and chemistry, 96, 20-28 (2020-01-16)
We test if inhaled nitric oxide (NO) attenuates platelet functional and metabolic hyper-reactivity in subjects with submassive pulmonary embolism (PE). Participants with PE were randomized to either 50 ppm NO + O2 or O2 only for 24 h with blood sampling at enrollment and...
Yao Lu et al.
The Journal of surgical research, 193(1), 43-51 (2014-09-13)
Remote intrathecal morphine preconditioning (RMPC) induces cardioprotection, but the underlying mechanisms of this effect is unknown. The aim of this study was to investigate the role of spinal cord nitric oxide/cyclic guanosine monophosphate/protein kinase G (NO/cGMP/PKG) signal pathway in the...
Wiebke Kallenborn-Gerhardt et al.
Anesthesiology, 121(2), 372-382 (2014-04-25)
Phosphodiesterase 2A (PDE2A) is an evolutionarily conserved enzyme that catalyzes the degradation of the cyclic nucleotides, cyclic adenosine monophosphate, and/or cyclic guanosine monophosphate. Recent studies reported the expression of PDE2A in the dorsal horn of the spinal cord, pointing to...
Jacob T Regan et al.
Cells, 10(2) (2021-03-07)
C-type natriuretic peptide (CNP) is the major natriuretic peptide of the central nervous system and acts via its selective guanylyl cyclase-B (GC-B) receptor to regulate cGMP production in neurons, astrocytes and endothelial cells. CNP is implicated in the regulation of...
Qilin Gu et al.
Hepatology (Baltimore, Md.), 60(6), 1929-1941 (2014-08-19)
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disorder caused by abnormal lipid metabolisms, such as reduced hepatic fatty acid oxidation (FAO), but intracellular control of FAO under physio- and pathological conditions remains largely undefined. Here, we...
Linhui Qin et al.
Molecular nutrition & food research, 65(2), e2000810-e2000810 (2020-11-18)
Hyperglycemia-induced cardiac fibrosis is one of the main causes of diabetic cardiomyopathy (DM). Chlorogenic acid (CGA) found in many foods has excellent hypoglycemic effectiveness, but it is not known whether CGA can improve DM by inhibiting cardiac fibrosis caused by...
Maristella Donato et al.
International journal of molecular sciences, 21(21) (2020-11-08)
Calcific aortic valve stenosis (CAVS), the most common heart valve disease, is characterized by the slow progressive fibro-calcific remodeling of the valve leaflets, leading to progressive obstruction to the blood flow. CAVS is an increasing health care burden and the...
Heather-Marie P Wilson et al.
Clinical orthopaedics and related research, 473(9), 2908-2919 (2015-06-14)
Extremity trauma is the most common injury seen in combat hospitals as well as in civilian trauma centers. Major skeletal muscle injuries that are complicated by ischemia often result in substantial muscle loss, residual disability, or even amputation, yet few...
Nicole Urban et al.
Cells, 9(1) (2020-01-18)
(1) Background: Members of the TRPC3/TRPC6/TRPC7 subfamily of canonical transient receptor potential (TRP) channels share an amino acid similarity of more than 80% and can form heteromeric channel complexes. They are directly gated by diacylglycerols in a protein kinase C-independent...
Yang Chen et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 318(4), R669-R676 (2020-02-06)
Based on the cardiac hormone atrial natriuretic peptide (ANP) and its seminal role in blood pressure (BP) homeostasis, we investigated the chronic BP lowering actions of a novel ANP analog currently entering clinical trials for hypertension. Previous reports demonstrate that...
Donald T Weed et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 21(1), 39-48 (2014-10-17)
Myeloid-derived suppressor cells (MDSC) and regulatory T cells (Treg) play a key role in the progression of head and neck squamous cell carcinoma (HNSCC). On the basis of our preclinical data demonstrating that phosphodiesterase-5 (PDE5) inhibition can modulate these cell...
Cyclic GMP catabolism up-regulation in MRL/lpr lupus-prone mice is associated with organ remodeling.
Yougbare I, Keravis T, Abusnina A, et al.
Biochimica et Biophysica Acta, 1842(7), 916-926 (2014)
Konstantinos Koussis et al.
Life science alliance, 3(4) (2020-03-18)
Over recent years, a plethora of new genetic tools has transformed conditional engineering of the malaria parasite genome, allowing functional dissection of essential genes in the asexual and sexual blood stages that cause pathology or are required for disease transmission...
Ameliorative effect of phosphodiesterase 4 and 5 inhibitors in deoxycorticosterone acetate-salt hypertensive uni-nephrectomized KKAy mice.
Nio, et al.
Faseb Journal, 34, 14997-15014 (2021)
Valentina Rovella et al.
Nutrients, 13(2) (2021-03-07)
In the past few decades, obesity has reached pandemic proportions. Obesity is among the main risk factors for cardiovascular diseases, since chronic fat accumulation leads to dysfunction in vascular endothelium and to a precocious arterial stiffness. So far, not all...
Valentina Cannone et al.
Hypertension (Dallas, Tex. : 1979), 62(5), 860-865 (2013-09-18)
We analyzed the phenotype associated with the atrial natriuretic peptide (ANP) genetic variant rs5065 in a random community-based sample. We also assessed and compared the biological action of 2 concentrations (10(-10) mol/L, 10(-8) mol/L) of ANP and ANP-RR, the protein...
Gai-Xian Ren et al.
Environmental microbiology, 16(4), 1202-1216 (2013-11-07)
Yersinia pestis, the cause of plague, forms a biofilm in the foregut of its flea vector to enhance transmission. Biofilm formation in Y. pestis is controlled by the intracellular levels of the second messenger molecule cyclic diguanylate (c-di-GMP). HmsT and Y3730...
Stephanie D Nofal et al.
mBio, 12(1) (2021-01-28)
Guanylyl cyclases (GCs) synthesize cyclic GMP (cGMP) and, together with cyclic nucleotide phosphodiesterases, are responsible for regulating levels of this intracellular messenger which mediates myriad functions across eukaryotes. In malaria parasites (Plasmodium spp), as well as their apicomplexan and ciliate...
Physiology and pathophysiology of vascular signaling controlled by guanosine 3',5'-cyclic monophosphate-dependent protein kinase [corrected].
Thomas Münzel et al.
Circulation, 108(18), 2172-2183 (2003-11-05)
Jeremy R Egbert et al.
Development (Cambridge, England), 141(18), 3594-3604 (2014-09-04)
In mammals, the meiotic cell cycle of oocytes starts during embryogenesis and then pauses. Much later, in preparation for fertilization, oocytes within preovulatory follicles resume meiosis in response to luteinizing hormone (LH). Before LH stimulation, the arrest is maintained by...
Diego Fernando Dubeibe et al.
Zygote (Cambridge, England), 1-9 (2020-05-16)
This study aimed to assess the effects of the inhibition of nitric oxide synthase (NOS) on events that modulate bovine in vitro oocyte maturation. Cumulus-oocyte complexes (COCs) were cultured with hemisections (HSs) of the follicular walls in a maturation medium...
Emma Mitidieri et al.
Antioxidants (Basel, Switzerland), 9(10) (2020-10-01)
It is well-known that the physiological uterine peristalsis, related to several phases of reproductive functions, plays a pivotal role in fertility and female reproductive health. Here, we have addressed the role of hydrogen sulfide (H2S) signaling in changes of uterine...
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