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Massimiliano Filosto et al.
Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology, 32(2), 91-94 (2014-01-09)
Glycogenosis II (GSD II) is an autosomal recessive lysosomal storage disorder resulting from acid alpha-glucosidase deficiency, subsequent accumulation of glycogen in tissues, impairment of autophagic processes and progressive cardiac, motor and respiratory failure. The late-onset form is characterized by wide
Juan M Pascual et al.
JAMA neurology, 70(6), 756-763 (2013-04-24)
The physiological relevance of acid maltase (acid α-glucosidase, an enzyme that degrades lysosomal glycogen) is well recognized in liver and muscle. In late (adult)-onset acid maltase deficiency (glycogen storage disease type II [GSD II]), glycogen accumulates inside muscular lysosomes in
Carlos M Castorena et al.
Diabetes, 63(7), 2297-2308 (2014-03-13)
Earlier research on rats with normal insulin sensitivity demonstrated that acute exercise increased insulin-stimulated glucose uptake (GU) concomitant with greater phosphorylation of Akt substrate of 160 kDa (pAS160). Because mechanisms for exercise effects on GU in insulin-resistant muscle are unknown
Mari Hayashi et al.
BMC plant biology, 18(1), 59-59 (2018-04-11)
Starch is the major component of cereal grains and is composed of essentially linear amylose and highly branched amylopectin. The properties and composition of starch determine the use and value of grains and their products. Starch synthase (SS) I, SSIIa
M Clara P Amorim et al.
Physiology & behavior, 149, 192-198 (2015-06-07)
Acoustic communication during agonistic behaviour is widespread in fishes. Yet, compared to other taxa, little is known on the information content of fish agonistic calls and their effect on territorial defence. Lusitanian toadfish males (Halobatrachus didactylus) are highly territorial during
Eric A F Herbst et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 306(2), R102-R107 (2013-12-07)
During recovery from glycogen-depleting exercise, there is a shift from carbohydrate oxidation to glycogen resynthesis. The activity of the pyruvate dehydrogenase (PDH) complex may decrease to reduce oxidation of carbohydrates in favor of increasing gluconeogenic recycling of carbohydrate-derived substrates for
D Landon McPhee et al.
Aquatic toxicology (Amsterdam, Netherlands), 155, 91-100 (2014-07-08)
Selenium (Se) is known to cause chronic toxicity in aquatic species. In particular, dietary exposure of fish to selenomethionine (SeMet), the primary form of Se in the diet, is of concern. Recent studies suggest that chronic exposure to elevated dietary
Neeraj Verma et al.
Indian journal of experimental biology, 51(1), 65-72 (2013-02-28)
Antihyperglycemic potential of hyperin at 25 and 50 mg/kg doses for 30 days to streptozotocin induced diabetic rats has been reported. In oral glucose tolerance test, hyperin treated rats showed a significant reduction in blood glucose level after 120 min.
Suppression of autophagic activation in the mouse uterus by estrogen and progesterone.
Choi S, Shin H, Song H, et al.
The Journal of Endocrinology, 221(1), 39-50 (2014)
Gustavo Gomes de Araujo et al.
Laboratory animals, 47(1), 36-42 (2013-03-08)
This study was undertaken to characterize the effects of monotonous training at lactate minimum (LM) intensity on aerobic and anaerobic performances; glycogen concentrations in the soleus muscle, the gastrocnemius muscle and the liver; and creatine kinase (CK), free fatty acids
Jiaojiao Chu et al.
PloS one, 8(2), e57231-e57231 (2013-02-26)
Apelin, a novel adipokine, is the specific endogenous ligand of G protein-coupled receptor APJ. Consistent with its putative role as an adipokine, apelin has been linked to states of insulin resistance. However, the function of apelin in hepatic insulin resistance
Lisa C Heather et al.
Circulation. Heart failure, 6(5), 1058-1066 (2013-08-14)
Fatty acid and glucose transporters translocate between the sarcolemma and intracellular compartments to regulate substrate metabolism acutely. We hypothesised that during ischemia fatty acid translocase (FAT/CD36) would translocate away from the sarcolemma to limit fatty acid uptake when fatty acid
Rathishri Chandurvelan et al.
Aquatic toxicology (Amsterdam, Netherlands), 140-141, 303-313 (2013-07-24)
The biochemical responses of the green-lipped mussel, Perna canaliculus, to waterborne cadmium (Cd) were investigated in order to delineate toxic mechanisms, and the impacts of exposure dose and duration, of this important toxicant in a potential sentinel species. Mussels were
Ahmed Th A Ibrahim et al.
Ecotoxicology and environmental safety, 106, 33-39 (2014-05-20)
The present study examined the impacts of carbofuran on endocrinology of the catfish, Clarias gariepinus, for the first time and evaluated cortisol (CRT), triiodothyronine (T3), thyroxin (T4), 17β-estradiol (E2) and testosterone (TST) and the oxidative stress markers including SOD, CAT
M José Villarroel et al.
Environmental toxicology and pharmacology, 35(3), 465-472 (2013-03-19)
The present study investigates energy stores changes in the aquatic invertebrate Daphnia magna following a 5-d exposure to propanil. Juveniles of D. magna were exposed to sublethal propanil concentrations (0.07, 0.10, 0.21 and 0.55 mgl(-1)) which were used previously to
Daniela P Mesquita et al.
Analytica chimica acta, 770, 36-44 (2013-03-19)
The present study focuses on predicting the concentration of intracellular storage polymers in enhanced biological phosphorus removal (EBPR) systems. For that purpose, quantitative image analysis techniques were developed for determining the intracellular concentrations of PHA (PHB and PHV) with Nile
Ze-Hua Liu et al.
Water environment research : a research publication of the Water Environment Federation, 86(7), 663-671 (2014-08-13)
Two enhanced biological phosphorus removal (EBPR) sequencing batch reactors (SBR1, SBR2) treating liquid dairy manure were operated with the same hydraulic retention time (HRT) and solids retention time (SRT), but with different aeration cycles. During eight months of operation, both
Dang Hai Dang Nguyen et al.
Journal of bacteriology, 196(11), 1941-1949 (2014-03-13)
We studied the activity of a debranching enzyme (TreX) from Sulfolobus solfataricus on glycogen-mimic substrates, branched maltotetraosyl-β-cyclodextrin (Glc₄-β-CD), and natural glycogen to better understand substrate transglycosylation and the effect thereof on glycogen debranching in microorganisms. The validation test of Glc₄-β-CD
Timothy J Sullivan et al.
Metabolism: clinical and experimental, 62(11), 1623-1632 (2013-08-21)
CCR2 inhibition has produced promising experimental and clinical anti-hyperglycemic effects. These results support the thesis that insulin resistance and Type 2 diabetes (T2D) are associated with chronic unresolved inflammation. The aim of this study was to provide a broad analysis
Bridget E Lester et al.
Aviation, space, and environmental medicine, 84(8), 789-796 (2013-08-10)
Studies of real and simulated microgravity exposure show the lower limb muscles atrophy to the greatest extent, with the calf muscles being most affected and most difficult to target with exercise countermeasures. This ground-based study examined the metabolic involvement of
Thiago De Souza Candido et al.
The Biochemical journal, 464(3), 323-334 (2014-09-26)
Glycogen functions as a carbohydrate reserve in a variety of organisms and its metabolism is highly regulated. The activities of glycogen synthase and glycogen phosphorylase, the rate-limiting enzymes of the synthesis and degradation processes, respectively, are regulated by allosteric modulation
Joachim Nielsen et al.
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 38(2), 91-99 (2013-02-27)
Glucose is stored in skeletal muscle fibers as glycogen, a branched-chain polymer observed in electron microscopy images as roughly spherical particles (known as β-particles of 10-45 nm in diameter), which are distributed in distinct localizations within the myofibers and are
Valentina Gburcik et al.
American journal of physiology. Endocrinology and metabolism, 304(8), E885-E894 (2013-03-14)
Failure of white adipose tissue to appropriately store excess metabolic substrate seems to underpin obesity-associated type 2 diabetes. Encouraging "browning" of white adipose has been suggested as a therapeutic strategy to help dispose of excess stored lipid and ameliorate the
Mehdi Rahimpour et al.
The Biochemical journal, 452(3), 559-573 (2013-03-30)
Escherichia coli glycogen metabolism involves the regulation of glgBXCAP operon expression and allosteric control of the GlgC [ADPG (ADP-glucose) pyrophosphorylase]-mediated catalysis of ATP and G1P (glucose-1-phosphate) to ADPG linked to glycogen biosynthesis. E. coli glycogen metabolism is also affected by glgS.
Robyn G Lottes et al.
American journal of physiology. Lung cellular and molecular physiology, 306(10), L947-L955 (2014-04-01)
Although many lung diseases are associated with hypoxia, alveolar type II epithelial (ATII) cell impairment, and pulmonary surfactant dysfunction, the effects of O(2) limitation on metabolic pathways necessary to maintain cellular energy in ATII cells have not been studied extensively.
Fiore Manganelli et al.
Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology, 32(2), 82-84 (2014-01-09)
Glycogen storage disease type II - also called Pompe disease or acid maltase deficiency - is an autosomal recessive metabolic disorder, caused by an accumulation of glycogen in the lysosome due to deficiency of the lysosomal acid alpha-glucosidase enzyme. Pompe
A A Zhidenko et al.
Ukrains'kyi biokhimichnyi zhurnal (1999 ), 85(3), 22-30 (2013-08-14)
The use of glyphosate as a herbicide in agriculture can lead to the presence of its residues and metabolites (aminomethylphosphonic acid) in food for human consumption and pose a threat to health. The effect of these herbicides on the fish
Benjamin L Farah et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 28(5), 2272-2280 (2014-01-23)
Enzyme or gene replacement therapy with acid α-glucosidase (GAA) has achieved only partial efficacy in Pompe disease. We evaluated the effect of adjunctive clenbuterol treatment on cation-independent mannose-6-phosphate receptor (CI-MPR)-mediated uptake and intracellular trafficking of GAA during muscle-specific GAA expression
Francis B Stephens et al.
Clinical science (London, England : 1979), 127(5), 315-322 (2014-03-13)
Acylcarnitine accumulation in skeletal muscle and plasma has been observed in numerous models of mitochondrial lipid overload and insulin resistance. Fish oil n3PUFA (omega-3 polyunsaturated fatty acids) are thought to protect against lipid-induced insulin resistance. The present study tested the
Jacob Lorenzo-Morales et al.
Eukaryotic cell, 7(3), 509-517 (2008-01-29)
Acanthamoeba infections are difficult to treat due to often late diagnosis and the lack of effective and specific therapeutic agents. The most important reason for unsuccessful therapy seems to be the existence of a double-wall cyst stage that is highly
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