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Óttar Rolfsson et al.
The Biochemical journal, 449(2), 427-435 (2012-10-17)
Metabolic network reconstructions define metabolic information within a target organism and can therefore be used to address incomplete metabolic information. In the present study we used a computational approach to identify human metabolites whose metabolism is incomplete on the basis...
L Rajendran et al.
The Journal of membrane biology, 246(2), 121-129 (2012-11-03)
The mathematical model of Abdekhodaie and Wu (J Membr Sci 335:21-31, 2009) of glucose-responsive composite membranes for closed-loop insulin delivery is discussed. The glucose composite membrane contains nanoparticles of an anionic polymer, glucose oxidase and catalase embedded in a hydrophobic...
Rita Wegmüller et al.
The Journal of nutrition, 144(2), 132-136 (2013-11-22)
The water-soluble zinc salts gluconate, sulfate, and acetate are commonly used as supplements in tablet or syrup form to prevent zinc deficiency and to treat diarrhea in children in combination with oral rehydration. Zinc citrate is an alternative compound with...
Carole Poiraud et al.
European journal of dermatology : EJD, 22(5), 634-639 (2012-08-03)
Antimicrobial peptides (AMPs) are a large family of peptides implicated in innate immunity, especially in the epidermis. Zinc gluconate has been proven to be efficient to treat inflammatory dermatoses, such as acne vulgaris. The aim of our work was to...
Nehemiah Cox et al.
PloS one, 7(9), e45674-e45674 (2012-10-03)
Excessive NaCl intake is associated with a variety of fibrosing diseases such as renal and cardiac fibrosis. This association has been attributed to increased blood pressure as the result of high NaCl intake. However, studies in patients with high NaCl...
T Shigeta et al.
Transplantation proceedings, 44(4), 946-947 (2012-05-09)
Grafts from donation after cardiac death (DCD) will greatly contribute to the expand the donor pool. However, these grafts may require the development of the preservation methods because of primary nonfunction and severe ischemic bile duct injury. Porcine livers were...
Takanori Nihira et al.
FEBS letters, 587(21), 3556-3561 (2013-09-24)
A novel phosphorylase was characterized as new member of glycoside hydrolase family 94 from the cellulolytic bacterium Xanthomonas campestris and the fungus Neurospora crassa. The enzyme catalyzed reversible phosphorolysis of cellobionic acid. We propose 4-O-β-D-glucopyranosyl-D-gluconic acid: phosphate α-D-glucosyltransferase as the...
F Ru et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 27(6), 865-874 (2015-04-08)
Gastroesophageal reflux can cause high acidity in the esophagus and trigger heartburn and pain. However, because of the esophageal mucosal barrier, the acidity at the nerve terminals of pain-mediating C-fibers in esophageal mucosa is predicted to be substantially lower. We...
Tobias Klein et al.
Biotechnology and bioengineering, 110(2), 535-542 (2012-08-14)
Chemostat cultivation is a powerful tool for physiological studies of microorganisms. We report the construction and application of a set of eight parallel small-scale bioreactors with a working volume of 10 mL for continuous cultivation. Hungate tubes were used as culture...
Chang-Moon Lee et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 54(11), 1974-1980 (2013-09-21)
A new approach to the surface engineering of superparamagnetic iron oxide nanoparticles (SPIONs) may encourage their development for clinical use. In this study, we demonstrated that nonpolymeric surface modification of SPIONs has the potential to be an advanced biocompatible contrast...
Evaluation of intracellular pH regulation and alkalosis defense mechanisms in preimplantation embryos
Dagilgan S, et al.
Theriogenology, 83(6), 1075-1084 (2015)
Fiona Jasson et al.
Experimental dermatology, 22(9), 587-592 (2013-08-21)
Acne is a chronic inflammatory illness of the pilosebaceous follicle where innate immunity plays a central role. In acne, the density of Propionibacterium acnes is increased in the pilosebaceous unit. We hypothesized that the severity of acne is not only...
Jeffrey E Nowak et al.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 13(5), e323-e329 (2012-07-05)
We previously demonstrated that altered zinc homeostasis is an important feature of pediatric sepsis, thus raising the possibility of zinc supplementation as a therapeutic strategy in sepsis. Herein, we tested the hypothesis that prophylactic zinc supplementation would be beneficial in...
Yihang Li et al.
The Journal of nutrition, 144(12), 1935-1942 (2014-10-17)
Optimizing calcium nutrition to maximize bone accretion during growth to prevent fragility fractures later in life has spurred greater interest in calcium nutrition in neonates. The aim of this study was to determine the effect of dietary calcium, from deficiency...
Gluconic acid: Properties, applications and microbial production.
Ramachandran S, et al.
Food Technology and Biotechnology, 44(2), 185-195 (2006)
K Jagajjanani Rao et al.
ACS applied materials & interfaces, 7(25), 14018-14025 (2015-06-05)
The growing awareness toward the environment is increasing commercial demand for nanoparticles by green route syntheses. In this study, alloy-like Ag-Au-Pd trimetallic nanoparticles have been prepared by two plants extracts Aegle marmelos leaf (LE) and Syzygium aromaticum bud extracts (CE)....
Wei Ren et al.
Journal of pharmaceutical sciences, 103(6), 1692-1700 (2014-04-10)
Passive and iontophoretic transport of fluoride from three fluoride sources, NaF, sodium monofluorophosphate (MFP), and SnF2 solutions, across bovine enamel was investigated to (1) determine the characteristics of the intrinsic barrier of enamel for ion transport, (2) examine the feasibility...
Na Pang et al.
Bioresource technology, 288, 121525-121525 (2019-06-08)
Enhanced biosynthesis and overproduction of lipid and high-value bioproducts endows microalgae as a promising feedstock for the cost-effective development of advanced bioenergy currently. In this study, multilevel heuristic LED regimes, designed with the coordination of light, nitrogen and carbons in...
Julia Hasreiter et al.
American journal of physiology. Cell physiology, 306(12), C1200-C1213 (2014-04-25)
In the central nervous system, L-type voltage-gated calcium channels (LTCCs) come in two isoforms, namely Cav1.2 and Cav1.3 channels. It has been shown previously that these channels differ in biophysical properties, in subcellular localization, and in the coupling to the...
Michael T Rose et al.
Planta, 236(4), 959-973 (2012-04-25)
Plants are routinely subjected to multiple environmental stresses that constrain growth. Zinc (Zn) deficiency and high bicarbonate are two examples that co-occur in many soils used for rice production. Here, the utility of metabolomics in diagnosing the effect of each...
Anjana Gulani et al.
The Cochrane database of systematic reviews, 4(4), CD006639-CD006639 (2012-04-20)
Otitis media (OM) is inflammation of the middle ear and is usually caused by infection. It affects people of all ages but is particularly common in young children. Around 164 million people worldwide have long-term hearing loss caused by this...
Volker Behrends et al.
The Journal of biological chemistry, 288(21), 15098-15109 (2013-04-11)
Metabolic footprinting of supernatants has been proposed as a tool for assigning gene function. We used NMR spectroscopy to measure the exometabolome of 86 single-gene transposon insertion mutant strains (mutants from central carbon metabolism and regulatory mutants) of the opportunistic...
Serratia marcescens quinoprotein glucose dehydrogenase activity mediates medium acidification and inhibition of prodigiosin production by glucose.
Fender JE, et al.
Applied and Environmental Microbiology, AEM-01778 (2012)
Yanshun Xu et al.
Food chemistry, 134(2), 1005-1010 (2012-10-31)
The structural changes and aggregation properties of silver carp actomyosin acidified with d-gluconic acid-δ-lactone (GDL) were investigated. Results showed that silver carp actomyosin underwent aggregation and formation of precipitate as indicated by turbidity and centrifugation coupled electrophoresis analysis. Circular dichroism...
Erika C S Oliveira et al.
Animal reproduction science, 132(3-4), 207-212 (2012-06-12)
The objective was to determine whether the efficacy of zinc gluconate (Testoblock(®)) as a chemical contraceptive in male dogs was compromised in the presence of metamizole sodium (a nonsteroidal antiinflammatory/analgesic agent). Ten sexually mature mongrel dogs were assigned to two...
T Shigeta et al.
Transplantation proceedings, 44(4), 942-945 (2012-05-09)
The aims of this study were to compare extracellular and intracellular-type University of Wisconsin (UW) solutions for liver grafts and to assess oxygenation in this perfusion system. The organ preservation system consisted of 3 circulating systems for the portal vein...
Masataka Narukawa et al.
Bioscience, biotechnology, and biochemistry, 76(12), 2282-2288 (2012-12-12)
Gluconate is used as an additive in a wide range of processed foods. In this study, we investigated its utility as a taste-improving substance. To determine whether it has a suppressive effect on bitter taste, sensory evaluations were performed by...
Abdelali Daddaoua et al.
PloS one, 7(7), e39390-e39390 (2012-07-31)
Homologs of the transcriptional regulator PtxS are omnipresent in Pseudomonas, whereas PtxR homologues are exclusively found in human pathogenic Pseudomonas species. In all Pseudomonas sp., PtxS with 2-ketogluconate is the regulator of the gluconate degradation pathway and controls expression from...
Oleg A Nardid et al.
General physiology and biophysics, 32(1), 23-32 (2013-03-28)
Dimethyl sulfoxide (DMSO), a by-product of the pulping industry, is widely used in biological research, cryobiology and medicine. On cellular level DMSO was shown to suppress NMDA-AMPA channels activation, blocks Na+ channel activation and attenuates Ca2+ influx (Lu and Mattson...
Phenotyping sensory nerve endings in vitro in the mouse
Zimmermann K, et al.
Nature Protocols, 4(2), 174-196 (2009)
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