Showing 1-30 of 520 results for "G9023"
Jianjun Chang et al.
Cell biology and toxicology, 36(6), 571-589 (2020-06-27)
Smoke inhalation injury is the leading cause of death in firefighters and victims. Inhaled hot air and toxic smoke are the predominant hazards to the respiratory epithelium. We aimed to analyze the effects of thermal stress and smoke aldehyde on...
Rafal P Piprek et al.
Mechanisms of development, 147, 17-27 (2017-08-02)
Unlike other organ anlagens, the primordial gonad is sexually bipotential in all animals. In mouse, the bipotential gonad differentiates into testis or ovary depending on the genetic sex (XY or XX) of the fetus. During gonad development cells segregate, depending...
Shashank Rai et al.
Autophagy, 15(4), 599-612 (2018-11-08)
Macroautophagy/autophagy delivers damaged proteins and organelles to lysosomes for degradation, and plays important roles in maintaining tissue homeostasis by reducing tissue damage. The translocation of LC3 to the limiting membrane of the phagophore, the precursor to the autophagosome, during autophagy...
Thibault Teissier et al.
Aging cell, 18(2), e12850-e12850 (2019-02-23)
Pro-aging effects of endogenous advanced glycation end-products (AGEs) have been reported, and there is increasing interest in the pro-inflammatory and -fibrotic effects of their binding to RAGE (the main AGE receptor). The role of dietary AGEs in aging remains ill-defined...
Gonzalo Federico Mayol et al.
Biochimica et biophysica acta. Molecular cell research, 1867(1), 118566-118566 (2019-11-02)
Nuclear-cytoplasmic trafficking of proteins is a highly regulated process that modulates multiple biological processes in eukaryotic cells. In Giardia lamblia, shuttling has been described from the cytoplasm to nuclei of proteins during the biological cell cycle of the parasite. This...
Lyne Jossé et al.
Current protocols in microbiology, 53(1), e80-e80 (2019-02-09)
Cryptosporidium is a genus of ubiquitous unicellular parasites belonging to the phylum Apicomplexa. Cryptosporidium species are the second largest cause of childhood diarrhea and are associated with increased morbidity. Accompanying this is the low availability of treatment and lack of...
Lucas Oliveira Sousa et al.
Epigenomics, 12(6), 475-485 (2020-04-09)
Aim: Histone acetylation and methylation control gene expression. We investigated the impact of SET knockdown on histone methylation status and the consequences for the miRNAs levels in oral squamous cell carcinoma (OSCC). Methods: OSCC cells with and without SET knockdown...
Anielle L Gomes et al.
Frontiers in cell and developmental biology, 8, 711-711 (2020-08-28)
Genomic instability in the central nervous system (CNS) is associated with defective neurodevelopment and neurodegeneration. Congenital human syndromes that affect the CNS development originate from mutations in genes of the DNA damage response (DDR) pathways. RINT1 (Rad50-interacting protein 1) is...
Valentina Bouché et al.
Autophagy, 12(3), 484-498 (2016-01-14)
An evolutionarily conserved gene network regulates the expression of genes involved in lysosome biogenesis, autophagy, and lipid metabolism. In mammals, TFEB and other members of the MiTF-TFE family of transcription factors control this network. Here we report that the lysosomal-autophagy...
Nélia Varela et al.
PLoS biology, 17(1), e2006749-e2006749 (2019-01-18)
In flies, the olfactory information is carried from the first relay in the brain, the antennal lobe, to the mushroom body (MB) and the lateral horn (LH). Olfactory associations are formed in the MB. The LH was ascribed a role...
Benjamin W Lindsey et al.
Frontiers in neuroscience, 11, 750-750 (2018-02-02)
The field of macro-imaging has grown considerably with the appearance of innovative clearing methods and confocal microscopes with lasers capable of penetrating increasing tissue depths. The ability to visualize and model the growth of whole organs as they develop from...
Tess Torregrosa et al.
Journal of neuroscience methods, 341, 108724-108724 (2020-05-20)
Generally, primary neurons are isolated and seeded within hours of isolation, but cryopreservation, documented for a small number of central and peripheral neuronal subtypes, can contribute to improved utility and reduce the cost of developing new in vitro models. The...
Dinorath Olvera et al.
Acta biomaterialia, 64, 148-160 (2017-10-12)
The ideal tissue engineering (TE) strategy for ligament regeneration should recapitulate the bone - calcified cartilage - fibrocartilage - soft tissue interface. Aligned electrospun-fibers have been shown to guide the deposition of a highly organized extracellular matrix (ECM) necessary for...
J D Neves et al.
Brain research bulletin, 134, 55-62 (2017-07-15)
Striatum and the cerebral cortex are regions susceptible to secondary injury after intracerebral hemorrhage (ICH) and glial cells in tissue adjacent to the hematoma may modulate cellular vulnerability after brain damage. Nonetheless, while the glial- associated changes occurring in the...
Lorena Armijo-Weingart et al.
eLife, 8 (2019-12-04)
Neurotrophins are growth factors that have a multitude of roles in the nervous system. We report that neurotrophins induce the fission of mitochondria along embryonic chick sensory axons driven by combined PI3K and Mek-Erk signaling. Following an initial burst of...
Michael J Mosca et al.
BMJ open sport & exercise medicine, 3(1), e000225-e000225 (2017-08-02)
Alarmins, endogenous molecules released on tissue damage have been shown to play an important role in inflammatory musculoskeletal conditions including fracture repair andrheumatoid arthritis. However, the contribution of alarmins to the pathogenesis of tendon disease is not fully understood. We...
Ala Morshedian et al.
Neuron, 102(6), 1172-1183 (2019-05-06)
While rods in the mammalian retina regenerate rhodopsin through a well-characterized pathway in cells of the retinal pigment epithelium (RPE), cone visual pigments are thought to regenerate in part through an additional pathway in Müller cells of the neural retina....
Min Sik Choi et al.
Journal of lipid research, 57(4), 607-615 (2016-02-07)
NO regulates a variety of physiological processes, including cell proliferation, differentiation, and inflammation. S-nitrosylation, a NO-mediated reversible protein modification, leads to changes in the activity and function of proteins. In particular, the role of S-nitrosylation during adipogenesis is largely unknown....
Takaaki Daimon et al.
Current biology : CB, 31(4), 884-891 (2020-12-15)
Animals with exoskeletons molt for further growth. In insects, the number of larval (or nymphal) molts varies inter- and intra-specifically, and it is widely accepted that the variation in the number of larval molts is an adaptive response to diverse...
Mayumi Machida et al.
Sleep, 40(4) (2017-02-16)
Stressful events can directly produce significant alterations in subsequent sleep, in particular rapid eye movement sleep (REM); however, the neural mechanisms underlying the process are not fully known. Here, we investigated the role of the basolateral nuclei of the amygdala...
Tatsuo S Okubo et al.
Neuron, 107(5), 924-940 (2020-07-19)
Spatial maps in the brain are most accurate when they are linked to external sensory cues. Here, we show that the compass in the Drosophila brain is linked to the direction of the wind. Shifting the wind rightward rotates the...
Savannah A Lynn et al.
F1000Research, 7, 1107-1107 (2018-10-03)
The retinal pigment epithelium (RPE) plays a key role in the pathogenesis of several blinding retinopathies. Alterations to RPE structure and function are reported in Age-related Macular Degeneration, Stargardt and Best disease as well as pattern dystrophies. However, the precise...
Yueguang Wei et al.
Molecular medicine reports, 17(2), 2600-2606 (2017-12-06)
Long non‑coding RNA (lncRNA) H19 has been suggested to serve important roles in the progression of gastric cancer (GC); however, the mechanism involved is largely unknown. The present study aimed to investigate the mechanism underlying the effect of H19 on...
Sebastian Dupraz et al.
Current biology : CB, 29(22), 3874-3886 (2019-11-05)
The specification of an axon and its subsequent outgrowth are key steps during neuronal polarization, a prerequisite to wire the brain. The Rho-guanosine triphosphatase (GTPase) RhoA is believed to be a central player in these processes. However, its physiological role...
Sandeep Kumar et al.
PloS one, 12(7), e0181235-e0181235 (2017-07-28)
Hypoxia is known to induce pancreatic beta cell dysfunction and apoptosis. Changes in Programmed Cell Death Gene 4 (PDCD4) expression have previously been linked with beta cell neogenesis and function. Our aim was to investigate the effects of hypoxia on...
Héctor Carreño Gutiérrez et al.
Scientific reports, 9(1), 3040-3040 (2019-03-01)
The formation of social groups is an adaptive behaviour that can provide protection from predators, improve foraging and facilitate social learning. However, the costs of proximity can include competition for resources, aggression and kleptoparasitism meaning that the decision whether to...
Bo Ding et al.
Hearing research, 367, 59-73 (2018-07-22)
Due to the critical role of cochlear ion channels for hearing, the focus of the present study was to examine age-related changes of Na, K-ATPase (NKA) subunits in the lateral wall of mouse cochlea. We combined qRT-PCR, western blot and...
Britney O Pennington et al.
Stem cells translational medicine, 4(2), 165-177 (2015-01-17)
Age-related macular degeneration (AMD), a leading cause of blindness, is characterized by the death of the retinal pigmented epithelium (RPE), which is a monolayer posterior to the retina that supports the photoreceptors. Human embryonic stem cells (hESCs) can generate an...

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