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Downregulation of oxytocin receptors in right ventricle of rats with monocrotaline-induced pulmonary hypertension.
Broderick, T.L., et al.
Acta Physiol., 200, 147-158 (2010)
Sung Young Park et al.
RNA (New York, N.Y.), 26(1), 101-109 (2019-10-24)
The MS2 system, with an MS2 binding site (MBS) and an MS2 coat protein fused to a fluorescent protein (MCP-FP), has been widely used to fluorescently label mRNA in live cells. However, one of its limitations is the constant background
Jesús Gómez-Escudero et al.
Scientific reports, 9(1), 15022-15022 (2019-10-23)
Angiogenesis, the formation of new blood vessels from pre-existing ones, occurs in pathophysiological contexts such as wound healing, cancer, and chronic inflammatory disease. During sprouting angiogenesis, endothelial tip and stalk cells coordinately remodel their cell-cell junctions to allow collective migration
Huiying Yu et al.
Experimental and therapeutic medicine, 14(6), 5678-5686 (2017-12-30)
Cell-based adoptive immunotherapy for the treatment of various cancer types has attracted the attention of scientists. However, due to the absence of unitary standard protocols to produce large quantities of clinical-grade effector cells, it remains challenging to translate the experimental
Elliot P Tague et al.
Nature methods, 15(7), 519-522 (2018-07-04)
We developed a method in which the NS3 cis-protease from hepatitis C virus can be used as a ligand-inducible connection to control the function and localization of engineered proteins in mammalian cells. To demonstrate the versatility of this approach, we
Christopher A Werley et al.
Nature communications, 11(1), 3881-3881 (2020-08-06)
Cells typically respond to chemical or physical perturbations via complex signaling cascades which can simultaneously affect multiple physiological parameters, such as membrane voltage, calcium, pH, and redox potential. Protein-based fluorescent sensors can report many of these parameters, but spectral overlap
Colin H Beckwitt et al.
British journal of cancer, 119(9), 1094-1105 (2018-11-08)
Metastasis in breast cancer foreshadows mortality, as clinically evident disease is aggressive and generally chemoresistant. Disseminated breast cancer cells often enter a period of dormancy for years to decades before they emerge as detectable cancers. Harboring of these dormant cells
Anna Burdzinska et al.
Anatomical record (Hoboken, N.J. : 2007), 300(3), 577-588 (2016-10-16)
Cell therapy is emerging as an alternative treatment of stress urinary incontinence. However, many aspects of the procedure require further optimization. A large animal model is needed to reliably test cell delivery methods. In this study, we aim to determine
Chengxian Xu et al.
Journal of immunology (Baltimore, Md. : 1950), 200(1), 271-285 (2017-11-24)
In mammalian cells, signaling pathways triggered by TNF can be switched from NF-κB activation to apoptosis and/or necroptosis. The in vivo mechanisms underlying the mutual regulation of these three signaling pathways are poorly understood. In this article, we report that
Yuxian Song et al.
Cancer biology & therapy, 15(10), 1423-1430 (2014-07-22)
MicroRNAs (miRNAs) dysregulation is critically involved in lung cancer. Regulating miRNAs by natural agents may be a new strategy for cancer treatment. We previously found that a novel small-molecule compound diaporine A (D261), a natural product of endophytic fungus 3lp-10
Sarah Colijn et al.
Cell death and differentiation, 27(2), 618-631 (2019-06-27)
Physiological hypoxia can trigger transcriptional events that influence many developmental processes during mammalian embryogenesis. One way that hypoxia affects transcription is by engaging chromatin-remodeling complexes. We now report that chromodomain helicase DNA binding protein 4 (CHD4), an enzyme belonging to
Xiao Yang et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 30(2), 601-611 (2015-10-08)
Endothelial activation is a hallmark of the high-glucose (HG)-induced retinal inflammation associated with diabetic retinopathy (DR). However, precisely how HG induces retinal endothelial activation is not fully understood. We hypothesized that HG-induced up-regulation of lysyl oxidase (LOX), a collagen-cross-linking enzyme
A Joshi et al.
Cell death and differentiation, 23(2), 216-230 (2015-07-04)
Reactive oxygen species (ROS) may cause cellular damage and oxidative stress-induced cell death. Autophagy, an evolutionarily conserved intracellular catabolic process, is executed by autophagy (ATG) proteins, including the autophagy initiation kinase Unc-51-like kinase (ULK1)/ATG1. Although autophagy has been implicated to
Hai-Yan Song et al.
Experimental and therapeutic medicine, 16(1), 53-60 (2018-06-14)
Pancreatic cancer is the fourth leading cause of cancer-associated mortality in developed countries. Pancreatic ductal adenocarcinoma (PDAC) accounts for ~90% of all pancreatic cancer cases. The Notch signaling pathway serves a crucial role in embryonic development, as well as during
Frazer P Coutinho et al.
Scientific reports, 8(1), 11256-11256 (2018-07-28)
The current study investigated the use of two cationic peptides, Xentry-KALA (XK) and Xentry-Protamine (XP), for intracellular delivery of Connexin43 antisense oligonucleotides (Cx43AsODN). The charge and size of Cx43AsODN:XK and Cx43AsODN:XP complexes was determined by Zetasizer analysis. The earliest positive
Nicole Hustedt et al.
Genes & development, 33(19-20), 1397-1415 (2019-08-31)
DNA repair by homologous recombination (HR) is essential for genomic integrity, tumor suppression, and the formation of gametes. HR uses DNA synthesis to repair lesions such as DNA double-strand breaks and stalled DNA replication forks, but despite having a good
The microRNA miR-134-5p induces calcium deposition by inhibiting histone deacetylase 5 in vascular smooth muscle cells.
Choe, et al.
Journal of Cellular and Molecular Medicine, 24, 10542-10550 (2021)
Kousho Wakae et al.
Scientific reports, 8(1), 9745-9745 (2018-06-29)
Mitochondrial DNA (mtDNA) mutations are found in many types of cancers and suspected to be involved in carcinogenesis, although the mechanism has not been elucidated. In this study, we report that consecutive C-to-T mutations (hypermutations), a unique feature of mutations
Jesús Duque-Afonso et al.
Cancer research, 78(22), 6497-6508 (2018-09-29)
Dasatinib is a multi-tyrosine kinase inhibitor approved for treatment of Ph+ acute lymphoblastic leukemia (ALL), but its efficacy is limited by resistance. Recent preclinical studies suggest that dasatinib may be a candidate therapy in additional ALL subtypes including pre-BCR+ ALL.
Naoko Kikkawa et al.
International journal of oncology, 44(6), 2085-2092 (2014-03-22)
Our recent study of the microRNA (miRNA) expression signature of hypopharyngeal squamous cell carcinoma (HSCC) revealed that microRNA-504 (miR-504) is significantly downregulated in HSCC tissues, suggesting that this miRNA is a candidate tumor suppressor. However, several previous reports indicated that
Liping Wang et al.
Frontiers in molecular biosciences, 8, 687305-687305 (2021-11-23)
Few studies have reported whether nutrients in the tumor microenvironment can regulate the expression of PD-L1. Since tumor cells are often situated in a low-glutamine environment, we investigated PD-L1 expression under glutamine deprivation in bladder cancer cells. PD-L1 expression and
Jonas Feuge et al.
Cerebral cortex (New York, N.Y. : 1991), 29(12), 5204-5216 (2019-04-07)
Multiple variants of intellectual disability, e.g., the Fragile X Syndrome are associated with alterations in dendritic spine morphology, thereby pointing to dysregulated actin dynamics during development and processes of synaptic plasticity. Surprisingly, although the necessity of spine actin remodeling was
Libi Anandi et al.
Journal of cell science, 130(21), 3749-3763 (2017-09-20)
DNA alkylating agents form the first line of cancer chemotherapy. They not only kill cells but also behave as potential carcinogens. MNU, a DNA methylating agent, is well known to induce mammary tumours in rodents. However, the mechanism of tumorigenesis
Hong Li et al.
Neurobiology of disease, 54, 216-224 (2013-01-15)
Application of isoflurane, a volatile anesthetic, after brain ischemia can reduce ischemic brain injury in rodents (isoflurane postconditioning). This study is designed to determine whether isoflurane postconditioning improves long-term neurological outcome after focal brain ischemia and whether this protection is
Biserka Relic et al.
Oncotarget, 9(88), 35830-35843 (2018-12-12)
Phosphorylation of p62/SQSTM1 (p62) on Serine 349 (P-Ser349 p62) as well as proteasome dysfunction have been shown to activate the cell protective Keap1/Nrf2 pathway. We showed previously that BAY 11-7085-induced human synovial fibroblast cell death includes autophagy and p62 downregulation.
Marilyn Parra et al.
RNA (New York, N.Y.), 26(8), 996-1005 (2020-04-22)
The decoy exon model has been proposed to regulate a subset of intron retention (IR) events involving predominantly larger introns (>1 kb). Splicing reporter studies have shown that decoy splice sites are essential for activity, suggesting that decoys act by
Christopher J Nicholson et al.
Journal of cellular and molecular medicine, 21(1), 81-95 (2016-08-10)
Increased aortic stiffness is a biomarker for subsequent adverse cardiovascular events. We have previously reported that vascular smooth muscle Src-dependent cytoskeletal remodelling, which contributes to aortic plasticity, is impaired with ageing. Here, we use a multi-scale approach to determine the
Andrea Fernanda Gil Lorenzo et al.
Cell stress & chaperones, 19(1), 115-134 (2013-06-14)
A series of signaling cascades are activated after angiotensin II binds to angiotensin II type I receptor (AT1R), a peptide that is an important mediator of oxidative stress. Hsp70 regulates a diverse set of signaling pathways through interactions with proteins.
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