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Showing 1-30 of 52 results for "ganoderic acids" within Papers
Jia Meng et al.
Acta pharmacologica Sinica, 41(6), 782-790 (2020-01-09)
Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common life-threatening monogenetic diseases characterized by progressive enlargement of fluid-filled renal cysts. Our previous study has shown that Ganoderma triterpenes (GT) retards PKD renal cyst development. In the present
Xu Lixin et al.
Journal of biochemical and molecular toxicology, 33(4), e22271-e22271 (2018-12-07)
This study clarified the protective effect of ganoderic acid A (GAA) on cyclophosphamide (CP)-induced hepatotoxicity in mice. Hepatic injury mice were induced by a single intraperitoneal injection of CP (200 mg/kg). The results showed that the levels of alanine aminotransferase (ALT)
Yue Jia et al.
Neurochemical research, 46(7), 1725-1736 (2021-04-07)
Neuroinflammation plays an important role in the onset and progression of neurodegenerative diseases. Microglia-mediated neuroinflammation have been proved to be the main reason for causing the neurodegenerative diseases. Ganoderic acid A (GAA), isolated from Ganoderma lucidum, showed anti-inflammatory effect in
Jia-Long Tian et al.
Fungal genetics and biology : FG & B, 130, 19-30 (2019-04-28)
Hydrogen sulfide (H2S), an emerging small-molecule signalling agent, was recently shown to play a significant role in many physiological processes, but relatively few studies have been conducted on microorganisms compared with mammals and plants. By studying the pretreatment of H2S
Jing Zhu et al.
Chemico-biological interactions, 290, 77-87 (2018-06-01)
Obesity and its major co-morbidity, type 2 diabetes, have been an alarming epidemic prevalence without an effective treatment available. Sterol regulatory element-binding proteins (SREBPs) are major transcription factors regulating the expression of genes involved in biosynthesis of cholesterol, fatty acid
Ai-Liang Jiang et al.
International journal of molecular sciences, 20(24) (2019-12-11)
Ganoderma lucidum is widely recognized as a medicinal basidiomycete. It was previously reported that the plant hormone methyl jasmonate (MeJA) could induce the biosynthesis of ganoderic acids (GAs), which are the main active ingredients of G. lucidum. However, the regulatory
A Das et al.
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 22(7), 1138-1145 (2019-11-17)
N-myc downstream-regulated gene 2 (NDRG2) is down-regulated in grade-III meningioma [anaplastic meningioma (AM)] and associated with clinically aggressive behavior. Current therapies in the treatment of high-grade meningioma are lacking with limited success. This study aims to validate the effect of
Baojin Chi et al.
Experimental and therapeutic medicine, 15(1), 847-853 (2018-02-06)
For several thousand years
Li-Feng-Rong Qi et al.
International journal of molecular sciences, 22(11) (2021-06-03)
Alzheimer's disease (AD) is thought to be caused by amyloid-β (Aβ) accumulation in the central nervous system due to deficient clearance. The aim of the present study was to investigate the effect of ganoderic acid A (GAA) on Aβ clearance
Fang-Rui Cao et al.
Frontiers in pharmacology, 8, 101-101 (2017-03-23)
Ganoderic acid A (GAA), a representative active triterpenoid from
Tan Gao et al.
Applied and environmental microbiology, 84(13) (2018-04-22)
Ganoderma lucidum is among the best known medicinal basidiomycetes due to its production of many pharmacologically active compounds. To study the regulatory networks involved in its growth and development, we analyzed the relationship between reactive oxygen species (ROS) and Ca2+
Feiya Sheng et al.
Nutrients, 12(1) (2020-01-02)
Microglia mediated neuronal inflammation has been widely reported to be responsible for neurodegenerative disease. Deacetyl ganoderic acid F (DeGA F) is a triterpenoid isolated from Ganoderma lucidum, which is a famous edible and medicinal mushroom used for treatment of dizziness
Zhendong Liu et al.
European journal of pharmacology, 824, 72-77 (2018-01-29)
Ganoderic acid D (GAD) is a highly oxygenated tetracyclic triterpenoid. This study aims to assess the effects of GAD on the energy metabolism of colon cancer through the regulation of SIRT3 expression and whether this effect is related to acetylated
Hong Li et al.
Phytotherapy research : PTR, 34(3), 640-648 (2019-11-20)
Ganoderic Acid A (GAA) is often applied for healing cardiovascular and cerebrovascular ailments, but the influences in cerebral ischemia injury are still hazy. The research delved into the functions of GAA in hypoxia-triggered impairment in PC12 cells. PC12 cells received
Yanhua Chang et al.
Phytotherapy research : PTR, 33(5), 1448-1456 (2019-03-07)
Effects of ganoderic acid A (GAA), a lanostane triterpene, on hypoxia-ischemia encephalopathy (HIE) remain unclear. We aimed to figure out the specific role of GAA in hypoxia-treated neural stem cells (NSCs) as well as the regulatory mechanisms. Primary rat NSCs
Ru-Ming Liu et al.
Chemico-biological interactions, 240, 134-144 (2015-08-19)
Ganoderic acids (GAs) produced by Ganoderma lucidum possess anticancer activities with the generation of reactive oxygen species (ROS). However, the role of oxidative stress in apoptotic process induced by GAs is still undefined. In this study, the effects of four
Chang-Sheng Shao et al.
Journal of ethnopharmacology, 262, 113213-113213 (2020-08-07)
Ganoderma lucidum has been used as a medicinal mushroom for more than 2000 years in China. Ganoderic acid D (GAD) as a representative active triterpenoid from Ganoderma lucidum is known to possess anticancer activity. However, the mechanism involved in its
Junbo Xia et al.
Chemico-biological interactions, 316, 108932-108932 (2019-12-25)
The incidence and mortality of lung cancer are the highest among cancer-related deaths. However, the long-term use of currently available cytotoxic drugs can increase genetic alterations in cancer cells and cause drug-resistance, which significantly limits their usage. Since current systemic
Xiaohong Zhang et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 50(6), 2086-2096 (2018-11-12)
Ganoderic acid A (GAA) isolated from Ganoderma lucidum, shows various benefit activities, such as anti-tumor activity, anti-HIV activity and hepatoprotective activity. However, the potential effects of GAA on hypoxia-induced injury of cardiomyocytes are still unclear. In this study, we aimed
Ling Zhang et al.
Neuropsychiatric disease and treatment, 17, 2671-2681 (2021-08-24)
Post-stroke depression (PSD) is a common complication after stroke. Ganoderic acid A (GAA), one of the main bioactive Ganoderma triterpenoids, exerts preventive and therapeutic effects in many diseases. However, the function of GAA in PSD has not been well studied.
Gorawit Yusakul et al.
Biological & pharmaceutical bulletin, 40(10), 1767-1774 (2017-10-03)
Due to the highly specific binding between an antibody and its target, superior analytical performances was obtained by immunoassays for phytochemical analysis over conventional chromatographic techniques. Here, we describe a simple method for producing a functional single-chain variable fragment (scFv)
Ruo-Lin Zhao et al.
Journal of ethnopharmacology, 210, 287-295 (2017-09-09)
Ganoderma lucidum (GL) is an oriental medical fungus, which was used to prevent and treat many diseases. Previously, the effective compounds of Ganoderma lucidum extract (GLE) were extracted from two kinds of GL, [Ganoderma lucidum (Leyss. Ex Fr.) Karst.] and
Yuguang Yang et al.
Oncology letters, 16(5), 6515-6521 (2018-11-09)
Breast cancer is a common malignant tumor among females, with triple-negative breast cancer being an important type accounting for 15-20% of all breast cancer cases. Triple-negative breast cancer is one of the most aggressive types of cancer without standard adjuvant
Hanan M Hassan et al.
Drug design, development and therapy, 14, 2335-2353 (2020-07-02)
Drug-induced liver injury (DILI) is the most common cause of acute liver failure. The aim of this study was to investigate the molecular mechanisms by which Ganoderma lucidum mushroom (GLM) may ameliorate cisplatin (CP)-induced hepatotoxicity theoretically and experimentally. Thirty-six male
Na Feng et al.
Biomedical chromatography : BMC, 32(10), e4283-e4283 (2018-05-12)
Ganoderic acid S, ganoderic acid T and ganoderal B are the main bioactive triterpenes of Ganoderma lucidum. In this study, mycelia of G. lucidum were obtained by two-stage fermentation and then extracted by ethanol and petroleum ether sequentially to obtain
Jie Liu et al.
Bioorganic & medicinal chemistry letters, 19(8), 2154-2157 (2009-03-18)
Prostate cancer is the most common cancer in men in Western countries, with a high incidence of bone metastasis. Ganoderic acid DM, with 5alpha-reductase inhibitory and androgen receptor (AR) binding activity, isolated from the ethanol extracts of Ganoderma lucidum, can
Bang-Jau You et al.
Bioscience, biotechnology, and biochemistry, 76(8), 1529-1534 (2012-08-11)
Submerged cultures of Ganoderma lucidum are used to produce fungal mycelium, which is used as a functional food and in the production of various triterpenoids, including ganoderic acids (GAs). Specific culture approaches that produce fungal mycelium with high levels of
Jiang Shi et al.
International immunopharmacology, 88, 106990-106990 (2020-11-14)
Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a serious respiratory disease, the mechanism is unclear. This paper revealed the mechanism of ganoderic acid B (BB) on lipopolysaccharide-induced pneumonia in mice. Pneumonia model was induced by LPS in mice
Xiangyang Yao et al.
Planta medica, 78(16), 1740-1748 (2012-09-11)
Ganoderic acid A is a lanostane triterpene isolated from Ganoderma lucidum. It has been reported to exhibit antitumor activity, which is mainly mediated through its inhibitory effect on nuclear transcription factor-kappaB and activator protein-1. But the role of ganoderic acid
Xu Wang et al.
Molecular medicine reports, 16(4), 3894-3900 (2017-07-22)
Ganoderic acid A (GA‑A), a triterpenoid, has been demonstrated to suppress cell proliferation in various cancers, including breast cancer and osteosarcoma. However, its effect on human hepatocellular carcinoma (HCC) remains to be elucidated. The present study aimed to investigate the
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