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Showing 1-29 of 29 results for "GF53688415" within Papers
Amy Ekechukwu et al.
Journal of occupational and environmental hygiene, 6(12), 766-774 (2009-11-07)
This document provides a listing of available sources that can be used to validate analytical methods and/or instrumentation for beryllium determination. A literature review was conducted of available standard methods and publications used for method validation and/or quality control. An
Shaodong Dai et al.
Current opinion in immunology, 25(6), 775-780 (2013-08-28)
Chronic beryllium disease (CBD) is a granulomatous lung disorder caused by a hypersensitivity to beryllium and characterized by the accumulation of beryllium-specific CD4(+) T cells in the lung. Genetic susceptibility to beryllium-induced disease is strongly associated with HLA-DP alleles possessing
Martin Harper
Journal of environmental monitoring : JEM, 8(6), 598-604 (2006-06-13)
Standardized conventions governing the fractions of airborne particles that can penetrate the human head airways, the thoracic airways and the alveolar spaces have been internationally (although not universally) adopted. Several agencies involved in setting limit values for occupational exposure concentrations
Gina M Clayton et al.
Cell, 158(1), 132-142 (2014-07-06)
T-cell-mediated hypersensitivity to metal cations is common in humans. How the T cell antigen receptor (TCR) recognizes these cations bound to a major histocompatibility complex (MHC) protein and self-peptide is unknown. Individuals carrying the MHCII allele, HLA-DP2, are at risk
Paolo Boffetta et al.
Critical reviews in toxicology, 42(2), 107-118 (2012-01-27)
There is controversy on whether occupational exposure to beryllium causes lung cancer. We conducted a systematic review of epidemiologic studies on cancer among workers exposed to beryllium, including a study of seven U.S. production plants which has been recently updated
Massimo Amicosante et al.
Clinical immunology (Orlando, Fla.), 121(2), 134-143 (2006-05-16)
Chronic beryllium disease (CBD) is a granulomatous lung disorder caused by beryllium exposure in the workplace and is characterized by the accumulation of beryllium-specific CD4(+) T cells. Depending on genetic susceptibility and the nature of the exposure, CBD occurs in
Rebecca M Hine et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 307(7), R837-R849 (2014-07-25)
The handling of Na(+) and K(+) loads was investigated in isolated Malpighian tubules and in whole mosquitoes of Aedes aegypti. Isolated Malpighian tubules bathed in Na(+)-rich Ringer solution secreted Na(+)-rich fluid, and tubules bathed in K(+)-rich Ringer solution secreted K(+)-rich
Erin Shay et al.
Critical reviews in toxicology, 43(3), 220-243 (2013-03-01)
The exposure-response patterns with beryllium sensitization (BeS), chronic beryllium disease (CBD) and lung cancer are influenced by a number of biological and physicochemical factors. Recent studies have suggested dermal exposure as a pathway for BeS. In light of the current
Kathleen Kreiss et al.
Annual review of public health, 28, 259-277 (2006-11-11)
Beryllium exposure can cause a granulomatous lung disease in workers who develop a lymphocyte-mediated sensitization to the metal. Workers in diverse industries are at risk because beryllium's properties are critical to nuclear, aerospace, telecommunications, electronic, metal alloy, biomedical, and semiconductor
K D Rosenman et al.
Occupational and environmental medicine, 68(7), 487-493 (2010-12-28)
Chronic beryllium disease (CBD) is a hypersensitivity granulomatous pulmonary disease caused by exposure to the metal beryllium (Be²⁺). Our objective was to extend current knowledge of the genetics of beryllium disease by examining all HLA-DPB1 and HLA-DPR1 gene polymorphisms and
Dan Middleton et al.
International journal of environmental research and public health, 7(1), 115-124 (2010-03-03)
Beryllium is a lightweight metal with unique qualities related to stiffness, corrosion resistance, and conductivity. While there are many useful applications, researchers in the 1930s and 1940s linked beryllium exposure to a progressive occupational lung disease. Acute beryllium disease is
Michael T Falta et al.
Proceedings of the American Thoracic Society, 7(2), 126-129 (2010-04-30)
Chronic beryllium disease (CBD) is a granulomatous lung disorder caused by beryllium (Be) exposure in the workplace. It is characterized by the accumulation of Be-specific CD4(+) T cells in the lung as well as persistent lung inflammation, culminating in the
Michael J Brisson et al.
Journal of environmental monitoring : JEM, 8(6), 605-611 (2006-06-13)
Control of workplace exposure to beryllium is a growing issue in the United States and other nations. As the health risks associated with low-level exposure to beryllium are better understood, the need increases for improved analytical techniques both in the
L Mangin-Thro et al.
Nature communications, 6, 7705-7705 (2015-07-04)
The pseudo-gap phenomenon in copper oxide superconductors is central to any description of these materials as it prefigures the superconducting state itself. A magnetic intra-unit-cell order was found to occur just at the pseudo-gap temperature in four cuprate high-Tc superconducting
Elijah Thimsen et al.
Nature communications, 5, 5822-5822 (2014-12-20)
Thin films comprising semiconductor nanocrystals are emerging for applications in electronic and optoelectronic devices including light emitting diodes and solar cells. Achieving high charge carrier mobility in these films requires the identification and elimination of electronic traps on the nanocrystal
Brian C Tooker et al.
Journal of immunotoxicology, 12(2), 181-187 (2014-06-17)
Exposure to small amounts of beryllium (Be) can result in beryllium sensitization and progression to Chronic Beryllium Disease (CBD). In CBD, beryllium is presented to Be-responsive T-cells by professional antigen-presenting cells (APC). This presentation drives T-cell proliferation and pro-inflammatory cytokine
V Jomelli et al.
Nature, 513(7517), 224-228 (2014-08-27)
The Younger Dryas stadial, a cold event spanning 12,800 to 11,500 years ago, during the last deglaciation, is thought to coincide with the last major glacial re-advance in the tropical Andes. This interpretation relies mainly on cosmic-ray exposure dating of glacial
Peng Ge et al.
Nature structural & molecular biology, 21(12), 1075-1081 (2014-11-05)
Essential cellular processes involving the actin cytoskeleton are regulated by auxiliary proteins that can sense the nucleotide state of actin. Here we report cryo-EM structures for ADP-bound and ADP-beryllium fluoride (ADP-BeFx, an ADP-Pi mimic)-bound actin filaments in complex with the
D M Hollins et al.
Critical reviews in toxicology, 39 Suppl 1, 1-32 (2009-11-13)
The potential carcinogenicity of beryllium has been a topic of study since the mid-1940s. Since then, numerous scientific and regulatory bodies have assigned beryllium to various categories with respect to its carcinogenicity. Past epidemiologic and animal studies, however, have been
Darrah K Sleeth
Environmental science. Processes & impacts, 15(5), 898-903 (2013-04-12)
In 2010, the American Conference of Governmental Industrial Hygienists (ACGIH) formally changed its Threshold Limit Value (TLV) for beryllium from a 'total' particulate sample to an inhalable particulate sample. This change may have important implications for workplace air sampling of
T Mark McCleskey et al.
Journal of occupational and environmental hygiene, 6(12), 751-757 (2009-11-07)
We compare beryllium to H+ and show that beryllium can displace H+ in many "strong hydrogen bonds" where Be as a "tetrahedral proton" (O-Be-O angle is tetrahedral as opposed to the nearly linear O-H-O angle) is thermodynamically preferred. The strong
Richard T Sawyer et al.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 24(1), 1-17 (2010-10-29)
During the last decade, there have been concerted efforts to reduce beryllium (Be) exposure in the workplace and thereby reduce potential cases of this occupational lung disorder. Despite these efforts, it is estimated that there are at least one million
John R Balmes et al.
American journal of respiratory and critical care medicine, 190(10), e34-e59 (2014-11-15)
Beryllium continues to have a wide range of industrial applications. Exposure to beryllium can lead to sensitization (BeS) and chronic beryllium disease (CBD). The purpose of this statement is to increase awareness and knowledge about beryllium exposure, BeS, and CBD.
T Mark McCleskey et al.
Reviews on environmental health, 24(2), 75-115 (2009-08-08)
In this review we summarize the work conducted over the past decade that has advanced our knowledge of pulmonary diseases associated with exposure to beryllium that has provided a molecular-based understanding of the chemistry, immunopathology, and immunogenetics of beryllium toxicity.
Christian Strupp
The Annals of occupational hygiene, 55(1), 43-56 (2011-01-05)
Beryllium metal was classified in Europe collectively with beryllium compounds, e.g. soluble salts. Toxicological equivalence was assumed despite greatly differing physicochemical properties. Following introduction of the Registration, Evaluation, Authorization and Restriction of Chemicals (REACH) regulation, beryllium metal was classified as
Linus H Santo Tomas
Current opinion in pulmonary medicine, 15(2), 165-169 (2009-06-18)
This review aims to present the clinician with a synthesis of recent studies that have enhanced our understanding of the epidemiology and pathogenesis of beryllium hypersensitivity (BeH) and chronic beryllium disease (CBD). Lower occupational limit levels to beryllium exposure and
Nicola Cherry et al.
Occupational and environmental medicine, 72(1), 21-27 (2014-10-12)
The study was designed to investigate whether beryllium exposure was related to illness diagnosed as sarcoidosis. Chronic beryllium disease (CBD) and sarcoidosis are clinically and pathologically indistinguishable, with only the presence of beryllium-specific T-lymphocytes identifying CBD. Testing for such cells
A Seidler et al.
Occupational medicine (Oxford, England), 62(7), 506-513 (2012-06-19)
The relevance of beryllium sensitization testing for occupational health practice and prevention is unclear. To analyse the natural course of beryllium sensitization and clarify the prognosis following cessation of exposure among sensitized workers. An electronic literature search was conducted in
Kristin J Cummings et al.
Environmental health perspectives, 117(8), 1250-1256 (2009-08-13)
Although chronic beryllium disease (CBD) is clearly an immune-mediated granulomatous reaction to beryllium, acute beryllium disease (ABD) is commonly considered an irritative chemical phenomenon related to high exposures. Given reported new cases of ABD and projected increased demand for beryllium
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