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Annukka M Kallinen et al.
Molecular pharmaceutics, 11(8), 2876-2886 (2014-07-01)
The use of nanoparticle carriers for the sustained release of cytotoxic drugs in cancer therapy can result in fewer adverse effects and can thus be of great benefit for the patient. Recently, a novel nanocomposite, prepared by the encapsulation of
Yu-Jin Hwang et al.
Nutrients, 6(7), 2956-2972 (2014-07-25)
Excess accumulation of lipids and oxidative stress in the liver contribute to nonalcoholic fatty liver disease (NAFLD). We hypothesized that Pinus densiflora Sieb. et Zucc. (PSZ) can protect against NAFLD by regulating lipid accumulation and oxidative stress in the liver.
Jan Fietzke et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(10), 2960-2965 (2015-02-26)
No records exist to evaluate long-term pH dynamics in high-latitude oceans, which have the greatest probability of rapid acidification from anthropogenic CO2 emissions. We reconstructed both seasonal variability and anthropogenic change in seawater pH and temperature by using laser ablation
Egan J Lohman et al.
Biotechnology for biofuels, 8, 82-82 (2015-06-24)
Large-scale algal biofuel production has been limited, among other factors, by the availability of inorganic carbon in the culture medium at concentrations higher than achievable with atmospheric CO2. Life cycle analyses have concluded that costs associated with supplying CO2 to
Ryo Hiramatsu et al.
Journal of pharmaceutical sciences, 104(3), 962-970 (2014-12-30)
Carboranyl-containing chlorins have emerged as promising dual sensitizers for use in both photodynamic therapy (PDT) and boron neutron capture therapy (BNCT), by virtue of their known tumor affinity, low cytotoxicity in dark conditions, and their strong absorptions in the red
C A Alvarado-Gilis et al.
Journal of animal science, 93(6), 3101-3109 (2015-06-27)
Three methods for protection of PUFA against biohydrogenation by ruminal microorganisms were evaluated. In method 1 a blend of ground flaxseed, calcium oxide, and molasses was processed through a dry extruder. In method 2, a blend of ground flaxseed, soybean
Ewan Galbraith et al.
Chemical Society reviews, 39(10), 3831-3842 (2010-09-08)
This critical review will explore some of the recent research into the use of boron based anion receptors and focus on those receptors that have been designed to transduce the binding event into a measurable output signal. In particular the
F Yoshida et al.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 88, 86-88 (2014-04-16)
To determine the influence of buthionine sulfoximine (BSO) on boron biodistribution after sulfhydryl borane (BSH) administration for boron neutron capture therapy, the effectiveness of the combination of BSO with sulfhydril- (BSH) and non-sulfhydril (B12H12 and BNH3) boron compounds, and the
Wenwen Xu et al.
Soft matter, 11(36), 7151-7158 (2015-08-11)
Anisotropic particles have generated an enormous amount of research interest due to their applications for drug delivery, electronic displays and as micromotors. However, up till now, there is no single protocol capable of generating particles of "patchy" composition with a
Linda K Månsson et al.
Faraday discussions, 181, 49-69 (2015-05-15)
We describe a route towards self-assembled colloidal molecules, where thermoresponsive microgels serve as discrete, externally tunable interaction sites. The ability of poly(N-isopropylacrylamide) (PNIPAM) and poly(N-isopropylmethacrylamide) (PNIPMAM) microgels to adsorb to the oil/water (O/W) interface and create Pickering-stabilized mini-emulsions was first
Tomasz M Goszczyński et al.
Biochimica et biophysica acta, 1850(2), 411-418 (2014-12-03)
Boron clusters represent a vast family of boron-rich compounds with extraordinary properties that provide the opportunity of exploitation in different areas of chemistry and biology. In addition, boron clusters are clinically used in boron neutron capture therapy (BNCT) of tumors.
Curtiss D Hunt
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 26(2-3), 157-160 (2012-06-05)
This review summarizes the progress made in establishing essential roles for boron in human physiology and assesses that progress in view of criteria for essentiality of elements. The evidence to date suggests that humans and at least some higher animals
Juan J Camacho-Cristóbal et al.
Plant science : an international journal of experimental plant biology, 181(2), 85-89 (2011-06-21)
Boron (B) is an essential element for plant growth whose deficiency causes an alteration in the expression of a wide range of genes involved in several physiological processes. However, our understanding of the signal transduction pathways that trigger the B-deficiency
Y Wen et al.
Virus genes, 51(1), 1-11 (2015-04-22)
The Hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp), nonstructural protein 5B (NS5B), is anchored in the membrane through a C-terminal helix. A sequence of ca. 12 residues that connects the catalytically competent portion of the RdRp and the C-terminal
Hiroyuki Nakamura
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 133(12), 1297-1306 (2013-12-03)
High accumulation and selective delivery of boron into tumor tissue are the most important requirements to achieve the efficient cell-killing effect of boron neutron capture therapy (BNCT) that relies on the nuclear reaction of two essentially nontoxic species, boron-10 ((10)B)
Henrik Tækker Madsen et al.
Chemosphere, 109, 84-91 (2014-05-31)
Electrochemical oxidation is a promising technique for degradation of otherwise recalcitrant organic micropollutants in waters. In this study, the applicability of electrochemical oxidation was investigated concerning the degradation of the groundwater pollutant 2,6-dichlorobenzamide (BAM) through the electrochemical oxygen transfer process
Alexandre Pfister et al.
eLife, 3, e03115-e03115 (2014-09-19)
The endodermis represents the main barrier to extracellular diffusion in plant roots, and it is central to current models of plant nutrient uptake. Despite this, little is known about the genes setting up this endodermal barrier. In this study, we
Verena Schoepf et al.
PloS one, 9(11), e112011-e112011 (2014-11-15)
Coral skeletal boron isotopes have been established as a proxy for seawater pH, yet it remains unclear if and how this proxy is affected by seawater temperature. Specifically, it has never been directly tested whether coral bleaching caused by high
Andrea J Luthi et al.
Journal of lipid research, 56(5), 972-985 (2015-02-06)
The ability of HDL to support macrophage cholesterol efflux is an integral part of its atheroprotective action. Augmenting this ability, especially when HDL cholesterol efflux capacity from macrophages is poor, represents a promising therapeutic strategy. One approach to enhancing macrophage
Kyoko Miwa et al.
Annals of botany, 105(7), 1103-1108 (2010-03-17)
The essentiality of boron (B) for plant growth was established > 85 years ago. In the last decade, it has been revealed that one of the physiological roles of B is cross-linking the pectic polysaccharide rhamnogalacturonan II in primary cell
Yu-Chieh Tu et al.
Journal of colloid and interface science, 448, 315-319 (2015-03-10)
Here we demonstrated an approach to increase performance of P3HT:TiO2 solar cell either by electron deficient boron or electron rich bismuth doping into TiO2 nanorods. The B doping increases the absorption, crystallinity and electron mobility of TiO2 nanorods. The Bi-doped
Michael Kruse et al.
Molecular nutrition & food research, 59(3), 507-519 (2014-11-19)
Obesity is associated with hyperlipidemia, hepatic steatosis, and low-grade inflammation. Studies have shown that MUFA as well as PUFA have beneficial effects on blood lipids and the inflammatory state. This study investigates the effects of a daily supplementation of either
Laura Ciani et al.
Expert opinion on drug discovery, 7(11), 1017-1027 (2012-09-06)
Boron lies on the borderline between metals and non-metals in the periodic table. As such, it possesses peculiarities which render it suitable for a variety of applications in chemistry, technology and medicine. However, boron's peculiarities have been exploited only partially
Forrest H Nielsen
Gastroenterology, 137(5 Suppl), S55-S60 (2009-11-13)
Boron may be beneficial for bone growth and maintenance, central nervous system function, and the inflammatory response, and silicon may be beneficial for bone maintenance and wound healing. Fluoride is not an essential element but amounts provided by contamination may
Romulus Scorei
Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life, 42(1), 3-17 (2012-04-25)
Boron is probably a prebiotic element with special importance in the so-called "sugars world". Boron is not present on Earth in its elemental form. It is found only in compounds, e.g., borax, boric acid, kernite, ulexite, colemanite and other borates.
Xiaoxia Yang et al.
Small (Weinheim an der Bergstrasse, Germany), 11(30), 3710-3716 (2015-04-29)
A high-quality field emission electron source made of a highly ordered array of carbon nanotubes (CNTs) coated with a thin film of hexagonal boron nitride (h-BN) is fabricated using a simple and scalable method. This method offers the benefit of
Valérie Conway et al.
Prostaglandins, leukotrienes, and essential fatty acids, 91(6), 261-267 (2014-10-11)
Evidences suggest that omega-3 fatty acid (n-3 PUFA) metabolism is imbalanced in apolipoprotein E epsilon 4 isoform carriers (APOE4). This study aimed to investigate APOE genotype-dependant modulation of FA profiles, protein and enzyme important to fatty acid (FA) metabolism in
Amber J Marty et al.
PLoS pathogens, 11(6), e1004959-e1004959 (2015-06-27)
In response to temperature, Blastomyces dermatitidis converts between yeast and mold forms. Knowledge of the mechanism(s) underlying this response to temperature remains limited. In B. dermatitidis, we identified a GATA transcription factor, SREB, important for the transition to mold. Null
Ting Sun et al.
Melanoma research, 24(4), 315-321 (2014-06-11)
Pathobiologic characteristics of cerebral and cutaneous melanoma may cause an increase in mortality resulting from brain metastases in advanced melanoma patients, in addition to anatomic lesions and biological effects caused by the tumor location. We established intracranial and subcutaneous melanoma
Geochemistry: When carbon escaped from the sea.
Katherine A Allen
Nature, 518(7538), 176-177 (2015-02-13)
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