Showing 1-30 of 149 results for "H-089"
Myfanwy Geyer et al.
Pediatrics, 134(6), e1720-e1726 (2014-11-19)
Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy syndrome is a monogenic disorder associated with autoimmune destruction of both endocrine and nonendocrine tissues. The classic triad includes candidiasis, hypoparathyroidism, and Addison disease. Up to 25% of patients with autoimmune polyendocrinopathy candidiasis ectodermal dystrophy...
Lisa Asano et al.
FEBS letters, 587(7), 957-963 (2013-03-07)
Non-secosteroidal ligands for vitamin D receptor (VDR) have been developed for the agonist with non-calcemic profiles. Here, we provide the structural mechanism of VDR agonism by novel non-secosteroidal ligands. All ligands had the similar efficacy, while two had the higher...
Raul A Chavez Valencia et al.
The Journal of steroid biochemistry and molecular biology, 141, 144-149 (2014-02-15)
It is well-established that vitamin D impacts gene regulation via vitamin D response elements (VDREs) across the genome. Recent evidence, primarily at a locus-specific level, suggests that alterations to DNA methylation may also be a relevant mechanism through which vitamin...
Melissa Kallas et al.
The Journal of clinical endocrinology and metabolism, 95(7), 3111-3117 (2010-04-30)
Calcitriol-mediated hypercalcemia resulting from elevated extrarenal 25-hydroxyvitamin D-1alpha-hydroxylase (1alpha-hydroxylase) activity has not previously been described in giant cell polymyositis. We report an unusual case of hypercalcemia due to disseminated granulomatous disease in a 62-yr-old woman with profound proximal muscle weakness...
Ning Ding et al.
Cell, 153(3), 601-613 (2013-04-30)
Liver fibrosis is a reversible wound-healing response involving TGFβ1/SMAD activation of hepatic stellate cells (HSCs). It results from excessive deposition of extracellular matrix components and can lead to impairment of liver function. Here, we show that vitamin D receptor (VDR)...
Bozena Kalvachová
Vnitrni lekarstvi, 58(5), 396-399 (2012-06-22)
New findings regarding the local synthesis of calcitriol, its binding on nuclear receptors and its regional tissue effects have led to discovery of its endocrine microsystems. Their application in growing organisms and their lifelong functionality provide possible preventive and treatment...
K Bratke et al.
Clinical and experimental immunology, 177(1), 366-372 (2014-04-16)
Allergic asthma is a chronic disease of the airways associated with airway hyperresponsiveness, a variable degree of airflow obstruction, airway remodelling and a characteristic airway inflammation. Factors of the vitamin D axis, which include vitamin D metabolites and vitamin D...
Evelyne Van Etten et al.
Journal of cellular biochemistry, 88(2), 223-226 (2003-01-10)
The active form of vitamin D(3), 1,25(OH)(2)D(3), is known, besides its classical effects on calcium and bone, for its pronounced immunomodulatory effects that are exerted both on the antigen-presenting cell level as well as directly on the T lymphocyte level....
Agnes E Nystad et al.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 122(12), 1178-1186 (2014-05-28)
Vitamin D supplementation is increasingly recommended to patients with multiple sclerosis (MS). To study the effect of high-dose vitamin D on remyelination, female C57Bl/6 mice were demyelinated with dietary 0.2% cuprizone for 7 weeks. The mice received intraperitoneal injections of...
R Volchenkov et al.
Scandinavian journal of immunology, 77(4), 246-254 (2013-02-28)
Dendritic cells (DC) are professional antigen-presenting cells that are capable of both activating immune responses and inducing tolerance. Several studies have revealed efficiency of therapeutic vaccination with tolerogenic DC (tolDC) in inhibition of experimental autoimmunity. The purpose of this study...
R S Mason et al.
Annals of internal medicine, 100(1), 59-61 (1984-01-01)
Recent studies suggest that hypercalcemia of sarcoidosis is due to high blood concentrations of calcitriol and that this compound may be synthesized at an extra-renal site. We report that sarcoid lymph node homogenate metabolized calcifediol to a substance indistinguishable from...
Subrata Deb et al.
The Journal of steroid biochemistry and molecular biology, 141, 94-103 (2014-02-04)
The beneficial effects of vitamin D3 are exerted through 1α,25-dihydroxyvitamin D3 [1α,25(OH)2D3], the dihydroxy metabolite of vitamin D3. Hepatic and intestinal biotransformation of 1α,25(OH)2D3 and modifiers of metabolic capacity could be important determinants of bioavailability in serum and tissues. Ginsenosides...
Miki Matsuo et al.
The Journal of steroid biochemistry and molecular biology, 144 Pt A, 201-203 (2013-09-17)
X-ray cocrystallographic studies of the human vitamin D receptor (hVDR)-[2α-(3-hydroxypropyl)-1α,25-dihydroxyvitamin D3 (O1C3)] complex showed that the terminal hydroxy group of the 2α-functional group of O1C3 formed a hydrogen bond with Arg274 in the ligand binding domain (LBD) of hVDR to...
Tanya Seth-Vollenweider et al.
The Journal of biological chemistry, 289(49), 33958-33970 (2014-10-18)
The SWI/SNF chromatin remodeling complex facilitates gene transcription by remodeling chromatin using the energy of ATP hydrolysis. Recent studies have indicated an interplay between the SWI/SNF complex and protein-arginine methyltransferases (PRMTs). Little is known, however, about the role of SWI/SNF...
Andrew G Turner et al.
The Journal of steroid biochemistry and molecular biology, 144 Pt A, 114-118 (2013-10-16)
Maintenance of an adequate vitamin D status, as indicated by the level of circulating 25-hydroxyvitamin D (25(OH)D), is associated with higher bone mass and decreased risk of fracture. However, the molecular actions of vitamin D hormone (1,25(OH)2D3) in bone are...
Mehmet A Ozdemir et al.
Journal of pediatric hematology/oncology, 35(8), 623-627 (2013-10-19)
Thalassemic osteopathy (TOSP) has emerged as a topic of interest, as the optimized transfusion regimens and iron chelations has markedly improved the survival of the patients suffering from thalassemia major (TM) and increased the life expectancy. The aim of this...
Michael B Zemel et al.
Nutrition reviews, 66(10 Suppl 2), S139-S146 (2008-12-05)
Calcitriol, a calcitrophic hormone that can be suppressed by high dietary calcium, favors fatty acid synthesis and inhibits lipolysis via non-genomic modulation of Ca(2+) influx. Calcitriol also suppresses UCP2 expression via the nVDR and thereby increases energy efficiency. Calcitriol exerts...
Justin R Sigmon et al.
The Journal of dermatological treatment, 20(4), 208-212 (2009-05-16)
Topical vitamin D analogs are a safe and effective treatment for psoriasis vulgaris. This is a brief review of calcitriol 3 microg/g ointment in the treatment of psoriasis. Calcitriol has been safely used outside the USA in Europe under the...
David Feldman et al.
Nature reviews. Cancer, 14(5), 342-357 (2014-04-08)
Vitamin D is not really a vitamin but the precursor to the potent steroid hormone calcitriol, which has widespread actions throughout the body. Calcitriol regulates numerous cellular pathways that could have a role in determining cancer risk and prognosis. Although...
Nina Karthaus et al.
The Journal of investigative dermatology, 134(5), 1255-1264 (2013-12-20)
Topical application of the vitamin D (VitD) analog calcipotriol is a highly effective standard treatment modality of psoriatic skin lesions. However, the immune modulatory effects of the treatment are incompletely understood. VitD is well known to induce tolerogenic responses in...
Douglas K Atchison et al.
American journal of physiology. Renal physiology, 305(8), F1109-F1117 (2013-08-09)
1, 25-Dihydroxycholechalciferol (calcitriol) and 19-nor-1, 25-dihydroxyvitamin D2 (paricalcitol) are vitamin D receptor (VDR) agonists. Previous data suggest VDR agonists may actually increase renin-angiotensin activity, and this has always been assumed to be mediated by hypercalcemia. We hypothesized that calcitriol and...
Isabella Sanseverino et al.
The Journal of steroid biochemistry and molecular biology, 144 Pt A, 102-105 (2013-11-05)
CCL2 plays a pivotal role in the recruitment of different immune cells to sites of inflammation and evidence indicates its involvement in multiple sclerosis (MS) pathogenesis. MS lesions are characterized by an inflammatory infiltrate, whose nature is controlled by chemokines...
Matthew D Griffin et al.
The Journal of steroid biochemistry and molecular biology, 97(1-2), 213-218 (2005-07-20)
Therapeutic trials of 1alpha,25(OH)(2)D(3) and related synthetic analogs are merited in diverse clinical fields, including treatment or prevention of bone disease, cancer, immune-mediated diseases, cardiovascular diseases, and prostatic hypertrophy. Potential difficulties of carrying out such trials successfully, include experimental data...
Laura L Sweeney et al.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, 16(3), 459-462 (2010-01-12)
To describe the changes in calcium and calcitriol requirements during pregnancy and lactation in a patient with hypoparathyroidism due to autosomal dominant hypocalcemia. We summarize the clinical presentation and treatment of the patient and review the pertinent literature. Calcitriol requirements...
Linda F Stein Gold
Journal of drugs in dermatology : JDD, 8(8 Suppl), s23-s27 (2009-08-26)
The topical vitamin D3 modulator calcitriol, the naturally occurring active form of vitamin D3, has long been used for topical psoriasis therapy in Europe and other countries and was recently approved in the United States (U.S.) for the treatment of...
Janice García-Quiroz et al.
The Journal of steroid biochemistry and molecular biology, 144 Pt A, 215-222 (2013-10-15)
Calcitriol, a potent antineoplastic vitamin D metabolite, inhibits proliferation, induces apoptosis and slows the growth of tumors. Calcitriol also may exert either antiangiogenic or proangiogenic effects depending on the tissue. Vascular endothelial growth factor (VEGF) and thrombospondin-1 (Tsp-1) are key...
José Manuel González-Sancho et al.
Anticancer research, 26(4A), 2669-2681 (2006-08-05)
Colorectal cancer is a major health problem worldwide. Epidemiological studies and work on experimental animals strongly suggest a protective effect of 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) against colon neoplasia. 1,25(OH)2D3 is a pleiotropic hormone that has multiple actions in the organism. By...
Simple onycholysis: a diagnosis of exclusion.
Nicole F Vélez et al.
Journal of the American Academy of Dermatology, 70(4), 793-794 (2014-03-19)
Nicola Napoli et al.
PloS one, 8(2), e56488-e56488 (2013-02-26)
Vitamin D supplementation in childhood improves the achievement of peak bone mass. We investigated the effect of supplementation with calcitriol on bone turnover in recent-onset type 1 diabetes (T1D). Moreover, the association between osteocalcin and parameters of β-cell function and...
Diego M Carballa et al.
The Journal of steroid biochemistry and molecular biology, 136, 34-38 (2012-10-27)
Convergent syntheses of three new analogues of 1α,25-dihydroxyvitamin D3 with α-hydroxyalkyl substituents at C12 (4a-c) are described. The A-ring and triene system of each analogue were assembled by a tandem Pd-catalysed intramolecular cyclization and Suzuki-Miyaura coupling process. The stereoselective introduction...

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