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Xiaojin Zhang et al.
International journal of oncology, 46(3), 1141-1148 (2014-12-30)
Breast cancer is the most common malignancy in women. The Notch signaling pathway has been shown to be associated with the development and progression of many human cancers, including breast cancer, but the precise mechanism remains unknown. Here, the influence
Claire Regazzetti et al.
The Journal of investigative dermatology, 135(12), 3096-3104 (2015-08-27)
Findings of increased vascularization in melasma lesions and hyperpigmentation in acquired bilateral telangiectatic macules suggested a link between pigmentation and vascularization. Using high-magnification digital epiluminescence dermatoscopy, laser confocal microscopy, and histological examination, we showed that benign vascular lesions of the
Ian A Simpson et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 35(1), 48-57 (2014-10-16)
Neurologic disorders such as Alzheimer's, Parkinson's disease, and Restless Legs Syndrome involve a loss of brain iron homeostasis. Moreover, iron deficiency is the most prevalent nutritional concern worldwide with many associated cognitive and neural ramifications. Therefore, understanding the mechanisms by
Qiang-Hong Pu et al.
Xenobiotica; the fate of foreign compounds in biological systems, 45(3), 213-217 (2014-10-18)
1.Gallic acid is a main polyphenol in various fruits and plants. Inhibitory characteristics of gallic acid on CYP3A4 were still unclear. The objective of this work is hence to investigate inhibitory characteristics of gallic acid on CYP3A4 using testosterone as
Gülmisal Güder et al.
Journal of cardiac failure, 21(3), 208-216 (2015-01-13)
Serum aldosterone and cortisol independently predict an increased mortality risk in heart failure (HF), and mineralocorticoid receptor antagonism (MRA) improves survival. The prognostic relevance of aldosterone and cortisol with MRA is unclear. In this post hoc analysis of a prospective
Ye Zhao et al.
BMC cell biology, 15, 40-40 (2014-12-01)
Endothelial-mesenchymal transition (EndoMT) has been shown to be a major source of myofibroblasts, contributing to kidney fibrosis. However, in vitro study of endothelial cells often relies on culture of isolated primary endothelial cells due to the unavailability of endothelial cell
Muhammad Saddiq Zahari et al.
Journal of proteome research, 14(9), 3882-3891 (2015-08-13)
The human oncogene PIK3CA is frequently mutated in human cancers. Two hotspot mutations in PIK3CA, E545K and H1047R, have been shown to regulate widespread signaling events downstream of AKT, leading to increased cell proliferation, growth, survival, and motility. We used
Antonio Abengózar-Vela et al.
Investigative ophthalmology & visual science, 56(4), 2709-2719 (2015-06-13)
To determine the anti-inflammatory and antioxidant effects of quercetin (QCT) and/or resveratrol (RES) on human conjunctival (IOBA-NHC) and corneal (HCE) epithelial cell lines. IOBA-NHC and HCE cells were treated with QCT (0.5-25 μM), RES (0.5-50 μM) and a low-dose mixture
B Abi Salloum et al.
Endocrinology, 156(6), 2323-2337 (2015-03-13)
Gestational exposure to excess T leads to intrauterine growth restriction, low birth weight, and adult metabolic/reproductive disorders in female sheep. We hypothesized that as early mediators of such disruptions, gestational T disrupts steroidal and metabolic homeostasis in both the mother
Darrell C Bessette et al.
PloS one, 10(5), e0125232-e0125232 (2015-05-15)
Basal-like and triple negative breast cancer (TNBC) share common molecular features, poor prognosis and a propensity for metastasis to the brain. Amplification of epidermal growth factor receptor (EGFR) occurs in ~50% of basal-like breast cancer, and mutations in the epidermal
Weiwei Qi et al.
Diabetes, 64(4), 1407-1419 (2014-11-05)
Diabetic foot ulcer (DFU) caused by impaired wound healing is a common vascular complication of diabetes. The current study revealed that plasma levels of pigment epithelium-derived factor (PEDF) were elevated in type 2 diabetic patients with DFU and in db/db
F Ishikawa et al.
Cell death & disease, 6, e1619-e1619 (2015-01-23)
Anchorage dependence of cellular growth and survival prevents inappropriate cell growth or survival in ectopic environments, and serves as a potential barrier to metastasis of cancer cells. Therefore, obtaining a better understanding of anchorage-dependent responses in normal cells is the
K Wesley Overton et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(41), E4386-E4393 (2014-10-01)
Phenotypic heterogeneity within a population of genetically identical cells is emerging as a common theme in multiple biological systems, including human cell biology and cancer. Using live-cell imaging, flow cytometry, and kinetic modeling, we showed that two states--quiescence and cell
Gerald Bachler et al.
Particle and fibre toxicology, 12, 18-18 (2015-06-28)
The lung epithelial tissue barrier represents the main portal for entry of inhaled nanoparticles (NPs) into the systemic circulation. Thus great efforts are currently being made to determine adverse health effects associated with inhalation of NPs. However, to date very
Qing Sun et al.
Scientific reports, 5, 11560-11560 (2015-06-24)
The current treatments for severe skin injury all involve skin grafting. However, there is a worldwide shortage of donor skin tissue. In this study, we examined the advantages of using human amniotic fluid stem (hAFS) cells in skin wound healing.
Shiri Shahmoon et al.
American journal of physiology. Endocrinology and metabolism, 307(3), E326-E334 (2014-06-19)
Klotho is a transmembranal protein highly expressed in the kidneys, choroid plexus, and anterior pituitary. Klotho can also be cleaved and shed and acts as a circulating hormone. Klotho-deficient mice (kl/kl mice) develop a phenotype resembling early aging. Several lines
Harriët Schellekens et al.
ACS chemical neuroscience, 6(7), 1186-1197 (2015-03-03)
Understanding the intricate pathways that modulate appetite and subsequent food intake is of particular importance considering the rise in the incidence of obesity across the globe. The serotonergic system, specifically the 5-HT2C receptor, has been shown to be of critical
Sin-Hye Park et al.
PloS one, 10(11), e0143526-e0143526 (2015-11-26)
Mucus hypersecretion is an important pathological feature of chronic airway diseases, such as asthma and pulmonary diseases. MUC5AC is a major component of the mucus matrix forming family of mucins in the airways. The initiation of endoplasmic reticulum (ER)-mediated stress
Christian Trummer et al.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 31(10), 819-823 (2015-07-21)
The objective of this study was to analyse the impact of elevated thyroid-stimulating hormone (TSH) levels on the metabolic and endocrine phenotype in 583 women with polycystic ovary syndrome (PCOS). Endocrine and metabolic parameters were measured in all patients and
Zhu-Xu Zhang et al.
Transplantation, 98(10), 1029-1039 (2014-10-07)
Approximately 50% of cardiac transplants fail in the long term, and currently, there are no specific treatments to prevent chronic rejection. In the clinic, donor cardiac graft ischemia time is limited to within a few hours and correlates with delayed
Christopher M Gaviglio et al.
Journal of strength and conditioning research, 28(12), 3447-3452 (2014-06-18)
The aim of this study was to assess the response of salivary-free testosterone and cortisol concentrations across selected midweek skill-based training sessions and their association with subsequent match outcome 3 days later. Twenty-two rugby union players were assessed for salivary-free
Ingrid Stroo et al.
PloS one, 10(4), e0123203-e0123203 (2015-04-16)
Temporal expression of chemokines is a crucial factor in the regulation of renal ischemia/reperfusion (I/R) injury and repair. Beside their role in the migration and activation of inflammatory cells to sites of injury, chemokines are also involved in other processes
E S Mitchell et al.
Climacteric : the journal of the International Menopause Society, 18(4), 536-544 (2015-03-10)
Understanding factors promoting symptom severity is essential to developing innovative symptom management models. To investigate hot flush severity during the menopausal transition (MT) and early postmenopause and effects of age, MT stages, age of onset of late stage and final
Katie A McLaughlin et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(18), 5637-5642 (2015-04-23)
Disruptions in stress response system functioning are thought to be a central mechanism by which exposure to adverse early-life environments influences human development. Although early-life adversity results in hyperreactivity of the sympathetic nervous system (SNS) and hypothalamic-pituitary-adrenal (HPA) axis in
Sung Min Son et al.
Nature communications, 11(1), 3148-3148 (2020-06-21)
Macroautophagy ("autophagy") is the main lysosomal catabolic process that becomes activated under nutrient-depleted conditions, like amino acid (AA) starvation. The mechanistic target of rapamycin complex 1 (mTORC1) is a well-conserved negative regulator of autophagy. While leucine (Leu) is a critical
Kazuki Miyaji et al.
Journal of applied animal welfare science : JAAWS, 18(4), 355-362 (2015-02-14)
The objective of this study was to evaluate the effects of diet on the feline stress response by measuring plasma and urinary cortisol. A study diet was developed with a unique combination of nutrients that supports the management of stressful
Wei-Li Fu et al.
Tissue engineering. Part A, 21(5-6), 948-959 (2014-10-10)
Vascularization of engineered bone tissue is critical for ensuring its survival after implantation and it is the primary factor limiting its clinical use. A promising approach is to prevascularize bone grafts in vitro using endothelial progenitor cells (EPC) derived from
Marianne K Vormann et al.
Journal of pharmaceutical sciences, 110(4), 1601-1614 (2021-02-06)
Proximal tubule epithelial cells (PTEC) are susceptible to drug-induced kidney injury (DIKI). Cell-based, two-dimensional (2D) in vitro PTEC models are often poor predictors of DIKI, probably due to the lack of physiological architecture and flow. Here, we assessed a high throughput
Shinichi Miyagawa et al.
Endocrinology, 156(8), 2795-2806 (2015-05-15)
Androgens are essential for the development, reproduction, and health throughout the life span of vertebrates, particularly during the initiation and maintenance of male sexual characteristics. Androgen signaling is mediated by the androgen receptor (AR), a member of the steroid nuclear
Genevieve F Dunton et al.
Contemporary clinical trials, 43, 142-154 (2015-05-20)
Parental stress is an understudied factor that may compromise parenting practices related to children's dietary intake, physical activity, and obesity. However, studies examining these associations have been subject to methodological limitations, including cross-sectional designs, retrospective measures, a lack of stress
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