Muhammad Saddiq Zahari et al.
Journal of proteome research, 14(9), 3882-3891 (2015-08-13)
The human oncogene PIK3CA is frequently mutated in human cancers. Two hotspot mutations in PIK3CA, E545K and H1047R, have been shown to regulate widespread signaling events downstream of AKT, leading to increased cell proliferation, growth, survival, and motility. We used