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César Fernández-de-Las-Peñas et al.
Pain medicine (Malden, Mass.), 15(8), 1373-1378 (2014-06-27)
The aim of this study is to investigate the differences in salivary cortisol (hypothalamic-pituitary-adrenocortical [HPA] axis), α-amylase activity (sympathetic nervous system [SNS]), and immunoglobulin A (IgA; immune system) concentrations between women with carpal tunnel syndrome (CTS) and healthy women. A...
Athanasios D Anastasilakis et al.
The Journal of clinical endocrinology and metabolism, 99(9), 3247-3255 (2014-06-11)
The myokine irisin may increase energy expenditure and affect metabolism. The objective of the study was to elucidate predictors of irisin and study whether circulating irisin may have day-night rhythm in humans. This was an observational, cross-sectional study with an...
Bizunesh M Borena et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 34(4), 1291-1303 (2014-10-04)
Mammal skin plays a pivotal role in several life preserving processes and extensive damage may therefore be life threatening. Physiological skin regeneration is achieved through ongoing somatic stem cell differentiation within the epidermis and the hair follicle. However, in severe...
Rebecca A Campo et al.
Journal of cancer survivorship : research and practice, 9(1), 115-125 (2014-08-29)
Older cancer survivors are a vulnerable population due to an increased risk for chronic diseases (e.g., cardiovascular disease) compounded with treatment late-effects and declines in physical functioning. Therefore, interventions that reduce chronic disease risk factors (i.e., blood pressure, chronic inflammation...
Zalman Vaksman et al.
PloS one, 9(11), e110263-e110263 (2014-11-18)
Microsatellites (MST), tandem repeats of 1-6 nucleotide motifs, are mutational hot-spots with a bias for insertions and deletions (INDELs) rather than single nucleotide polymorphisms (SNPs). The majority of MST instability studies are limited to a small number of loci, the...
Dina Tell et al.
Psychosomatic medicine, 76(7), 519-528 (2014-09-05)
To examine whether day-to-day variations in sleep behaviors, ongoing sleep disturbance, and fatigue predict the cortisol diurnal rhythm in women recently diagnosed as having early-stage breast cancer. Women (N = 130, mean [standard deviation] age = 55.6 [9.4] years) collected...
Kate R Kuhlman et al.
Psychoneuroendocrinology, 54, 103-114 (2015-02-24)
Studies examining the association between childhood trauma exposure and neuroendocrine functioning have returned inconsistent findings. To date, few studies have accounted for the role exposure to different types of childhood trauma may have on different neuroendocrine adaptations, and no study...
Laurence Guignat et al.
Presse medicale (Paris, France : 1983), 43(4 Pt 1), 366-375 (2014-03-25)
Cushing's syndrome includes all the clinical manifestations induced by chronic glucocorticoid excess. The endogenous Cushing's syndrome is rare, but its prevalence, although difficult to define, is much higher in populations at risk. Data suggest that early and effective management would...
Gustav Schelling et al.
Annals of the New York Academy of Sciences, 1071, 46-53 (2006-08-08)
Like other humans exposed to extreme trauma, patients who have been treated in an intensive care unit (ICU) often report traumatic memories. Extremely traumatic memories from the ICU in some of these patients are associated with the development of posttraumatic...
Rachel Yehuda et al.
Psychoneuroendocrinology, 51, 589-597 (2014-09-13)
Prolonged exposure (PE) therapy for post-traumatic stress disorder (PTSD) in military veterans has established efficacy, but is ineffective for a substantial number of patients. PE is also associated with high dropout rates. We hypothesized that hydrocortisone augmentation would enhance symptom...
Robert Holaj et al.
Journal of hypertension, 33(4), 874-882 (2014-12-10)
Aldosterone has been shown to substantially contribute to the accumulation of different types of collagen fibres and growth factors in the arterial wall, thus increasing wall thickness. A previous study showed reduction of increased common carotid intima-media thickness (IMT) in...
Xiao-Sheng Tian et al.
CNS neuroscience & therapeutics, 21(5), 398-409 (2015-01-23)
This study explored whether surgical stress-induced glucocorticoid receptor (GR) phosphorylation is related to postoperative cognitive dysfunction (POCD) in aged individuals. Inhibition of GR activation could be an effective treatment for POCD. A laparotomy was given to C57/BL6 mice in POCD...
Carol Best et al.
Aquatic toxicology (Amsterdam, Netherlands), 155, 190-198 (2014-07-19)
The antidepressant venlafaxine is detected at parts per billion levels in tertiary-treated municipal wastewater effluent. However, the impact of this serotonin-norepinephrine reuptake inhibitor (SNRI) on non-target aquatic animals is poorly understood. We tested the hypothesis that environmentally relevant levels of...
F Ishikawa et al.
Cell death & disease, 6, e1619-e1619 (2015-01-23)
Anchorage dependence of cellular growth and survival prevents inappropriate cell growth or survival in ectopic environments, and serves as a potential barrier to metastasis of cancer cells. Therefore, obtaining a better understanding of anchorage-dependent responses in normal cells is the...
Weiwei Qi et al.
Diabetes, 64(4), 1407-1419 (2014-11-05)
Diabetic foot ulcer (DFU) caused by impaired wound healing is a common vascular complication of diabetes. The current study revealed that plasma levels of pigment epithelium-derived factor (PEDF) were elevated in type 2 diabetic patients with DFU and in db/db...
Dong Ye et al.
The Analyst, 140(1), 83-97 (2014-10-11)
We report here a protocol to characterise and monitor the quality of in vitro human cellular barrier models using Transmission Electron Microscopy (TEM), which can be applied for transport assays, mechanistic studies and screening of drug/compound (including nanoparticle) penetration across...
Zhu-Xu Zhang et al.
Transplantation, 98(10), 1029-1039 (2014-10-07)
Approximately 50% of cardiac transplants fail in the long term, and currently, there are no specific treatments to prevent chronic rejection. In the clinic, donor cardiac graft ischemia time is limited to within a few hours and correlates with delayed...
Christopher M Gaviglio et al.
Journal of strength and conditioning research, 28(12), 3447-3452 (2014-06-18)
The aim of this study was to assess the response of salivary-free testosterone and cortisol concentrations across selected midweek skill-based training sessions and their association with subsequent match outcome 3 days later. Twenty-two rugby union players were assessed for salivary-free...
Wen Shi et al.
Biomaterials, 35(22), 5760-5770 (2014-04-24)
N-(2-hydroxypropyl)-methacrylamide (HPMA) copolymers have shown promise for application in the detection and staging of cancer. However, non-target accumulation, particularly in the liver and spleen, hinders the detection of resident or nearby metastatic lesions thereby decreasing diagnostic effectiveness. Our laboratory has...
Xiaojin Zhang et al.
International journal of oncology, 46(3), 1141-1148 (2014-12-30)
Breast cancer is the most common malignancy in women. The Notch signaling pathway has been shown to be associated with the development and progression of many human cancers, including breast cancer, but the precise mechanism remains unknown. Here, the influence...
Jorge Oliver-De La Cruz et al.
PloS one, 9(6), e99253-e99253 (2014-06-06)
A number of neurodegenerative diseases progress with a loss of myelin, which makes them candidate diseases for the development of cell-replacement therapies based on mobilisation or isolation of the endogenous neural/glial progenitor cells, in vitro expansion, and further implantation. Cells...
Manuel Gesto et al.
General and comparative endocrinology, 205, 207-217 (2014-04-17)
Based on previous studies we hypothesize that under stress conditions catecholamine-induced hyperglycemia contributes to enhance cortisol production in head kidney of rainbow trout. Therefore, treatment with propranolol (β-adrenoceptor blocker) should reduce the hyperglycemia elicited by stress and, therefore, we expected...
Andrea Oßwald et al.
European journal of endocrinology, 171(2), 209-215 (2014-07-01)
Bilateral adrenalectomy (BADX) is an important treatment option for patients with Cushing's syndrome (CS). Our aim is to analyze the long-term outcomes, surgical, biochemical, and clinical as well as morbidity and mortality, of patients who underwent BADX. A total of...
E Turrini et al.
Journal of ethnopharmacology, 162, 261-269 (2015-01-07)
The decoction of the roots of Hemidesmus indicus is widely used in the Indian traditional medicine for many purposes and poly-herbal preparations containing Hemidesmus are often used by traditional medical practitioners for the treatment of cancer. In the context of...
Reversal of non-suppression of cortisol levels in a patient with refractory depression receiving ketamine.
Robert Ostroff et al.
The American journal of psychiatry, 172(1), 95-96 (2015-01-02)
Felice Strollo et al.
Aviation, space, and environmental medicine, 85(8), 793-797 (2014-09-10)
The Mars-105 project was aimed at simulating crew's activities, workload, and communication during a mission to Mars, evaluating the homeostatic adaptations to prolonged confinement and cohabitation. Fasting plasma glucose (FPG) and insulin, C-peptide, leptin, cortisol, and NGF and BDNF plasma...
Desseree Lysne et al.
Oncology reports, 32(6), 2541-2548 (2014-10-18)
Oral and oropharyngeal cancer together constitute the sixth most common cancer worldwide, with over 400,000 new cases diagnosed each year. Early detection is paramount, as the 5-year survival rate for these cancers decreases markedly once tumors have become regionally invasive....
A G Nilsson et al.
European journal of endocrinology, 171(3), 369-377 (2014-06-20)
The objective was to assess the long-term safety profile of dual-release hydrocortisone (DR-HC) in patients with adrenal insufficiency (AI). Randomised, open-label, crossover trial of DR-HC or thrice-daily hydrocortisone for 3 months each (stage 1) followed by two consecutive, prospective, open-label...
Brandi N Snyder-Talkington et al.
Toxicology, 328, 66-74 (2014-12-17)
There is a current interest in reducing the in vivo toxicity testing of nanomaterials in animals by increasing toxicity testing using in vitro cellular assays; however, toxicological results are seldom concordant between in vivo and in vitro models. This study...
M Santarsieri et al.
Brain, behavior, and immunity, 45, 15-27 (2014-09-15)
Bidirectional communication between the immune and neuroendocrine systems is not well understood in the context of traumatic brain injury (TBI). The purpose of this study was to characterize relationships between cerebrospinal fluid (CSF) cortisol and inflammation after TBI, and to...
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