Showing 1-30 of 41 results for "H1428000"
Maja Vilibić et al.
Collegium antropologicum, 37(1), 317-319 (2013-05-24)
Cobalamin deficiency is associated with a wide spectrum of hematologic, neurologic, gastroenterologic and psychiatric disorders or symptoms. We report a case of a 50-year-old man with complex partial seizures with secondary generalization, mood oscillations and psychotic symptoms alternating with confusion...
Irene García et al.
Plant physiology, 162(4), 2015-2027 (2013-06-21)
Cyanide is produced concomitantly with ethylene biosynthesis. Arabidopsis (Arabidopsis thaliana) detoxifies cyanide primarily through the enzyme β-cyanoalanine synthase, mainly by the mitochondrial CYS-C1. CYS-C1 loss of function is not toxic for the plant and leads to an increased level of...
Optimizing the dose of hydroxocobalamin in cobalamin C (cblC) defect.
Carlo Dionisi-Vici et al.
Molecular genetics and metabolism, 109(4), 329-330 (2013-06-15)
Cobalamin supplements for infants: a shot in the cradle?
Ralph Green
The American journal of clinical nutrition, 98(5), 1149-1150 (2013-09-27)
Transfusion Medicine Illustrated: an unusual cause of red plasma.
Eric Gehrie et al.
Transfusion, 54(1), 11-11 (2014-01-11)
S W Sauer et al.
Annals of emergency medicine, 37(6), 635-641 (2001-06-01)
The United States is under the constant threat of a mass casualty cyanide disaster from industrial accidents, hazardous material transportation incidents, and deliberate terrorist attacks. The current readiness for cyanide disaster by the emergency medical system in the United States...
Brian V Cashin et al.
Prehospital and disaster medicine, 28(4), 367-369 (2013-05-03)
The newer cyanide antidote, hydroxocobalamin, due to its pigmentation, has been found to cause interferences in some laboratory assays. Co-oximetry may also be affected by hydroxocobalamin, leading to false elevations in hemoglobin concentration, methemoglobin, carboxyhemoglobin, and false decreases in oxyhemoglobin....
Is hydroxocobalamin safe and effective for smoke inhalation? Searching for guidance in the haze.
Andrew R Erdman
Annals of emergency medicine, 49(6), 814-816 (2007-05-22)
Letter in response to "The Vitamin B12 analog cobinamide is an effective hydrogen sulfide antidote in a lethal rabbit model".
Denise Fernández et al.
Clinical toxicology (Philadelphia, Pa.), 53(1), 73-73 (2014-12-02)
[Advances in the clinical and laboratory studies on methylmalonic aciduria combined with homocysteinemia type cblC].
Yu-Peng Liu et al.
Zhonghua er ke za zhi = Chinese journal of pediatrics, 51(4), 313-316 (2013-08-10)
Intravenous cobinamide versus hydroxocobalamin for acute treatment of severe cyanide poisoning in a swine (Sus scrofa) model.
Kurt Schapira et al.
Annals of emergency medicine, 65(2), 234-235 (2015-01-21)
André L F Sampaio et al.
Mediators of inflammation, 2013, 741804-741804 (2013-06-20)
NOS/•NO inhibitors are potential therapeutics for sepsis, yet they increase clinical mortality. However, there has been no in vivo investigation of the (in vitro) •NO scavenger, cobalamin's (Cbl) endogenous effects on NOS/•NO/inflammatory mediators during the immune response to sepsis. We...
Rumiko Kondo
Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology, 27(1), 59-62 (2014-04-15)
Hydroxocobalamin as a cyanide antidote.
Carol Ann DesLauriers et al.
American journal of therapeutics, 13(2), 161-165 (2006-04-29)
Joseph D Roderique et al.
The Annals of thoracic surgery, 97(5), 1785-1786 (2014-05-06)
We describe a case of hypotension on cardiopulmonary bypass for coronary artery bypass grafting, double valve repairs, and patent foramen ovale closure. The patient experienced vasoplegic syndrome while on cardiopulmonary bypass. He was treated with high-dose hydroxocobalamin (vitamin B12). His...
Ingrid Torsvik et al.
The American journal of clinical nutrition, 98(5), 1233-1240 (2013-09-13)
During infancy, minor developmental delays and gastrointestinal complaints are common, as is a biochemical profile indicative of impaired cobalamin status. We investigated whether cobalamin supplementation can improve development or symptoms in infants with biochemical signs of impaired cobalamin function and...
H Nafil et al.
Bulletin de la Societe de pathologie exotique (1990), 106(2), 83-88 (2013-03-29)
The aim of this study is to examine retrospectively the clinical, biological and treatment features of anemia by vitamin B12 deficiency in the Hematology department of CHU Mohamed VI Marrakech. We report the results of a retrospective study conducted during...
F A Cisse et al.
Bulletin de la Societe de pathologie exotique (1990), 106(3), 156-159 (2013-06-25)
Neurological disorders related to vitamin B12 deficiency are common in prisons of tropical Africa. We collected 22 cases (20 men and 2 women). They all showed vitamin B12 deficiency associated with neurological signs that were represented by sclerosis combined with...
Alan H Hall et al.
Annals of emergency medicine, 49(6), 806-813 (2006-11-14)
Cyanide poisoning must be seriously considered in victims of smoke inhalation from enclosed space fires; it is also a credible terrorism threat agent. The treatment of cyanide poisoning is empiric because laboratory confirmation can take hours or days. Empiric treatment...
Michael D Keller et al.
Pediatrics, 131(2), e629-e634 (2013-01-09)
Folate and vitamin B(12) metabolism are essential for de novo purine synthesis, and several defects in these pathways have been associated with immunodeficiency. Here we describe the occurrence of severe combined immunodeficiency (SCID) with megaloblastic anemia, leukopenia, atypical hemolytic uremic...
Hydroxocobalamin in chronic cyanide poisoning.
C Bismuth et al.
Journal de toxicologie clinique et experimentale, 8(1), 35-38 (1988-01-01)
John P Thompson et al.
Clinical toxicology (Philadelphia, Pa.), 50(10), 875-885 (2012-11-21)
On theoretical grounds, hydroxocobalamin is an attractive antidote for cyanide poisoning as cobalt compounds have the ability to bind and detoxify cyanide. This paper reviews the pharmacokinetic and pharmacodynamic aspects of hydroxocobalamin, its efficacy in human cyanide poisoning and its...
I Vaz Matos et al.
Molecular genetics and metabolism, 109(4), 360-365 (2013-06-12)
CblC deficiency produces a combination of methylmalonic aciduria (MMA) and homocystinuria (HCU), and is the most common error of cobalamin metabolism. Patients present a wide spectrum of symptoms, ranging from early severe multisystemic forms, to milder late-onset phenotypes. Cognitive and...
Vikhyat S Bebarta et al.
Annals of emergency medicine, 64(6), 612-619 (2014-04-22)
Hydroxocobalamin is a Food and Drug Administration-approved antidote for cyanide poisoning. Cobinamide is a potential antidote that contains 2 cyanide-binding sites. To our knowledge, no study has directly compared hydroxocobalamin with cobinamide in a severe, cyanide-toxic large-animal model. Our objective...
G Geldner et al.
Der Anaesthesist, 62(8), 609-616 (2013-08-07)
This is a report on an international non-interventional study of patients exposed to fires with smoke development in closed rooms. The objective of the study was to document clinical symptoms, relevant laboratory values and blood cyanide concentrations from fire victims...
Martin Kömhoff et al.
Pediatrics, 132(2), e540-e544 (2013-07-10)
Pulmonary arterial hypertension (PAH) and renal thrombotic microangiopathy (rTMA) are rare diseases in childhood, frequently leading to death and end-stage renal disease, respectively. Their combined occurrence has been reported anecdotally. We investigated the clinical, biochemical, and genetic aspects of 5...
Greene Shepherd et al.
The Annals of pharmacotherapy, 42(5), 661-669 (2008-04-10)
To review the recently approved cyanide antidote, hydroxocobalamin, and describe its role in therapy. Relevant publications were identified through a systematic search of PubMed using the MeSH terms and key words hydroxocobalamin and cyanide. This search was then limited to...
Hydroxocobalamin hinders hemodialysis.
Samuel J Stellpflug et al.
American journal of kidney diseases : the official journal of the National Kidney Foundation, 62(2), 395-395 (2013-06-19)
Zhuo Huang et al.
Zhonghua er ke za zhi = Chinese journal of pediatrics, 51(3), 194-198 (2013-06-12)
Combined methylmalonic acidemia with homocystinuria is a common form of methylmalonic acidemia in China. Patients with this disease can progress to death without timely and effective treatment. This study aimed to analyze the treatment outcomes of patients with combined methylmalonic...
Jose Avila et al.
Clinical nephrology, 79(4), 323-325 (2013-03-30)
Hydroxocobalamin is a treatment for cyanide toxicity with few side effects. We report a case of a hemodialysis patient whose treatment was compromised by hydroxocobalamin interference with the blood leak detector.

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