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H31204

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Ute F Röhrig et al.
Journal of medicinal chemistry, 53(3), 1172-1189 (2010-01-09)
Indoleamine 2,3-dioxygenase (IDO) is an important therapeutic target for the treatment of diseases such as cancer that involve pathological immune escape. We have used the evolutionary docking algorithm EADock to design new inhibitors of this enzyme. First, we investigated the...
Pooja V Reddy et al.
Archives of microbiology, 200(1), 171-182 (2017-09-25)
A high-efficiency fluoranthene-degrading bacterium Paenibacillus sp. PRNK-6 was isolated from PAH-contaminated soil. The strain degrades 96% (240 mg l
L Bastiaens et al.
Research in microbiology, 152(10), 849-859 (2002-01-05)
The promoter probe mini-Tn5-luxAB-tet was used to create a luxAB transcriptional fusion responding to fluorene in the fluorene utilising bacterium Sphingomonas sp. LB126. The mutant strain, named L-132, was impaired in fluorene utilisation and strongly emitted light upon addition of...
Tian Li et al.
Chemosphere, 218, 992-1001 (2019-01-06)
Exposure to fine particulate matter (PM2.5) is linked to various respiratory outcomes. However, the associations of concentrations of PM2.5-bound polycyclic aromatic hydrocarbons (PM2.5-bound PAHs) with airway inflammatory indices remains unclear. To assess effects of short-term exposure to PM2.5-bound PAHs on...
Microbial reduction of 9-fluorenone to 9-hydroxyfluorene in carbon-filtered water: a confounding factor in an aquatic bioassay of 9-fluorenone with larvae of the midge, Chironomus tentans (Fabr.).
P W O'Keefe et al.
Bulletin of environmental contamination and toxicology, 75(6), 1060-1066 (2006-01-13)
Derek Dunn et al.
Bioorganic & medicinal chemistry letters, 22(11), 3751-3753 (2012-05-02)
In searching for a next generation molecule to the novel wake promoting agent modafinil (compound 1), a series of fluorene-derived wakefulness enhancing agents were developed and evaluated in rat. Extensive pharmacokinetic studies of a potent member of the series (compound...
C Chen et al.
Drug metabolism and disposition: the biological fate of chemicals, 12(4), 421-426 (1984-07-01)
Fluoren-9-ol and fluoren-9-one were used as model substrates to study microsomal metabolism of alcohols and carbonyl compounds. It was found that there was an oxidoreductase(s) present in the microsomal preparation that catalyzed interconversion of this alcohol and ketone using pyridine...
Nesta Bortey-Sam et al.
Environmental pollution (Barking, Essex : 1987), 228, 311-320 (2017-05-30)
Studies of polycyclic aromatic hydrocarbons (PAHs) and its metabolites in PM10, soils, rat livers and cattle urine in Kumasi, Ghana, revealed high concentrations and cancer potency. In addition, WHO and IARC have reported an increase in cancer incidence and respiratory...
Yaqi Hu et al.
The Analyst, 140(13), 4662-4667 (2015-05-20)
Direct and rapid detection of 1-hydroxypyrene (1-OHP) is of great importance owing to its high carcinogenicity, teratogenicity and toxicity. In this study, a simple colorimetric assay for rapid determination of 1-OHP is reported, which is based on non-crosslinking aggregation of...
Biban Gill et al.
Analytical and bioanalytical chemistry, 411(7), 1397-1407 (2019-01-27)
Urinary 1-hydroxypyrene (OH-Pyr) is widely used for biomonitoring human exposures to polycyclic aromatic hydrocarbons (PAHs) from air pollution and tobacco smoke. However, there have been few rigorous validation studies reported to ensure reliable OH-Pyr determination for occupational health and risk...
Chiara Giorio et al.
Chemosphere, 224, 786-795 (2019-03-10)
Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous atmospheric pollutants of high concern for public health. In the atmosphere they undergo oxidation, mainly through reactions with ·OH and NOx to produce nitro- and oxygenated (oxy-) derivatives. In this study, we developed a...
Amarnath Singh et al.
Clinica chimica acta; international journal of clinical chemistry, 452, 204-213 (2015-12-01)
Indoor air pollution is associated with decreased pulmonary function but the relative impact of pollution from kitchen sources on health risks in kitchen workers is not well-known or studied. A study was conducted to measure the kitchen indoor air quality...
Yueh-Ying Han et al.
Pediatric pulmonology, 53(10), 1362-1368 (2018-06-27)
It is unclear whether exposure to polycyclic aromatic hydrocarbons (PAH) affects lung function in children with asthma. Whether vitamin D insufficiency enhances any detrimental effects of PAH on lung function in asthmatic children is also unknown. Cross-sectional study of 1,821...
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