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Abu M M T Reza et al.
Cell biology international, 39(4), 400-410 (2014-12-11)
Mesenchymal-epithelial transition (MET) is an inevitable process for cellular reprogramming. MET could be induced by suppressing epithelial-mesenchymal transition (EMT) signaling and activating an epithelial program within the cells. Aiming at MET, we investigated the potential of keratinocyte growth factor (KGF)...
Tina Kauss et al.
Arthritis research & therapy, 10(1), R19-R19 (2008-02-07)
Dietary flavonols may play an important role in the adjunct therapy of chronic inflammation. The availability of therapeutic formulations of pentahydroxyflavone glycoside, rutoside (RU), led us to investigate the ability of this molecule to modulate the release of various proinflammatory...
Thomas Reinehr et al.
The Journal of clinical endocrinology and metabolism, 98(6), E1022-E1030 (2013-05-25)
Little information is available on the steroid hormone profiles in obese children and their changes after weight loss. We compared liquid chromatography-tandem mass spectrometry of serum steroid hormone profiles between obese and normal-weight children and studied the differential effects of...
Camilla Brorsson et al.
Clinical endocrinology, 81(2), 244-248 (2014-02-14)
In critically ill patients with hypotension, who respond poorly to fluids and vasoactive drugs, cortisol insufficiency may be suspected. In serum over 90% of cortisol is protein-bound, thus routine measures of total serum cortisol may yield 'false lows' due to...
Thibaud Cherbuin et al.
Stem cell reviews, 11(3), 460-473 (2014-10-07)
The epidermis is mainly composed of keratinocytes forming a protective barrier. It is perpetually subjected to mechanical stress and strain during development, homeostasis and disease. Perturbation of the normal strain with alteration of its biological response may lead to severe...
Chao-Ching Chang et al.
Cancer research, 75(11), 2375-2386 (2015-04-05)
Obesity has been linked to breast cancer progression but the underlying mechanisms remain obscure. Here we report how leptin, an obesity-associated adipokine, regulates a transcriptional pathway to silence a genetic program of epithelial homeostasis in breast cancer stem-like cells (CSC)...
Zihuai He et al.
PloS one, 10(5), e0126637-e0126637 (2015-05-21)
The hormone cortisol is likely to be a key mediator of the stress response that influences multiple physiologic systems that are involved in common chronic disease, including the cardiovascular system, the immune system, and metabolism. In this paper, a candidate...
Caroline Jung et al.
BMC endocrine disorders, 14, 91-91 (2014-11-27)
Glucocorticoid replacement is essential in patients with primary and secondary adrenal insufficiency, but many patients remain on higher than recommended dose regimens. There is no uniformly accepted method to monitor the dose in individual patients. We have compared cortisol concentrations...
Medicine. A unified cause for adrenal Cushing's syndrome.
Lawrence S Kirschner
Science (New York, N.Y.), 344(6186), 804-805 (2014-05-24)
Ariadna Perez-Balaguer et al.
Breast cancer research and treatment, 153(2), 465-474 (2015-08-25)
The FOXA family of transcription factors regulates chromatin structure and gene expression especially during embryonic development. In normal breast tissue FOXA1 acts throughout mammary development; whereas in breast carcinoma its expression promotes luminal phenotype and correlates with good prognosis. However...
Serafino Ricci et al.
Rivista di psichiatria, 48(2), 113-120 (2013-06-12)
Man devotes most of the daily time to work, and also a large part of physical and mental resources. Depression and many other morbid conditions can be related etiopathologically to the performance of a dangerous occupation in terms of quality...
Yin-Sha Miao et al.
Cellular signalling, 27(1), 156-167 (2014-12-03)
The purposes of this study were to investigate the possible molecular mechanisms of miR-18a regulating the permeability of blood-tumor barrier (BTB) via down-regulated expression and distribution of runt-related transcription factor 1 (RUNX1). An in vitro BTB model was established with...
Jing-Jie Yu et al.
Journal of clinical psychopharmacology, 35(4), 406-410 (2015-06-13)
Major depressive disorder is a devastating mental illness leading to a lifetime prevalence of higher than 16% on individuals. The treatment delay and inevitable adverse effects are major limitations of current depression interventions. Emerging evidence indicates that curcumin produced significant...
Melanie Schorr et al.
The Journal of clinical endocrinology and metabolism, 100(9), 3313-3321 (2015-07-15)
There are conflicting reports of increased vs decreased hypothalamic-pituitary-adrenal (HPA) activation in obesity; the most consistent finding is an inverse relationship between body mass index (BMI) and morning cortisol. In anorexia nervosa (AN), a low-BMI state, cortisol measures are elevated....
Antonella Sassano et al.
Molecular and cellular biology, 35(15), 2684-2698 (2015-05-28)
We provide evidence that human SLFN5, an interferon (IFN)-inducible member of the Schlafen (SLFN) family of proteins, exhibits key roles in controlling motility and invasiveness of renal cell carcinoma (RCC) cells. Our studies define the mechanism by which this occurs...
Sarah T Boyle et al.
Molecular cancer, 14, 115-115 (2015-06-07)
The expression of the chemokine receptor CCR6 has been previously correlated with higher grades and stages of breast cancer and decreased relapse-free survival. Also, its cognate chemokine ligand CCL20 has been reported to induce proliferation of cultured human breast epithelial...
Adilson Kleber Ferreira et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 36(9), 7251-7267 (2015-04-22)
Capsaicin, the primary pungent component of the chili pepper, has antitumor activity. Herein, we describe the activity of RPF151, an alkyl sulfonamide analogue of capsaicin, against MDA-MB-231 breast cancer cells. RPF151 was synthetized, and molecular modeling was used to compare...
Ciara Leydon et al.
PloS one, 9(12), e115389-e115389 (2014-12-17)
Vocal fold epithelial cells likely play an important, yet currently poorly defined, role in healing following injury, irritation and inflammation. In the present study, we sought to identify a possible role for growth factors, epidermal growth factor (EGF) and transforming...
Gabriela Schneider et al.
Molecular cancer, 14, 201-201 (2015-11-26)
One of the challenging problems of current radio-chemotherapy is recurrence and metastasis of cancer cells that survive initial treatment. We propose that one of the unwanted effects of radiochemotherapy is the release from damaged ("leaky") cells of nucleotides such as...
Liselotte van Bloemendaal et al.
Diabetes, 63(12), 4186-4196 (2014-07-30)
Gut-derived hormones, such as GLP-1, have been proposed to relay information to the brain to regulate appetite. GLP-1 receptor agonists, currently used for the treatment of type 2 diabetes (T2DM), improve glycemic control and stimulate satiety, leading to decreases in...
Meiling Sun et al.
Neurochemistry international, 80, 99-109 (2014-12-03)
We previously found that TIGAR (TP53-induced glycolysis and apoptosis regulator) was upregulated in response to ischemia/reperfusion insult in a TP53-independent manner. The present study sought to investigate the regulatory mechanisms of TIGAR upregulation in animal and cellular models of stroke....
J R Miles et al.
Journal of animal science, 93(4), 1555-1564 (2015-05-29)
Crossbreeding studies between Meishan (MS) and Large White (LW) pigs have illustrated that increased piglet growth before weaning is attributed to the maternal genotype of LW dams. The objective of this study was to determine the contributions of the maternal...
Teraneh Z Jhaveri et al.
Oncotarget, 6(17), 14754-14765 (2015-07-06)
AMP-activated Protein Kinase (AMPK) activity retards growth of many types of cancers. Investigating effects of AMPK activation on breast cancer cell signaling and survival, we found that breast cancer cell lines with amplification and over-expression of HER2 or EGFR are...
Lei Zhao et al.
Journal of immunotherapy (Hagerstown, Md. : 1997), 38(6), 217-228 (2015-06-08)
A critical obstacle in advanced colorectal cancer (CRC) treatment is the insufficient improvement on survival of conventional chemotherapy. Cancer stem cells are reported to be one of the crucial explanations. CD133 has been identified as a surface marker of CRC...
E Lee et al.
Cell death & disease, 6, e1805-e1805 (2015-07-03)
Reciprocal interactions between cancer cells and the tumor microenvironment drive multiple clinically significant behaviors including dormancy, invasion, and metastasis as well as therapy resistance. These microenvironment-dependent phenotypes share typical characteristics with cancer stem cells (CSC). However, it is poorly understood...
S D Mesquita et al.
Cell death and differentiation, 21(10), 1588-1599 (2014-05-24)
The production, accumulation and aggregation of amyloid beta (Aβ) peptides in Alzheimer's disease (AD) are influenced by different modulators. Among these are iron and iron-related proteins, given their ability to modulate the expression of the amyloid precursor protein and to...
D A Vassiliadi et al.
The Journal of clinical endocrinology and metabolism, 100(9), 3478-3485 (2015-07-07)
The bilateral formation of nodules indicates that the pathogenesis of bilateral adrenal incidentalomas (AI) may differ from that of unilateral AI. A possible role of hypothalamo-pituitary-adrenal (HPA) axis dysregulation in their formation has not been investigated. The objective of the...
S Marti et al.
Journal of animal science, 93(4), 1581-1591 (2015-05-29)
Angus crossbred bulls (n = 60; 257 ± 5.4 d of age; initial BW 358.8 ± 3.78 kg) were used to study the effect of a vaccine against gonadotropin-releasing factor (GnRF) and band castration on behavioral and physiological indicators of...
Hyojin Lee et al.
ACS nano, 9(10), 9859-9867 (2015-09-04)
This paper describes how gold nanoparticle nanoconstructs can enhance anticancer effects of lysosomal targeting aptamers in breast cancer cells. Nanoconstructs consisting of anti-HER2 aptamer (human epidermal growth factor receptor 2, HApt) densely grafted on gold nanostars (AuNS) first targeted HER2...
Kira S Birditt et al.
Journal of social and personal relationships, 32(5), 687-706 (2015-07-28)
An important pathway by which relationships influence health may involve how people cope with interpersonal tensions. This study examined whether same day and prior day avoidance and engagement in arguments are differentially associated with self-reported well-being (emotional, physical) and diurnal...
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