Showing 1-30 of 1688 results for "


Thais B Ferreira et al.
Brain, behavior, and immunity, 41, 182-190 (2014-06-03)
Dopamine (DA) is a neurotransmitter produced mainly in the central nervous system (CNS) that has immunomodulatory actions on T cells. As the multiple sclerosis (MS) has long been regarded as an autoimmune disease of CNS mediated by T cells, the...
Irene Manrique et al.
Cancer letters, 356(2 Pt B), 899-909 (2014-12-03)
Id1 has been shown to play a critical role in tumorigenesis and angiogenesis. Moreover, recent reports have involved Id1 in the maintenance of cancer stem cell features in some tumor types. The Id1 gene generates two isoforms through alternative splicing:...
Chengming Fei et al.
European journal of haematology, 93(6), 476-486 (2014-06-04)
The contribution of bone marrow mesenchymal stromal cells (BMMSCs) to the pathogenesis of myelodysplastic syndrome (MDS) has created controversies. In this study, we confirmed that BMMSCs from MDS patients showed prominent features of senescence, which were characterized by increased cell...
Andreas Noack et al.
PloS one, 9(2), e88154-e88154 (2014-02-08)
P-glycoprotein (Pgp; ABCB1/MDR1) is a major efflux transporter at the blood-brain barrier (BBB), restricting the penetration of various compounds. In other tissues, trafficking of Pgp from subcellular stores to the cell surface has been demonstrated and may constitute a rapid...
Angelico Madaro et al.
The Journal of experimental biology, 218(Pt 16), 2538-2550 (2015-06-10)
Combinations of stressors occur regularly throughout an animal's life, especially in agriculture and aquaculture settings. If an animal fails to acclimate to these stressors, stress becomes chronic, and a condition of allostatic overload arises with negative results for animal welfare....
A Shimasue et al.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 123(1), 48-54 (2014-10-15)
Detection and analysis of a small subpopulation of cells such as stem cells or cancer stem cells are recognized to be a key technique in a recent regeneration and cancer science. However, in the thyroid, no marker that identifies stem...
T He et al.
Oncogene, 33(27), 3538-3549 (2013-09-10)
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising agent in selectively killing tumor cells. However, TRAIL monotherapy has not been successful as many cancer cells are resistant to TRAIL. Chemotherapeutic agents, such as doxorubicin have been shown to act...
Ville Koistinen et al.
Experimental cell research, 337(2), 179-191 (2015-07-15)
Previous studies have shown that overexpression of enzymatically active GFP-HAS induces the growth of long, slender protrusions that share many features of both filopodia and microvilli. These protrusions are dependent on continuing hyaluronan synthesis, and disrupt upon digestion of hyaluronan...
Empathy under stress: Gender-specific effects on empathic accuracy.
Nitschke J, Sunahara C, Pruessner J, et al.
Psychoneuroendocrinology, 61, 63-63 (2015)
Preeti Sahu et al.
Soft matter, 16(13), 3325-3337 (2020-03-21)
Surface tension governed by differential adhesion can drive fluid particle mixtures to sort into separate regions, i.e., demix. Does the same phenomenon occur in confluent biological tissues? We begin to answer this question for epithelial monolayers with a combination of...
Hye Jin Moon et al.
American journal of physical medicine & rehabilitation, 93(5), 372-378 (2014-02-11)
The aim of this study was to investigate the changes in blood glucose and cortisol levels after glucocorticoid injections into the epidural space or the glenohumeral joint in patients with or without diabetes. Twenty-nine patients with sciatic or shoulder pain...
Centdrika R Dates et al.
Cancer biology & therapy, 16(5), 714-723 (2015-05-23)
Increased aerobic glycolysis and de novo lipid biosynthesis are common characteristics of invasive cancers. UDP-glucuronosyltransferases (UGTs) are phase II drug metabolizing enzymes that in normal cells possess the ability to glucuronidate these lipids and speed their excretion; however, de-regulation of...
Stéphane Chabaud et al.
Journal of tissue engineering and regenerative medicine, 9(11), E65-E75 (2013-02-19)
The time needed to produce engineered tissue is critical. A self-assembly approach provided excellent results regarding biological functions and cell differentiation because it closely respected the microenvironment of cells. Nevertheless, the technique was time consuming for producing tissue equivalents with...
Silvia U Maier et al.
Neuron, 87(3), 621-631 (2015-08-08)
Important decisions are often made under stressful circumstances that might compromise self-regulatory behavior. Yet the neural mechanisms by which stress influences self-control choices are unclear. We investigated these mechanisms in human participants who faced self-control dilemmas over food reward while...
Gergely Montskó et al.
Fertility and sterility, 103(3), 687-693 (2015-01-13)
To find new candidate molecules to assess embryo viability in a noninvasive manner. Prospective, blinded study with randomized sample collection. University research center. Ninety embryos implanted in 53 randomly selected patients (mean ± SD age, 32.3 ± 5.1 years) were analyzed....
Lars Niklasson et al.
PloS one, 9(5), e94288-e94288 (2014-05-09)
Infectious pancreatic necrosis virus (IPNV) causes high incidence of disease in salmonids during the first period after SW transfer. During this period as well as during periods of stress, cortisol levels increase and indications of a relationship between IPNV susceptibility...
Nadja Zöller et al.
Dermatology (Basel, Switzerland), 229(3), 190-198 (2014-09-18)
The treatment regime of non-healing or slowly healing wounds is constantly improving. One aspect is surgical defect coverage whereby mesh grafts and keratinocyte suspension are applied. Tissue-cultured skin autografts may be an alternative for the treatment of full-thickness wounds and...
S Livadas et al.
Clinical endocrinology, 82(4), 543-549 (2014-07-22)
Nonclassical congenital adrenal hyperplasia (NC-CAH) is caused by mutations of the CYP21A2 gene. The clinical manifestations and hormonal derangements of NC-CAH are quite variable. (i) To define the phenotype and its relation to genotype according to gender and age and...
Andrew C Lidral et al.
Human molecular genetics, 24(14), 3895-3907 (2015-02-06)
Three common diseases, isolated cleft lip and cleft palate (CLP), hypothyroidism and thyroid cancer all map to the FOXE1 locus, but causative variants have yet to be identified. In patients with CLP, the frequency of coding mutations in FOXE1 fails...
I A Odeniyi et al.
Nigerian journal of clinical practice, 16(3), 269-272 (2013-06-19)
Cushing's syndrome results from chronic exposure to excessive circulating levels of glucocorticoids. To confirm the clinical suspicion, biochemical tests are needed. These biochemical tests include the measurement of excess total endogenous cortisol secretion assessed by 24-hour urinary free cortisol (UFC)...
Jaime E Mirowsky et al.
Environmental health : a global access science source, 14, 66-66 (2015-08-16)
Previous human exposure studies of traffic-related air pollutants have demonstrated adverse health effects in human populations by comparing areas of high and low traffic, but few studies have utilized microenvironmental monitoring of pollutants at multiple traffic locations while looking at...
Omar M Benavides et al.
Journal of biomedical materials research. Part A, 103(8), 2645-2653 (2015-01-30)
One of the greatest challenges in regenerative medicine is generating clinically relevant engineered tissues with functional blood vessels. Vascularization is a key hurdle faced in designing tissue constructs larger than the in vivo limit of oxygen diffusion. In this study...
Adrenal steroid receptors and actions in the nervous system.
B S McEwen et al.
Physiological reviews, 66(4), 1121-1188 (1986-10-01)
Kaikai Shen et al.
Molecular cancer therapeutics, 14(7), 1738-1749 (2015-05-16)
Cambogin is a polycyclic polyprenylated acylphoroglucinol (PPAP) from the Garcinia genus, which has been used traditionally for cancer treatment across Southeastern Asia. In this study, we found that cambogin inhibited breast cancer cell proliferation and induced cell apoptosis in vitro....
Corinna Peifer et al.
Psychopharmacology, 232(6), 1165-1173 (2014-10-12)
Stress affects flow-experience, but the mediating psychobiological mechanisms remain unknown. Previous studies showed an association between flow-experience and endogenous cortisol levels, suggesting an inverted, u-shaped relation between flow-experience and cortisol. However, these studies could not exclude effects of other stress...
Alexey E Bigildeev et al.
Cytokine, 71(2), 246-254 (2014-12-03)
Multipotent mesenchymal stromal cells (MMSCs) have been demonstrated to produce mature stromal cells and maintain hematopoietic progenitor cells (HPC). It was previously demonstrated that interleukin-1 beta (IL-1 beta) stimulates the growth of the stromal microenvironment in vivo. The aim of...
Serge Brand et al.
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, 16(2), 96-105 (2014-02-26)
Patients with aneurysmal subarachnoid haemorrhage (aSAH) have impaired sleep and cognitive performance together with more difficulties in social and everyday life. Hypocortisolism has also been reported. However, a study assessing all dimensions between aSAH severity, objective and subjective sleep, cortisol...
Meng Lv et al.
Oncology reports, 33(4), 1938-1946 (2015-02-04)
Angiomotin (Amot) is a multifunctional protein involved in endothelial cell migration and tube formation and angiogenesis. However, the biological role and molecular mechanism for the abnormal expression of Amot in breast cancer is poorly understood. The aim of the present...
Bruno Dumas et al.
Biotechnology journal, 1(3), 299-307 (2006-08-10)
Inspired by the successful work of converting Saccharomyces cerevisiae into an microorganism capable of synthesizing hydrocortisone, a 27-carbon molecule, from ethanol, a 2-carbon molecule, this review provides an overview of the potential of yeast as a recombinant organism in the...