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Showing 1-18 of 18 results for "h4385" within Papers
Barbara Zonta et al.
Neuron, 69(5), 945-956 (2011-03-09)
The axon initial segment (AIS) is critical for the initiation and propagation of action potentials. Assembly of the AIS requires interactions between scaffolding molecules and voltage-gated sodium channels, but the molecular mechanisms that stabilize the AIS are poorly understood. The
Maria Sara Remedi et al.
PLoS medicine, 5(10), e206-e206 (2008-10-31)
Pancreatic beta-cell ATP-sensitive potassium (K ATP) channels are critical links between nutrient metabolism and insulin secretion. In humans, reduced or absent beta-cell K ATP channel activity resulting from loss-of-function K ATP mutations induces insulin hypersecretion. Mice with reduced K ATP
Shusei Mizushima et al.
Methods in molecular biology (Clifton, N.J.), 1650, 243-257 (2017-08-16)
A characteristic biological property of avian gamete (e.g., extremely large egg and polyspermic fertilization) does not allow the direct observation of sperm-egg interactions in vitro, but recent research advances make it possible to manipulate the gamete in vitro. Here, we
Akiko Hirao et al.
PloS one, 4(9), e6909-e6909 (2009-09-10)
The peripheral circadian clock in mice is entrained not only by light-dark cycles but also by daily restricted feeding schedules. Behavioral and cell culture experiments suggest an increase in glucose level as a factor in such feeding-induced entrainment. For application
Nadja Osterberg et al.
Cell and tissue research, 336(1), 11-20 (2009-02-19)
Serotonergic (5-HT) neurons of the reticular formation play a key role in the modulation of behavior, and their dysfunction is associated with severe neurological and psychiatric disorders, such as depression and schizophrenia. However, the molecular mechanisms underlying the differentiation of
Raju V S Rajala et al.
Journal of neurochemistry, 110(5), 1648-1660 (2009-07-07)
The insulin receptor (IR) and IR signaling proteins are widely distributed throughout the CNS. IR signaling provides a trophic signal for transformed retinal neurons in culture and we recently reported that deletion of IR in rod photoreceptors by Cre/lox system
Györgyi Műzes et al.
Comparative immunology, microbiology and infectious diseases, 52, 48-57 (2017-07-05)
The influence of cell-free DNA (fDNA) administration on the TLR9-autophagy regulatory crosstalk within inflammatory circumstances remains unclear. To examine the immunobiologic effects of iv. fDNA injection on the TLR9-mediated autophagy response in murine DSS-colitis. Different types of modified fDNAs were
Mohammed A Khan et al.
Infection and immunity, 76(4), 1410-1422 (2008-01-30)
Enteropathogenic Escherichia coli (EPEC) and the murine pathogen Citrobacter rodentium belong to the attaching and effacing (A/E) family of bacterial pathogens. These noninvasive bacteria infect intestinal enterocytes using a type 3 secretion system (T3SS), leading to diarrheal disease and intestinal
Hideaki Oike et al.
PloS one, 6(8), e23709-e23709 (2011-09-09)
The circadian clock is closely associated with energy metabolism. The liver clock can rapidly adapt to a new feeding cycle within a few days, whereas the lung clock is gradually entrained over one week. However, the mechanism underlying tissue-specific clock
Hae-Ran Park et al.
BMC cancer, 9, 85-85 (2009-03-19)
Although cisplatin is one of the most effective chemotherapeutic agents, cisplatin alone does not achieve a satisfactory therapeutic outcome. Also cisplatin accumulation shows toxicity to normal tissues. In this study, we examined the possibility of HemoHIM both to enhance anticancer
Zheng-Shun Wen et al.
Marine drugs, 9(6), 1038-1055 (2011-07-13)
The study was conducted to investigate the promoted immune response to ovalbumin in mice by chitosan nanoparticles (CNP) and its toxicity. CNP did not cause any mortality or side effects when mice were administered subcutaneously twice with a dose of
Ferenc Sipos et al.
Pathology oncology research : POR, 20(4), 867-877 (2014-04-12)
In inflammatory bowel diseases the presence of free-circulating DNA (fcDNA) sequences in the sera is an established phenomenon, albeit its real biological function still remains unclear. In our study the immunobiologic effects of a single-dose, intravenously administered fcDNA of normal
Jamie L Fornek et al.
Journal of virology, 83(21), 11102-11115 (2009-08-21)
The transmission of H5N1 influenza viruses from birds to humans poses a significant public health threat. A substitution of glutamic acid for lysine at position 627 of the PB2 protein of H5N1 viruses has been identified as a virulence determinant.
Athina-Myrto Chioni et al.
Methods in molecular biology (Clifton, N.J.), 1487, 255-267 (2016-12-08)
Organotypic models are 3D in vitro representations of an in vivo environment. Their complexity can range from an epidermal replica to the establishment of a cancer microenvironment. These models have been used for many years, in an attempt to mimic
Wilson Roberto Poi et al.
Brazilian dental journal, 24(5), 437-445 (2014-01-30)
Dental avulsion is the most severe type of traumatic tooth injuries because it causes damage to several structures and results in the complete displacement of the tooth from its socket in the alveolar bone. The ideal situation is to replant
Aleksandra S Chikina et al.
Cell, 183(2), 411-428 (2020-09-25)
The colon is primarily responsible for absorbing fluids. It contains a large number of microorganisms including fungi, which are enriched in its distal segment. The colonic mucosa must therefore tightly regulate fluid influx to control absorption of fungal metabolites, which
Xiu-Li Kuang et al.
BMC neuroscience, 11, 137-137 (2010-10-26)
Neuron-derived neurotrophic factor (NDNF) is evolutionarily well conserved, being present in invertebrate animals such as the nematode, Caenorhabditis elegans, as well as in the fruit fly, Drosophila melanogaster. Multiple cysteines are conserved between species and secondary structure prediction shows that
Sarah E W Grubb et al.
Infection and immunity, 77(9), 3872-3878 (2009-07-08)
Candida albicans is a commensal organism that under certain circumstances can become pathogenic. During systemic infection C. albicans is disseminated via the circulation to distant organs, where it causes multiple organ failure. Despite the severity of systemic C. albicans infection
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