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Tanja Zeller et al.
European journal of epidemiology, 29(10), 777-790 (2014-09-23)
Biomarkers are considered as tools to enhance cardiovascular risk estimation. However, the value of biomarkers on risk estimation beyond European risk scores, their comparative impact among different European regions and their role towards personalised medicine remains uncertain. Biomarker for Cardiovascular
Elisa Evangelisti et al.
Journal of Alzheimer's disease : JAD, 41(1), 289-300 (2014-03-13)
Increasing evidence indicates that interaction of amyloid-β peptide (Aβ) with the cell membrane is a primary step in Alzheimer's disease (AD) neurotoxicity. In particular, it has been demonstrated that lipid rafts are key sites of Aβ production, aggregation, and interaction
Yun Hu et al.
PloS one, 10(4), e0122643-e0122643 (2015-04-11)
Betaine is reported to regulate hepatic cholesterol metabolism in mammals. Chicken eggs contain considerable amount of betaine, yet it remains unknown whether and how betaine in the egg affects hepatic cholesterol metabolism in chicks. In this study, eggs were injected
Tamsyn M Uren Webster et al.
Environmental science & technology, 49(5), 3110-3118 (2015-01-31)
The herbicide linuron is used worldwide, and has been detected in surface waters as well as in food and drinking water. Toxicological studies have reported that linuron acts as an antiandrogen in vitro and in vivo and disrupts mammalian male
Wei-Te Wu et al.
PloS one, 10(6), e0130279-e0130279 (2015-06-27)
The purpose of this study was to investigate the association between apnea-hypopnea index (AHI) and metabolic markers and whether the elevated risk of Metabolic Syndrome (MetS) is related to Obstructive Sleep Apnea (OSA). This cross-sectional study recruited 246 male bus
Suvi-Katriina Ruokonen et al.
Journal of chromatography. A, 1405, 178-187 (2015-06-15)
The effect of three phosphonium and imidazolium ionic liquids (ILs) on the interaction between liposomes and common pharmaceuticals found in wastewaters was studied. The liposomes comprised zwitterionic phosphatidyl choline and negatively charged phosphatidyl glycerol. A set of common cationic, anionic
Myoung Jin Son et al.
Cytotechnology, 67(4), 641-652 (2014-05-06)
There have been studies on health beneficial effects of ginger and its components. However, there still remain certain aspects that are not well defined in their anti-hyperglycemic effects. Our aims were to find evidence of possible mechanisms for antidiabetic action
Yanyan Zhao et al.
Toxicology, 328, 135-141 (2014-12-17)
There is growing evidence that microcystins (MCs) act as hazardous materials and can disrupt the endocrine systems of animals. However, the response of thyroid function and the related energy metabolism following MCs exposure is still unknown. In the present study
Roopali Saxena et al.
Biochimica et biophysica acta, 1848(8), 1699-1705 (2015-05-13)
The function of membrane receptors in the nervous system depends on physicochemical characteristics of neuronal membranes such as membrane order and phase. In this work, we have monitored the changes in hippocampal membrane order and related parameters by cholesterol and
Farah Djelti et al.
Journal of diabetes, 7(4), 512-522 (2014-08-30)
The aim of this investigation was to determine the in vitro effects of linseed, olive and Nigel oils on T cell proliferation and function in gestational diabetes. Blood samples were collected from 40 control healthy and 32 gestational diabetic mothers
Hidetaka Akita et al.
Journal of controlled release : official journal of the Controlled Release Society, 200, 97-105 (2014-12-30)
A renal cell carcinoma (RCC) is one of the refractory tumors, since it readily acquires resistance against chemotherapy. Thus, alternative therapeutic approaches such as obstructing the neovasculature are needed. We previously reported on the development of a plasmid DNA (pDNA)-encapsulating
Abdulkadir Yildiz et al.
Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 21(3), 223-228 (2014-01-17)
The aim of the study was to evaluate the utility of the preprocedural platelet-lymphocyte ratio (PLR) for predicting no reflow in patients undergoing primary percutaneous intervention (PCI) for the treatment of ST-segment elevation myocardial infarction. The thrombolysis in myocardial infarction
Fang Wang et al.
Lipids in health and disease, 14, 49-49 (2015-05-23)
The fruiting body of Ganoderma lucidum has been used as a traditional herbal medicine for many years. However, to the date, there is no detailed study for describing the effect of G. lucidum spores on oxidative stress, blood glucose level
Mark Mahadeo et al.
Biochimica et biophysica acta, 1848(5), 1165-1174 (2015-02-18)
Membrane organization has received substantial research interest since the degree of ordering in membrane regions is relevant in many biological processes. Here we relate the impact of varying cholesterol concentrations on native secretory vesicle fusion and the lateral domain organization
Giovanni Grandi et al.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 31(10), 774-778 (2015-08-21)
To study the three cycles effect on primary dysmenorrhea of the monophasic 24/4 estradiol/nomegestrol acetate (E2/NOMAC) and of the 21/7 ethinyl-estradiol/chlormadinone acetate (EE/CMA) oral contraceptive. The tolerability and the effect of both preparations on metabolism and health-related quality of life
Astrid Drivsholm Sloth et al.
BMJ open, 5(4), e006923-e006923 (2015-04-04)
Remote ischaemic conditioning (RIC) promotes cardioprotection in patients undergoing primary percutaneous coronary intervention (pPCI) for ST-elevation myocardial infarction (STEMI). The effect of RIC may be modified by cardiovascular risk factors and their medications. We examined whether cardiovascular risk factors, lipid
Parco M Siu et al.
Diabetology & metabolic syndrome, 7, 40-40 (2015-05-23)
Metabolic syndrome (MetS) is a clustering of cardiovascular risk factors, which is associated with diabetes mellitus and cardiovascular disease. Lifestyle interventions applied to people with MetS has considerable beneficial effects on disease preventive outcomes. This study aimed to examine the
Ji Miao et al.
Nature communications, 6, 6498-6498 (2015-04-08)
Despite the well-documented association between insulin resistance and cardiovascular disease, the key targets of insulin relevant to the development of cardiovascular disease are not known. Here, using non-biased profiling methods, we identify the enzyme flavin-containing monooxygenase 3 (Fmo3) to be
Moshe Ben-David et al.
Journal of molecular biology, 427(6 Pt B), 1359-1374 (2015-02-04)
Despite the abundance of membrane-associated enzymes, the mechanism by which membrane binding stabilizes these enzymes and stimulates their catalysis remains largely unknown. Serum paraoxonase-1 (PON1) is a lipophilic lactonase whose stability and enzymatic activity are dramatically stimulated when associated with
Rumyana Dimova et al.
Diabetes research and clinical practice, 109(2), 262-270 (2015-06-04)
The aim of the study was to evaluate cardiovascular autonomic function (CAF) at different stages of obesity and in the presence of metabolic syndrome (MetS), and its association with metabolic parameters and hsCRP in subjects with normal glucose tolerance (NGT)
Walid Hamdy El-Tantawy et al.
Zeitschrift fur Naturforschung. C, Journal of biosciences, 70(5-6), 139-144 (2015-06-23)
The hypolipidemic effect of an ethanolic extract from the roots and rhizomes of Panicum repens L. was investigated in rats suffering from high-cholesterol, diet-induced hyperlipidemia, and the phytochemicals in the extract were analyzed. The extract was administered p.o. in doses
Sophie Liabeuf et al.
PloS one, 10(7), e0131707-e0131707 (2015-07-17)
Although a variety of non-invasive methods for measuring cardiovascular (CV) risk (such as carotid intima media thickness, pulse wave velocity (PWV), coronary artery and aortic calcification scores (measured either by CT scan or X-ray) and the ankle brachial index (ABI))
Michael F La Fountaine et al.
Lipids in health and disease, 14, 81-81 (2015-07-29)
Persons with spinal cord injury (SCI) often have low levels of physical activity, which predispose to increased adiposity and decreased high density lipoprotein cholesterol (HDL-C) concentrations, and, generally, normal low density lipoprotein cholesterol (LDL-C) concentrations. In spite of the mixed
Sriram Devanathan et al.
PloS one, 9(7), e101900-e101900 (2014-07-08)
Estrogen exerts diverse biological effects in multiple tissues in both animals and humans. Much of the accumulated knowledge on the role of estrogen receptor (ER) in the heart has been obtained from studies using ovariectomized mice, whole body ER gene
Mikito Nishikawa et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 30(6), 934-942 (2015-04-17)
Exercise capacity and quality of life are markedly impaired in chronic kidney disease (CKD). Increased plasma uremic toxins such as indoxyl sulfate (IS), which induce oxidative stress, may be involved in this process. An oral adsorbent, AST-120, can reduce circulating
Gregor Lorbek et al.
Scientific reports, 5, 8777-8777 (2015-03-06)
We demonstrate unequivocally that defective cholesterol synthesis is an independent determinant of liver inflammation and fibrosis. We prepared a mouse hepatocyte-specific knockout (LKO) of lanosterol 14α-demethylase (CYP51) from the part of cholesterol synthesis that is already committed to cholesterol. LKO
Tiziana Montalcini et al.
Nutrients, 7(7), 5933-5947 (2015-07-21)
It has been demonstrated that a vegetarian diet may be effective in reducing body weight, however, the underlying mechanisms are not entirely clear. We investigated whether there is a difference in resting energy expenditure between 26 vegetarians and 26 non-vegetarians
Oscar Haigh et al.
Journal of controlled release : official journal of the Controlled Release Society, 194, 148-156 (2014-09-07)
The barrier morphology of skin provides major obstacles for the application of siRNA for gene silencing, which current delivery technologies do not effectively overcome. Emerging technologies utilise microprojection array devices to penetrate into the skin epidermis and dermis for delivery
Yuki Shuto et al.
PloS one, 10(8), e0136840-e0136840 (2015-08-28)
A number of epidemiological studies demonstrated that postprandial hyperglycemia is a risk factor for cardiovascular disease in individuals with impaired glucose tolerance. Although several laboratory studies have addressed the plausible causal role of postprandial acute hyperglycemia (glucose spikes) in the
Shuangxia Ren et al.
The Journal of pharmacy and pharmacology, 66(9), 1231-1239 (2014-04-11)
The clinical application of doxorubicin (DOX) is limited by severe systemic side effects. The aim of this study was to develop a strategy that combined the liposomal DOX (LipDOX) and intratumoral injection to reduce the toxicity and enhance the antitumor
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